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The Veterinary Clinics of North... Aug 2002The molecular basis of the pathophysiology of anhidrosis is still not well understood. Therefore, treatments are more often based on clinical impressions than on... (Review)
Review
The molecular basis of the pathophysiology of anhidrosis is still not well understood. Therefore, treatments are more often based on clinical impressions than on scientific fact. Treatment options for this condition will improve only when more is known about the molecular events that cause anhidrosis, especially as they relate to beta2-receptor dysfunction and stimulus-secretion coupling in the sweat glands of affected horses. Although this additional information is being attained, sound environmental management will continue to be a very important aspect of the treatment of horses affected with anhidrosis.
Topics: Animals; Body Temperature Regulation; Horse Diseases; Horses; Hypohidrosis; Prevalence; Sweat Glands
PubMed: 15635912
DOI: 10.1016/s0749-0739(02)00016-0 -
European Journal of Internal Medicine Mar 2022
Topics: Hot Temperature; Humans; Hypohidrosis
PubMed: 35012815
DOI: 10.1016/j.ejim.2022.01.003 -
Frontiers in Endocrinology 2022There has been limited focus on sweating failure in patients with brain tumor. We report two patients with generalized anhidrosis caused by germinoma. We also review... (Review)
Review
PURPOSE
There has been limited focus on sweating failure in patients with brain tumor. We report two patients with generalized anhidrosis caused by germinoma. We also review previous reports of generalized anhidrosis due to brain tumor.
CASE REPORTS
Patient 1 was a 12-year-old boy with repetitive heat shock-like episodes even in winter. Based on Minor's test, he was diagnosed with generalized anhidrosis. Magnetic resonance imaging (MRI) revealed the absence of high signal intensity of the posterior pituitary. He was initially diagnosed with central diabetes insipidus. However, an MRI scan performed after 3 months revealed an enlarged pituitary stalk. He was finally diagnosed with germinoma by pituitary biopsy. After chemotherapy and radiation, sweating was partially resolved. Patient 2 was a 12-year-old girl with growth hormone deficiency and generalized anhidrosis. She was diagnosed with germinoma based on MRI and pituitary biopsy findings. After chemotherapy and radiation, the sweating resolved completely.
DISCUSSION
In our literature search, we identified four patients with anhidrosis due to brain tumor, including our cases. All patients had germinoma and continued to require hormone replacement therapy after treatment of germinoma. Two patients with incomplete recovery of sweating had the involvement in the hypothalamus, whereas one patient with complete recovery showed a lack of evident hypothalamic involvement. Improvement in sweating in one patient was not described.
CONCLUSION
Germinoma can cause anhidrosis, and involvement in the hypothalamus may be relevant to incomplete recovery of sweating.
Topics: Brain Neoplasms; Child; Diabetes Insipidus, Neurogenic; Female; Germinoma; Humans; Hypohidrosis; Male; Pituitary Diseases
PubMed: 35721739
DOI: 10.3389/fendo.2022.877715 -
International Journal of Molecular... Aug 2021Acquired idiopathic generalized anhidrosis (AIGA) is a rare disorder in which systemic anhidrosis/hypohidrosis occurs without causative dermatological, metabolic or... (Review)
Review
Acquired idiopathic generalized anhidrosis (AIGA) is a rare disorder in which systemic anhidrosis/hypohidrosis occurs without causative dermatological, metabolic or neurological disorder. Most cases of AIGA have been reported in Asia, especially in Japan, but there have been only a few reports in Europe and the United States. Severe AIGA may result in heatstroke and can reduce quality of life due to restriction of exercise and outdoor works. AIGA is often accompanied by cholinergic urticaria (CholU), and it is thought that AIGA and CholU with anhidrosis/hypohidrosis belong to the same spectrum of the disease. However, the pathophysiology of AIGA has not yet been clarified. Decreased expression of cholinergic receptor M3 on the epithelial cells of eccrine sweat glands is often accompanied by T cell infiltration around eccrine apparatus, suggesting an immunological mechanism of disordered perspiration. AIGA is occasionally associated with various complications indicative of autoimmune disorders. The association of autoimmune complications further suggests that AIGA is an autoimmune disorder. Studies on complications may lead to a better understanding of the pathophysiology of AIGA.
