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The International Journal of... 2018The goal of this investigation was to evaluate the bone-to-implant contact (BIC) of dental implants placed into fresh extraction sockets without pre-existing periapical...
The goal of this investigation was to evaluate the bone-to-implant contact (BIC) of dental implants placed into fresh extraction sockets without pre-existing periapical pathology. When the extraction sites exhibited a gap distance of > 2 mm, autogenous bone harvested from surrounding surgical sites was grafted to fill that gap with no barrier membranes. All implants were clinically stable and successful at 6 months postoperative. The histologic examination demonstrated an average of 66.2% BIC for all five immediately placed dental implants. The results of this study provided sufficient histologic and histomorphometric knowledge to support immediate dental implant placement in carefully selected clinical scenarios.
Topics: Dental Implants; Dental Prosthesis Design; Humans; Immediate Dental Implant Loading; Osseointegration; Radiography, Dental; Titanium; Tooth Socket
PubMed: 29447307
DOI: 10.11607/prd.3558 -
Scientific Reports Mar 2019Dental implantation has been the primary method for the treatment of tooth loss, but longer than 3 months healing times are generally required. Because immediate load...
Dental implantation has been the primary method for the treatment of tooth loss, but longer than 3 months healing times are generally required. Because immediate load implants are suitable only for certain categories of implant patients, it has value to develop a novel method to facilitate the implant-bone osseointegration process. Cylindrical titanium implants were implanted in the tooth sockets of beagles, and microelectrode stimulation of the sympathetic nerves in the infraorbital nerve was performed after implantation for 1 week. The authors found that one-sided nerve stimulation was shown to evoke consistent electric potential changes in both sides of the infraorbital nerves. Moreover, after 4 weeks of implantation, more new bone was clearly observed around the implants in the beagles that received electrical stimulation treatment than was observed in the control animals. Furthermore, a higher mineralization density was measured in the new peri-implant bone tissues of the stimulated beagles when compared to controls. These results demonstrate that the simple and safe physical method of microelectrode stimulation to sympathetic nerves can promote the formation of new bone and the osseointegration of implants. This technique is worth promoting and has the potential to reduce the healing time of dental implantation in future clinical cases.
Topics: Animals; Bone Density; Calcification, Physiologic; Dental Implants; Dogs; Electric Stimulation; Female; Humans; Incisor; Maxilla; Maxillary Nerve; Microelectrodes; Osseointegration; Osteogenesis; Surface Properties; Titanium; Tooth Extraction; Tooth Socket; Wound Healing
PubMed: 30894667
DOI: 10.1038/s41598-019-41471-z -
Mund-, Kiefer- Und Gesichtschirurgie :... Jan 2003SUBJECT MATTER: In cases of bilateral cleft lip, alveolus and palate, preoperative positioning of the premaxilla using Latham's appliance has been described. This method...
UNLABELLED
SUBJECT MATTER: In cases of bilateral cleft lip, alveolus and palate, preoperative positioning of the premaxilla using Latham's appliance has been described. This method is controversial, since it may cause growth defects.
PATIENTS AND METHODS
From 1992 to 2000, Latham's appliance was inserted preoperatively into 20 patients with bilateral lip, alveolus and palate clefts with extreme premaxillary protrusion. Pin fixation ensued at the age of 3 months. After adjustment of the premaxilla, the soft palate was closed and bilateral lip adhesion as well as bilateral gingivoperiosteoplasty were performed directly after the removal of the appliance. Final lip closure took place 4-6 weeks later. At the age of 2 years, the hard palate was closed. Evaluation was based on combined face-maxilla models, standard photographs and, when available, lateral skull x-rays showing the relative position of the segments, the influence of Latham's appliance on the nasal septum and the relation of the upper jaw to the skull base and mandibula.
RESULTS
In all cases, a satisfactory alveolar alignment was achieved; thickening and curvature of the nasal septum occurred but receded. Neither growth disturbances nor dental germ damage were seen. In two cases, complications arose from suture dehiscence of the lip adhesion: in one patient, a screw defect caused a loosening of the appliance and there was also a transmigration of the postpremaxillary pin.
CONCLUSIONS
On the basis of our experience, the use of Latham's appliance, combined with consistent orthodontic supervision and, if necessary, treatment, represents a practical option for the treatment of bilateral cleft lip, alveolus and palate, especially in cases with extreme protrusion of the premaxilla.
