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Lakartidningen Aug 2020
Topics: Amdinocillin Pivoxil; Humans; Pyelonephritis
PubMed: 32852775
DOI: No ID Found -
Praxis Sep 2018
Comparative Study Randomized Controlled Trial
Topics: Acute Disease; Adolescent; Adult; Amdinocillin Pivoxil; Double-Blind Method; Escherichia coli Infections; Female; Humans; Ibuprofen; Middle Aged; Staphylococcal Infections; Staphylococcus saprophyticus; Urinary Tract Infections; Young Adult
PubMed: 30227793
DOI: 10.1024/1661-8157/a003067 -
Antimicrobial Agents and Chemotherapy Apr 1988The bioavailability of amdinocillin was not altered when amdinocillin pivoxil was ingested 1 h before a standard breakfast, and it increased by 20% when amdinocillin...
The bioavailability of amdinocillin was not altered when amdinocillin pivoxil was ingested 1 h before a standard breakfast, and it increased by 20% when amdinocillin pivoxil was ingested with or 1 h after a standard breakfast. Amdinocillin pivoxil would be convenient for patients since it may be taken with or without food.
Topics: Administration, Oral; Adult; Amdinocillin; Amdinocillin Pivoxil; Biological Availability; Chromatography, High Pressure Liquid; Female; Food; Humans; Male; Middle Aged; Random Allocation
PubMed: 3377469
DOI: 10.1128/AAC.32.4.592 -
Archives de Pediatrie : Organe Officiel... May 2002Antibiotics are usually used to prevent childhood recurrent urinary tract infections: cystitis or pyelonephritis. The mechanism of action of these antibiotics, although... (Review)
Review
Antibiotics are usually used to prevent childhood recurrent urinary tract infections: cystitis or pyelonephritis. The mechanism of action of these antibiotics, although imperfectly known, seems to be double: the antibiotic acts by its bactericidal effect, but also probably for minimal concentrations by reducing adhesion capability of bacteria to the urothelium. The most commonly used molecules are cotrimoxazole, trimethoprime, pivmecillinam, cefaclor and nalidixic acid. However all have not been studied rigorously as for their prophylactic capacity, and in particular very little is known for patients presenting with vesico-ureteral reflux.
Topics: Amdinocillin Pivoxil; Anti-Infective Agents, Urinary; Antibiotic Prophylaxis; Cefaclor; Child; Cystitis; Humans; Pyelonephritis; Trimethoprim, Sulfamethoxazole Drug Combination
PubMed: 12053547
DOI: 10.1016/s0929-693x(01)00835-1 -
Drug and Therapeutics Bulletin Dec 1978
Topics: Amdinocillin; Amdinocillin Pivoxil; Enterobacteriaceae Infections; Humans; Penicillanic Acid; Urinary Tract Infections
PubMed: 214285
DOI: No ID Found -
British Journal of Clinical Pharmacology Jun 19771 The plasma concentration/time curves of ampicillin and mecillinam in normal subjects were measured after oral administration of ampicillin (500 mg) and pivmecillinam...
1 The plasma concentration/time curves of ampicillin and mecillinam in normal subjects were measured after oral administration of ampicillin (500 mg) and pivmecillinam (400 and 600 mg). 2 Similar plasma concentration/time curves of ampicillin and mecillinam in the starved normal subjects followed oral administration of ampicillin (500 mg) and pivmecillinam (600 mg). 3 The plasma concentration/time curve of mecillinam was measured in the same normal subjects after oral administration of pivmecillinam (400 mg) with a reproducible standardized Lundh test meal. 4 There was no statistically significant difference in the plasma concentration/time curve of mecillinam after pivmecillinam/400 mg) and the meal compared with the plasma concentration/time curve after oral pivmecillinam (400 mg) was given to the same subjects when starved. After administration of pivmecillinam (400 mg) with meal, Tasc was significantly delayed beyond the value obtained when the subjects were starved. 5 The pharmacokinetics of pivmecillinam in coeliac disease are normal. This finding contrasts with previous studies on the pharmacokinetics of another pivaloyloxymethylpenicillin ester, pivampicillin, in this condition.
Topics: Adolescent; Adult; Amdinocillin Pivoxil; Ampicillin; Biological Assay; Celiac Disease; Escherichia coli; Food; Humans; Intestinal Absorption; Kinetics; Middle Aged; Penicillanic Acid; Sarcina; Starvation
PubMed: 197981
DOI: 10.1111/j.1365-2125.1977.tb00711.x -
International Journal of Epidemiology Apr 2010Ciprofloxacin, ceftriaxone and pivmecillinam are the antibiotics currently recommended by the World Health Organization (WHO) for the treatment of dysentery in children;... (Meta-Analysis)
Meta-Analysis Review
BACKGROUND
Ciprofloxacin, ceftriaxone and pivmecillinam are the antibiotics currently recommended by the World Health Organization (WHO) for the treatment of dysentery in children; yet there have been no reviews of the clinical effectiveness of these antibiotics in recent years.
