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IARC Monographs on the Evaluation of... 1990
Review
Topics: Ampicillin; Animals; Carcinogens; Female; Humans; Molecular Structure; Reproduction
PubMed: 2292797
DOI: No ID Found -
The British Veterinary Journal 1994Ampicillin is an antibiotic commonly administered to horses by both the intramuscular (i.m.) and the intravenous (i.v.) route. Its physicochemical properties restrict... (Review)
Review
Ampicillin is an antibiotic commonly administered to horses by both the intramuscular (i.m.) and the intravenous (i.v.) route. Its physicochemical properties restrict its absorption after oral administration and explain its rapid elimination from the body. To prolong the effects of ampicillin in the horse, attempts have been made to alter its elimination and absorption rates. The alteration of urinary pH did not change the plasma disposition of the antibiotic but when probenecid was administered concurrently with ampicillin, a significant reduction of total body clearance was achieved. Ampicillin may also be maintained in the equine body, for a prolonged period of time when administered as an i.v. infusion. However, the practical difficulties associated with this route of administration and the limited potential advantage over conventional routes such as i.m. injection restrict its application to the critically ill animal and the perioperative period. When bacampicillin and pivampicillin (two ampicillin prodrugs) were administered to horses, high oral bioavailability was obtained, and the use of prodrugs commands the need for further investigation. The use of ampicillin might be limited in the future as an increase in the number of resistant equine bacterial strains emerge and it may be prudent to restrict its use according to the principles of good clinical pharmacological practice.
Topics: Ampicillin; Ampicillin Resistance; Animals; Bacteria; Horses; Pivampicillin; Prodrugs
PubMed: 8025849
DOI: 10.1016/S0007-1935(05)80225-8 -
Journal of the American Pharmaceutical... Oct 1975
Topics: Ampicillin; Biological Availability; Dosage Forms; Humans
PubMed: 1184921
DOI: 10.1016/s0003-0465(16)34104-0 -
British Medical Journal (Clinical... Feb 1983
Topics: Ampicillin; Humans; Kinetics
PubMed: 6402157
DOI: 10.1136/bmj.286.6365.583 -
Tidsskrift For Den Norske Laegeforening... Nov 1977
Topics: Amoxicillin; Ampicillin; Bacteria; Humans; Penicillin Resistance; Pivampicillin
PubMed: 244370
DOI: No ID Found -
Magnetic Resonance in Chemistry : MRC Feb 2020
Topics: Ampicillin; Anti-Bacterial Agents; Carbon-13 Magnetic Resonance Spectroscopy; Proton Magnetic Resonance Spectroscopy; Stereoisomerism
PubMed: 31711266
DOI: 10.1002/mrc.4963 -
British Medical Journal Jun 1970
Topics: Ampicillin; Drug Contamination; Macromolecular Substances
PubMed: 5429670
DOI: 10.1136/bmj.2.5711.735-a -
American Journal of Diseases of... Mar 1973
Topics: Ampicillin; Dysentery, Bacillary; Penicillin Resistance; Shigella
PubMed: 4487257
DOI: 10.1001/archpedi.1973.04160030108023 -
Nanotechnology May 2020Antibiotic resistance is a highly challenging concern of infectious diseases, and it requires a rational approach to overcome. Through this work, we have synthesized...
Antibiotic resistance is a highly challenging concern of infectious diseases, and it requires a rational approach to overcome. Through this work, we have synthesized ampicillin-capped gold nanoparticles (Amp-Au NPs) and studied its interaction with bacterial cells. In this process of synthesis, the primary amine group of ampicillin acts as both reducing as well as capping agent. In addition to synthesized gold nanoparticles, the β-lactam ring remains free to interact with bacteria. This approach not only utilizes the maximum efficiency of nanoparticles and antibiotics towards ampicillin sensitive bacterial cells but also proves to be effective against ampicillin resistance bacteria. Our results illustrate that the optimized system of Amp-Au NPs was formulated by taking 1.25 mM ampicillin and 10 of gold ions concentration. UV-vis spectrum of gold nanoparticles and the presence of ampicillin were recorded at around 540 nm and 259 nm, respectively. Microscopic images indicate that particles are nearly spherical and are in size range between 25 and 50 nm. Moreover, formulated Amp-Au NPs show successful accumulation onto the surface of the bacterial cell as a result of which pores were formed into the bacterial membrane. The entry of nanoparticles into bacterial cells was validated through both atomic force microscopy and fluorescent microscopy. The adhesive properties of this coating material and its stability in various pH, i.e. pH 3, pH 7 and pH 10 conditions, could make them a good candidate in the prevention of biofilm formation. Amp-Au NPs show promising antimicrobial activity against ampicillin resistance Escherichia coli bacteria. Furthermore, antimicrobial studies indicate that the efficacy of Amp-Au NPs increased against both ampicillin sensitive and ampicillin resistance bacteria up to sixteen folds and four folds respectively.
Topics: Ampicillin; Ampicillin Resistance; Escherichia coli; Gold; Hydrogen-Ion Concentration; Metal Nanoparticles; Microbial Sensitivity Tests; Microscopy, Atomic Force; Microscopy, Fluorescence; Particle Size
PubMed: 32018229
DOI: 10.1088/1361-6528/ab72b4 -
British Medical Journal May 1970
Topics: Ampicillin; Animals; Drug Hypersensitivity; Humans
PubMed: 5420185
DOI: 10.1136/bmj.2.5704.295-c