Topics: Alveoloplasty; Bone Nails; Cephalometry; Cleft Lip; Cleft Palate; Female; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Infant; Infant, Newborn; Male; Palatal Obturators; Preoperative Care; Radiography; Reoperation; Tooth Socket
PubMed: 12556982
DOI: 10.1007/s10006-002-0438-8 -
Zhonghua Kou Qiang Yi Xue Za Zhi =... Apr 2013
Topics: Dental Implantation, Endosseous; Humans; Tooth Socket
PubMed: 24021194
DOI: No ID Found -
Acta Odontologica Latinoamericana : AOL 2010In recent years there has been increasing interest in the choice of the best material for bone substitutes. Experimental models enable estimation of biological...
In recent years there has been increasing interest in the choice of the best material for bone substitutes. Experimental models enable estimation of biological potential, efficacy and safety of a biomaterial before its clinical application. The aim of this study was to evaluate the response of a bone substitute, UNC bone matrix powder (MOeP-UNC), for repairing the post-extraction alveolus in Wistar rats. Rats' first lower molars were extracted. The right alveoli were filled with MOeP-UNC hydrated with physiological saline (Experimental Group, EG), and the left alveoli were used as Control Group (CG). Thirty days after extraction, the animals were killed and the samples processed. Histological sections were made in vestibular-lingual direction at the level of the mesial alveolus of the first inferior molar (Guglielmotti et al. J. Oral Maxillofac. Surg. 1985;43(5):359-364). Repair of the alveoli at 30 days after extraction was evaluated histologically. Repair of the alveolus was optimum in the control group at 30 days, and the EG showed presence of MOeP-UNC particles in close contact with newly formed bone tissue (osseointegration). In the experimental model used, at 30 days post-surgery, the MOeP-UNC particles integrate compatibly with newly formed bone tissue.
Topics: Animals; Bone Substitutes; Male; Rats; Rats, Wistar; Tooth Extraction; Tooth Socket
PubMed: 20645642
DOI: No ID Found -
Bone Sep 2018
Topics: Animals; Male; Obesity; Osteogenesis; Random Allocation; Rats; Rats, Wistar; Tooth Extraction; Tooth Socket; Weight Gain; Wound Healing
PubMed: 29935255
DOI: 10.1016/j.bone.2018.06.017 -
Journal of Cranio-maxillo-facial... May 2017Aging brings a number of health conditions that can compromise the healing process in elderly individuals, significantly when it comes to bone tissue. The aim of the...
INTRODUCTION
Aging brings a number of health conditions that can compromise the healing process in elderly individuals, significantly when it comes to bone tissue. The aim of the present study was to analyze the effects of zoledronic acid (ZL) therapy on socket healing of aged male rats.
MATERIALS AND METHODS
Twenty-four Wistar male rats, 20 months old, underwent surgical procedures for the extraction of the upper right incisor and were divided into two groups according to the treatment: Control (C) - intravenous (IV) 0.9% saline, ZL - 0.035 mg/kg of IV zoledronic acid, both every 15 days. At the fifth dose of both substances, tooth extractions were performed and the animals were euthanized after 14 and 28 days.
RESULTS
IV administration of ZL caused OPG-RANKL system imbalance, resulting in deficient bone formation and remodeling and alteration of osteoclast morphology, as well as maintaining persistent inflammation during the healing period.
CONCLUSIONS
IV administration of ZL delayed extracted dental socket healing of aged rats, but not enough to cause osteonecrosis, raising a question about different responses to IV BP therapy considering animal age.
Topics: Age Factors; Animals; Bone Density Conservation Agents; Diphosphonates; Imidazoles; Male; Osteogenesis; Rats; Rats, Wistar; Tooth Extraction; Tooth Socket; Zoledronic Acid
PubMed: 28318924
DOI: 10.1016/j.jcms.2017.02.002 -
Compendium of Continuing Education in... Jul 2017Immediate implant placement can pose challenges surgically and, ultimately, restoratively. Yet immediate placement has become the standard when adequate bone is present...
Immediate implant placement can pose challenges surgically and, ultimately, restoratively. Yet immediate placement has become the standard when adequate bone is present to achieve primary stability and site infection is minimal. To avoid prosthetic complications and ensure the implant is encased in bone after healing, proper planning must consider that implant placement does not necessarily need to follow the trajectory of the root socket. As discussed in this article, maxillary anterior sites have potential issues related to the "triangle of bone" that are not encountered in molar sites and demand different approaches to ensure treatment success. Additionally, this article addresses decision-making on molar sites in regard to implant diameter, as well as the rationale for platform switching.