Topics: Animals; Autoimmune Diseases; Humans; Hypohidrosis; Receptor, Muscarinic M3; Receptors, Cholinergic; Urticaria
PubMed: 34445091
DOI: 10.3390/ijms22168389 -
Muscle & Nerve May 2023
Topics: Humans; COVID-19; COVID-19 Vaccines; Hypohidrosis
PubMed: 36861924
DOI: 10.1002/mus.27810 -
Neurosciences (Riyadh, Saudi Arabia) Apr 2013
Topics: Adrenal Cortex Hormones; Adult; Humans; Hypohidrosis; Male
PubMed: 23545621
DOI: No ID Found -
Asian Cardiovascular & Thoracic Annals Feb 2016Management of pain following thoracotomy is an important issue for the control of early morbidity. We herein present the case of a patient who was referred to our... (Review)
Review
Management of pain following thoracotomy is an important issue for the control of early morbidity. We herein present the case of a patient who was referred to our hospital after a fall from a height. Right-sided multiple rib fractures, hemopneumothorax, and diaphragmatic rupture were detected. Thoracic epidural catheterization was performed for pain management just before thoracotomy. The patient developed unilateral anhidrosis postoperatively. We discuss this rare complication of thoracic epidural analgesia with a review of relevant literature.
Topics: Accidental Falls; Analgesia, Epidural; Anesthetics, Local; Humans; Hypohidrosis; Magnetic Resonance Imaging; Male; Multiple Trauma; Pain Measurement; Pain, Postoperative; Sweating; Thoracic Vertebrae; Thoracotomy; Treatment Outcome
PubMed: 26612960
DOI: 10.1177/0218492315618508 -
Veterinary Research Communications Sep 1983Anhidrosis is loss of the ability to sweat. The problem is seen in horses kept in a hot humid climate, and it may cause severe impairment of thermoregulation in the... (Review)
Review
Anhidrosis is loss of the ability to sweat. The problem is seen in horses kept in a hot humid climate, and it may cause severe impairment of thermoregulation in the equine athlete. British Thoroughbreds imported to her tropical colonies are the earliest recorded cases, and since then the syndrome has come to be described as one of Thoroughbreds, usually performance athletes, undergoing acclimatization to heat and humidity. A recent epidemiologic study of cases in Florida has shown, however, that many different breeds, and long time inhabitants of a hot climate, may be affected. Equine sweat glands are of the apocrine type, and sweating is stimulated by direct local release of epinephrine from adrenergic nerve endings and by circulating epinephrine. Lack of sweating could be due to a number of possible flaws in a sequence from central nervous stimulation through sweat stimulation and secretion to delivery of sweat to the skin surface. The most likely possibilities are inadequate sweat gland response due to habituation of receptors to a high circulating level of epinephrine and occlusion of the sweat ducts by keratin plugs. Hormonal or metabolic imbalance may play a role both in the onset and secondary signs associated with anhidrosis.
Topics: Acclimatization; Adrenergic Fibers; Animals; Body Temperature Regulation; Climate; Epinephrine; Florida; Horse Diseases; Horses; Humidity; Hypohidrosis; Physical Exertion; Sweat; Sweat Glands
PubMed: 6359664
DOI: 10.1007/BF02214921 -
American Journal of Clinical Dermatology Jan 2023Cholinergic urticaria (CholU) is a subtype of chronic inducible urticaria with a chief complaint of itching and/or stinging, painful papular wheals that develop... (Review)
Review
Cholinergic urticaria (CholU) is a subtype of chronic inducible urticaria with a chief complaint of itching and/or stinging, painful papular wheals that develop simultaneously with sweating. This review specifically focuses on several subtypes of CholU and specifically investigates the relationship between CholU and anhidrosis. We review recent publications and update the evidence around CholU, including the epidemiology, clinical features, diagnostic approaches, physiopathology, subtype classification, and therapeutic approaches. Multiple mechanisms contribute in a complex manner to the development of CholU, including histamine, sweat allergy, cholinergic-related substances, poral occlusion, and hypohidrosis/anhidrosis. A new schematic of the currently known pathological conditions has been created. Specific methods for diagnosing CholU, a provocation test, and evaluation methods for disease severity/activity and disease burden of CholU are summarized. The characteristics of the diseases that should be differentiated from CholU and examination methods are also summarized. The primary finding of this review is that CholU should be categorized based on the etiology and clinical characteristics of each subtype to properly manage and treat the disease. This categorization leads to improvement of therapeutic resistance status of this disease. In particular, a sweating abnormality should be given more attention when examining patients with CholU. Because CholU is not a homogeneous disease, its subtype classification is important for selection of the most suitable therapeutic method. Further elucidation of the pathophysiology of each subtype is expected.
Topics: Humans; Hypohidrosis; Urticaria; Sweating; Sweat; Cholinergic Agents
PubMed: 36107396
DOI: 10.1007/s40257-022-00728-6 -
Clinical and Experimental Dermatology Feb 2022
Topics: Adenocarcinoma of Lung; Aged; Antibodies, Monoclonal, Humanized; Female; Humans; Hypohidrosis; Immune Checkpoint Inhibitors; Lung Neoplasms; Skin
PubMed: 34610167
DOI: 10.1111/ced.14967