-
A.M.A. Archives of Dermatology Aug 1955
Topics: Aminopterin; Humans; Psoriasis
PubMed: 14397845
DOI: 10.1001/archderm.1955.03730320035005 -
Ryoikibetsu Shokogun Shirizu 2001
Review
Topics: Aminopterin; Antimetabolites, Antineoplastic; Female; Fetal Diseases; Humans; Infant, Newborn; Methotrexate; Pregnancy
PubMed: 11462628
DOI: No ID Found -
Nordisk Medicin Feb 1955
Topics: Aminopterin
PubMed: 14356467
DOI: No ID Found -
Journal of Immunological Methods Jul 1987Aminopterin is used in cell fusion experiments to select for hybrid cells by killing unfused cells which are deficient in enzymes for nucleotide salvage pathways....
Aminopterin is used in cell fusion experiments to select for hybrid cells by killing unfused cells which are deficient in enzymes for nucleotide salvage pathways. Aqueous aminopterin solutions exposed to fluorescent room light (wavelength greater than 300 nm) were found to lose cytotoxicity. Inactivation was accompanied by changes in the ultraviolet absorption spectra of the solutions. The ultraviolet spectrum of an irradiated aminopterin solution is used to provide a quantitative measure of its cytotoxicity. Aminopterin appears to be photolytically cleaved at the C9-N10 methylene-anilino bond in a reaction analogous to that known for the photolysis of folic acid irradiated at 365 nm (Lowry et al., 1949).
Topics: Aminopterin; Chromatography, High Pressure Liquid; Fluorescence; Hybridomas; Hydrogen-Ion Concentration; Light; Photolysis
PubMed: 3611791
DOI: 10.1016/0022-1759(87)90227-4 -
Dermatologic Clinics Oct 2015This article reviews methotrexate and the more potent, related compound, pralatrexate, for the treatment of cutaneous T-cell lymphomas, including mycosis fungoides,... (Review)
Review
This article reviews methotrexate and the more potent, related compound, pralatrexate, for the treatment of cutaneous T-cell lymphomas, including mycosis fungoides, SĂ©zary syndrome, and CD30+Â lymphoproliferative disorders. Although these folate antagonists are traditionally viewed as antiproliferative cell cycle inhibitors, it is recognized that they inhibit DNA methylation, providing a rationale for their use as epigenetic regulators and cell proliferation inhibitors. The underlying mechanisms are outlined, key supporting data presented, followed by brief mention of recent mathematical modeling supporting the general superiority of combination therapy. Several novel examples involving folate antagonists are proposed.
Topics: Aminopterin; Antimetabolites, Antineoplastic; Apoptosis; DNA Methylation; Epigenesis, Genetic; Folic Acid Antagonists; Humans; Lymphoma, T-Cell, Cutaneous; Methotrexate; S Phase; Skin Neoplasms
PubMed: 26433846
DOI: 10.1016/j.det.2015.05.009 -
The Journal of Investigative Dermatology Jan 1959
Topics: Aminopterin; Humans; Psoriasis
PubMed: 13620968
DOI: No ID Found -
Progress in Medicinal Chemistry 1988
Review
Topics: Aminopterin; Antineoplastic Agents; Folic Acid; Methotrexate; Molecular Structure
PubMed: 3076971
DOI: 10.1016/s0079-6468(08)70278-9 -
Canadian Medical Association Journal Mar 1957
Topics: Abortifacient Agents; Abortion, Criminal; Abortion, Induced; Abortion, Spontaneous; Aminopterin; Criminals; Female; Humans; Pregnancy
PubMed: 13413766
DOI: No ID Found -
Archives of Dermatology Jun 1961
Topics: Aminopterin; Folic Acid Antagonists; Humans; Methotrexate; Psoriasis
PubMed: 13740302
DOI: 10.1001/archderm.1961.01580120082020 -
Archives of Internal Medicine May 1963
Topics: Aminopterin; Humans; Leucovorin; Leukemia; Leukemia, Lymphoid; Meninges; Methotrexate
PubMed: 13973810
DOI: 10.1001/archinte.1963.03620290086011