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Regulatory Peptides Nov 1995
Review
Topics: Amino Acid Sequence; Angiotensinogen; Angiotensins; Animals; Brain; Humans; Molecular Sequence Data; Receptors, Angiotensin; Renin-Angiotensin System; Signal Transduction
PubMed: 8577933
DOI: 10.1016/0167-0115(95)00084-o -
The Journal of Clinical Investigation Jan 1987
Review
Topics: Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Angiotensins; Antihypertensive Agents; Blood Pressure; Humans; RNA, Messenger; Renin; Tissue Distribution
PubMed: 3025255
DOI: 10.1172/JCI112768 -
Ceskoslovenska Fysiologie 2004Renin-angiotensin system (RAS) have been extensively studied in last few decades. RAS regulates blood pressure, water and electrolytes balance. The disorders in function... (Review)
Review
Renin-angiotensin system (RAS) have been extensively studied in last few decades. RAS regulates blood pressure, water and electrolytes balance. The disorders in function of RAS may play a potential role in development of some complex diseases like: hypertension, myocardial infarction, stroke, nephropathies and renal failure, chronic obstruction pulmonary disease and many more. RAS may take part in formation and progression of these diseases. In this work we focus on molecular biology of RAS and polymorphisms of RAS genes.
Topics: Angiotensins; Animals; Humans; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Receptors, Angiotensin; Renin-Angiotensin System
PubMed: 15704738
DOI: No ID Found -
Clinical and Experimental Hypertension.... 1988Sino-aortic denervation (SAD) in rats alters completely the pattern of pressure changes during sleep: from unchanged to a rise in SS and from slight increase to a market... (Review)
Review
Sino-aortic denervation (SAD) in rats alters completely the pattern of pressure changes during sleep: from unchanged to a rise in SS and from slight increase to a market drop in DS. Rats with mild renal hypertension (1K - 1C) behaved like normotensive rats, whereas in those rats with hypertension accompanied by overactivity of RAS, the pattern of MAP changes during sleep was similar to SAD rats. Since acute SAD also produced overactivity of RAS we studied SAD rats treated with Captopril or when RAS was normal at the chronic phase of SAD and we showed that impairment of baroreceptor function per se determines the typical alteration of BP during sleep. Intracerebral infusion of angiotensin modifies the pattern of pressure changes during sleep in a way similar to that produced by impaired baroreceptor function (SAD), probably by altering the central integration of the baroreceptor reflexes. Therefore the pattern of pressure changes during sleep seems to be a sensitive index of the functional integrity of the baroreceptor reflex.
Topics: Angiotensins; Animals; Blood Pressure; Pressoreceptors; Rats; Sleep; Sleep, REM
PubMed: 3072121
DOI: 10.3109/10641968809075967 -
Clinical Science (London, England :... Apr 2021
Topics: Angiotensinogen; Angiotensins; Blood Pressure; Brain; Desoxycorticosterone Acetate; RNA, Small Interfering
PubMed: 33835150
DOI: 10.1042/CS20210199 -
Revista Medico-chirurgicala a... 2006The present work introduces a brief review of the actual knowledge concerning the enzymes involved in the biosynthesis of the active angiotensins, followed by a... (Review)
Review
The present work introduces a brief review of the actual knowledge concerning the enzymes involved in the biosynthesis of the active angiotensins, followed by a presentation of their main physio-pharmacological actions. The enzymatic pathways that generate active ang. II (1-8) are complemented with data concerning its transformation into angiotensin III (2-8), ang. IV (3-8), ang. V (1-5) and ang. 1-7. Besides the classic renin of renal origin, the tissue isorenins, represented by tonin and cathepsins D and G, inactive angiotensin-I-forming are also reviewed. Furthermore, chymase and the new angiotensin-converting enzyme 2 (ACE2), which generates angiotensin 1-7, having opposite properties from the mother-substance (Ang. II) are discussed at length. The presentation of properties of angiotensin-generating enzymes is followed by the presentation of the action of angiotensinases (aminopetidases, carboxypeptidase and endopeptidases), which are involved both in the generation of biologically active angiotensin peptides and in their inactivation.
Topics: Aminopeptidases; Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin-Converting Enzyme 2; Angiotensinogen; Angiotensins; Antihypertensive Agents; Carboxypeptidases; Cathepsins; Chymases; Endopeptidases; Humans; Peptide Fragments; Peptidyl-Dipeptidase A; Renin; Renin-Angiotensin System; Tissue Kallikreins
PubMed: 19292099
DOI: No ID Found -
Folia Medica Neerlandica Nov 1963
Topics: Angiotensins
PubMed: 14095254
DOI: No ID Found -
Current Protein & Peptide Science Aug 2005The brain renin-angiotensin system enables the formation of different biological active forms of angiotensins within the brain. All enzymes and peptides necessary for... (Review)
Review
The brain renin-angiotensin system enables the formation of different biological active forms of angiotensins within the brain. All enzymes and peptides necessary for the biosynthesis of these angiotensins have been recognized within the central nervous system. Since there are considerable mismatches concerning the localization of the different enzymes, this system is not fully understood. Moreover, since alternative pathways of the angiotensin biosynthesis exists, localization and generation, especially of the short forms of biologically active angiotensins, are largely enigmatic. The brain renin-angiotensin system mediates several classic physiological effects including body water balance, maintenance of blood pressure, sexual behaviors, and regulation of pituitary gland hormones. Beside these classic functions, the brain renin-angiotensin system has more subtle functions involving complex mechanisms such as learning and memory. The mechanisms of action seem to differ depending on the utilized different bioactive angiotensin fragments, which are formed by the action of a variety of enzymes. This phenomenon appears to represent an important mechanism for neuromodulation. Moreover, there is evidence to suggest that the renin-angiotensin system is involved in neurological disorders, as e.g. Alzheimer's or Parkinson's disease.
Topics: Angiotensins; Animals; Brain; Brain Ischemia; Humans; Long-Term Potentiation; Neurodegenerative Diseases; Receptors, Angiotensin; Renin-Angiotensin System
PubMed: 16101434
DOI: 10.2174/1389203054546361 -
Hypertension (Dallas, Tex. : 1979) Jun 2000
Topics: Angiotensins; Humans; Intracellular Membranes; Myocardium
PubMed: 10856261
DOI: 10.1161/01.hyp.35.6.1189 -
Circulation Research Apr 1991
Review
Topics: Angiotensins; Animals; Heart; Homeostasis; Humans; Myocardial Infarction; Renin-Angiotensin System; Signal Transduction
PubMed: 2009615
DOI: 10.1161/01.res.68.4.905