Topics: Dental Implants; Dental Prosthesis Design; Humans; Immediate Dental Implant Loading; Radiography, Dental; Tooth Socket
PubMed: 28727471
DOI: No ID Found -
Oral and Maxillofacial Surgery Sep 2021To histologically analyze the effect of a curettage of the granulation tissue on healing at implants installed immediately after the extraction of teeth presenting...
OBJECTIVE
To histologically analyze the effect of a curettage of the granulation tissue on healing at implants installed immediately after the extraction of teeth presenting periapical lesions.
MATERIAL AND METHODS
In seven dogs, the dental pulp was removed from the pulp chamber and from the root canals of the right and left third and the fourth mandibular premolars and of the left second premolar. The chambers were left opened and, after 3 months, apical lesions were present, and the premolars were extracted. One alveolus each premolar was selected and, before implant installation, the apical lesions of two alveoli were curetted (curettage group) while the other three were not treated (no-treatment group). The second right premolar was also extracted (Negative control group). Six implants each dog were installed, and a fully submerged healing was allowed. Four months after, biopsies were collected, and histological analyses were performed.
RESULTS
The proportions of new bone at the entire body of the implant was 70.2 ± 10.7% at the no-treatment group, 72.1 ± 14.8% at the curettage group, and 69.6 ± 3.7% at the negative control group. The respective new bone proportion at the apical aspect of the implants was 68.4 ± 17.5%, 61.5 ± 27.3%, and 78.1 ± 5.7%. None of the differences among the various groups were statistically significant. No inflammatory infiltrates were seen in the apical region.
CONCLUSIONS
In this experimental study, it is concluded that the removal of the granulation tissue seems not to be necessary to obtain a proper osseointegration of implants installed immediately after the extraction of teeth presenting a periapical lesion.
Topics: Animals; Bicuspid; Dental Implantation, Endosseous; Dental Implants; Dogs; Osseointegration; Tooth Socket; Wound Healing
PubMed: 33219872
DOI: 10.1007/s10006-020-00926-8 -
International Immunopharmacology Jul 2021Malnutrition causes prolonged inflammation, resulting in delayed wound healing. High mobility group box-1 (HMGB1) is a damage-associated molecular pattern that is...
Malnutrition causes prolonged inflammation, resulting in delayed wound healing. High mobility group box-1 (HMGB1) is a damage-associated molecular pattern that is present in the nuclei of macrophages and is secreted into the extracellular milieu in response to stimuli. It stimulates the production of interleukin-1β (IL-1β) through the receptors for advanced glycation end products (RAGE), inducing an inflammatory response, which is an essential response to initiate wound healing. We hypothesized that malnutrition may interfere with this cascade, causing abnormal inflammation and ultimately delaying wound healing. We used tooth-extracted mice with malnutrition fed with low-casein diet for two weeks. On days 3 and 7 after tooth extraction, the wound tissue was histologically observed and analyzed for several factors in the inflammation-regeneration lineage, including IL-1β, mesenchymal stem cells, myeloperoxidase activity, HMGB1, macrophage polarization, and adenosine 5-triphosphate (ATP). On day 7, delayed wound healing was observed with the following findings under malnutrition conditions: decreased mRNA expression of genes for regeneration and mesenchymal stem cell (MSC) accumulation, an obvious increase in myeloperoxidase and IL-1β mRNA expression, an increase in HMGB1 levels, and an increase in ATP concentration in tissues with elevated proportion of M2 macrophages. These results suggest that the significantly increased secretion of HMGB1 associated with the upregulated production of ATP and IL-1β secretion via the RAGE pathway may interfere with the resolution of inflammation and wound healing under the state of malnutrition.
Topics: Adenosine Triphosphate; Animals; Cytokines; Disease Models, Animal; Gingiva; HMGB1 Protein; Inflammation; Macrophage Activation; Male; Malnutrition; Mesenchymal Stem Cells; Mice, Inbred C57BL; Receptor for Advanced Glycation End Products; Regeneration; Time Factors; Tooth Extraction; Tooth Socket; Wound Healing; Mice
PubMed: 34162142
DOI: 10.1016/j.intimp.2021.107772