METHODS
We reviewed all literature reporting the effect of ciprofloxacin, ceftriaxone and pivmecillinam for the treatment of dysentery in children in the developing countries. We used a standardized abstraction and grading format and performed meta-analyses to determine the effect of treatment with these antibiotics on rates of treatment failure, bacteriological failure and bacteriological relapse. The CHERG Standard Rules were applied to determine the final effect of treatment with these antibiotics on diarrhoea mortality.
RESULTS
Eight papers were selected for abstraction. Treatment with ciprofloxacin, ceftriaxone or pivmecillinam resulted in a cure rate of >99% while assessing clinical failure, bacteriological failure and bacteriological relapse.
CONCLUSIONS
The antibiotics recommended by the WHO--ciprofloxacin, ceftriaxone and pivmecillinam--are effective in reducing the clinical and bacteriological signs and symptoms of dysentery and thus can be expected to decrease diarrhoea mortality attributable to dysentery.
Topics: Amdinocillin Pivoxil; Anti-Bacterial Agents; Ceftriaxone; Child, Preschool; Ciprofloxacin; Dysentery; Dysentery, Bacillary; Female; Humans; Infant; Male; Randomized Controlled Trials as Topic; Salmonella Infections; Shigella dysenteriae; Treatment Outcome
PubMed: 20348130
DOI: 10.1093/ije/dyq024 -
Euro Surveillance : Bulletin Europeen... May 2023IntroductionEmpirical therapy for the treatment of urinary tract infections should be tailored to the current distribution and susceptibility of potential pathogens to...
IntroductionEmpirical therapy for the treatment of urinary tract infections should be tailored to the current distribution and susceptibility of potential pathogens to ensure optimal treatment.AimWe aimed to provide an up-to-date overview of the epidemiology and susceptibility of Enterobacterales isolated from urine in Germany.MethodsWe retrospectively analysed antimicrobial susceptibility data from 201,152 urine specimens collected between January 2016 and June 2021 from in- and outpatients. Multiple logistic regression analysis was used to evaluate the association between year of investigation and antibiotic resistance, adjusted for age, sex and species subgroup. Subgroup analyses were performed for midstream urine samples obtained from (i) female outpatients aged 15 to 50 years, (ii) female outpatients older than 50 years and (iii) male outpatients.ResultsResistance rates of less than 20% were observed for nitroxoline (3.9%), fosfomycin (4.6%), nitrofurantoin (11.7%), cefuroxime (13.5%) and ciprofloxacin (14.2%). Resistance to trimethoprim/sulfamethoxazole (SXT) (20.1%), amoxicillin-clavulanic acid (20.5%), trimethoprim (24.2%), pivmecillinam (29.9%) and ampicillin (53.7%) was considerably higher. In the subgroup of outpatient women aged 15-50 years, resistance rates were generally lower. Resistance rates of all antibiotics decreased from 2016 to 2021. Multiple logistic regression revealed the lowest adjusted odds ratio (ORadj) of 0.838 (95% confidence interval (CI): 0.819-0.858; p < 0.001) for pivmecillinam and the highest ORadj of 0.989 (95% CI: 0.972-1.007; p = 0.226) for nitrofurantoin.ConclusionsResistance has generally decreased over the past years, independent of sex, age and causative pathogen. Our data provide an important basis for empirical antibiotic recommendations in various settings and patient collectives.
Topics: Female; Male; Humans; Anti-Bacterial Agents; Nitrofurantoin; Amdinocillin Pivoxil; Retrospective Studies; Escherichia coli; Drug Resistance, Bacterial; Urinary Tract Infections; Trimethoprim, Sulfamethoxazole Drug Combination; Germany; Microbial Sensitivity Tests; Escherichia coli Infections
PubMed: 37166759
DOI: 10.2807/1560-7917.ES.2023.28.19.2200568 -
The Journal of Antimicrobial... Feb 1981
Clinical Trial Randomized Controlled Trial
Topics: Amdinocillin Pivoxil; Bacteriuria; Drug Combinations; Humans; Male; Penicillanic Acid; Prostatectomy; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination
PubMed: 6260729
DOI: 10.1093/jac/7.2.209