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Organic Letters Jan 2002[reaction: see text] Cationic porphyrins 1-3 bearing one, two, and four bicyclic guanidines form highly ordered chiral assemblies in aqueous solutions. The chirality is...
[reaction: see text] Cationic porphyrins 1-3 bearing one, two, and four bicyclic guanidines form highly ordered chiral assemblies in aqueous solutions. The chirality is controlled by the type of the anionic counterpart and results from a spontaneous process. The chiral assemblies of 1-3 relate structurally to the complexes of achiral porphyrins with helical DNA. However, the presence of a chiral template (DNA, poly L-Glu were tested) is not necessary for formation of these specific chiral porphyrin assemblies.
Topics: Anions; Bridged Bicyclo Compounds, Heterocyclic; Circular Dichroism; DNA; Guanidines; Indicators and Reagents; Porphyrins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Ultraviolet; Templates, Genetic
PubMed: 11772088
DOI: 10.1021/ol0168667 -
Critical Care Medicine May 1991To quantitate the contribution of lactate, phosphate, urate, total serum proteins, and unidentified anions to the anion gap in patients with severe sepsis.
OBJECTIVE
To quantitate the contribution of lactate, phosphate, urate, total serum proteins, and unidentified anions to the anion gap in patients with severe sepsis.
DESIGN
Thirty critically ill patients with evidence of severe sepsis and systemic hypoperfusion were prospectively studied.
MEASUREMENTS
The anion gap was calculated as [Na+] + [K+] - [Cl-] - [HCO3]. A corrected anion gap was calculated as the anion gap minus the anionic contribution of lactate, phosphate, urate, and total serum proteins. The corrected anion gap is a marker of unmeasured anion less unmeasured cation concentration.
RESULTS
The mean anion gap was 21.8 +/- 1.4 mmol/L and the corrected anion gap was 3.7 +/- 0.8 mmol/L. The mean arterial blood lactate concentration was 5.9 +/- 0.8 mmol/L. The magnitude of the lactate concentration correlated linearly with the anion gap (r2 = .61, lactate = 0.4 anion gap - 3.9, n = 30, p less than .01). The corrected anion gap was greater than 0 in 24 (80%) of 30 patients. The magnitude of the corrected anion gap correlated linearly with the anion gap (r2 = .66, corrected anion gap = 0.5 anion gap - 6.3, n = 30, p less than .01). Since the slope of the regression line for estimating corrected anion gap from anion gap was 0.5, the contribution of unmeasured anions was as important as lactate in determining the anion gap.
CONCLUSION
These data indicate that lactic acidosis does not entirely account for the metabolic acidosis during severe sepsis. Furthermore, the increased corrected anion gap suggests the presence of an unidentified anion (or anions) that is (or are) responsible, in large part, for the development of metabolic acidosis in patients with sepsis.
Topics: Acid-Base Equilibrium; Acidosis; Adult; Aged; Aged, 80 and over; Anions; Blood Proteins; Creatine; Female; Humans; Infections; Lactates; Lactic Acid; Male; Middle Aged; Phosphates; Uric Acid
PubMed: 2026034
DOI: 10.1097/00003246-199105000-00018 -
Chemistry, An Asian Journal Apr 2022Compound [Ag (W O )(S Bu) (CF COO) ](CF COO) ⋅ 6H O (1) was synthesized through a one-pot method. This is the first case of isolating a new silver thiolate...
Compound [Ag (W O )(S Bu) (CF COO) ](CF COO) ⋅ 6H O (1) was synthesized through a one-pot method. This is the first case of isolating a new silver thiolate cluster containing a [W O ] template which transforms from WO polyoxoanion through a self-assembly process. The anionic nature of the reduced [W O ] template and the effective silver-oxygen interaction contribute to the formation of the Ag nanowheel in 1. The luminescence, photocatalytic activity and electrochemistry properties of 1 were studied.
Topics: Anions; Luminescence; Silver
PubMed: 35191620
DOI: 10.1002/asia.202200072 -
Spectrochimica Acta. Part A, Molecular... Mar 2019Two tweezer-like anion receptors 2,2'‑bis(2‑cyano‑2‑phenylvinyl)‑5,5'‑dimethyl dipyrromethane (1) and...
Two tweezer-like anion receptors 2,2'‑bis(2‑cyano‑2‑phenylvinyl)‑5,5'‑dimethyl dipyrromethane (1) and 2,2'‑bis[2‑cyano‑2‑(4‑nitrophenyl)vinyl]‑5,5'‑dimethyl dipyrromethane (2) were synthesized in good yields, via a facile condensation of diformyldipyrromethane and the appropriate phenylacetonitrile. Anion recognition properties of these receptors were studied in detail in DMSO solution, by means of UV-vis and H NMR titration techniques. The obtained results indicated that receptor 2 containing a terminal nitro group exhibited the strong and selective binding to biologically important fluoride and dihydrogenphosphate ions over other anions. In addition, the binding strength of receptor 2 with fluoride was enhanced by a factor of 18, relative to receptor 1 lacking the nitro group. Remarkably, the presence or absence of nitro group within receptor compounds also had a great influence on the anion-binding selectivity. In particular, a distinct color change of DMSO solution of receptor 2 was observed only upon addition of fluoride, showing the potential of 2 acting as an effective colorimetric sensor for the detection of fluoride anion.
Topics: Anions; Chemistry Techniques, Synthetic; Colorimetry; Dimethyl Sulfoxide; Fluorides; Limit of Detection; Organophosphates; Proton Magnetic Resonance Spectroscopy; Pyrroles; Spectrophotometry, Ultraviolet
PubMed: 30415108
DOI: 10.1016/j.saa.2018.10.056 -
Journal of the American Chemical Society Jul 2012We demonstrate the complete exchange of the interlamellar anions of a 2-D cationic inorganic material. The α,ω-alkanedisulfonates were exchanged for...
We demonstrate the complete exchange of the interlamellar anions of a 2-D cationic inorganic material. The α,ω-alkanedisulfonates were exchanged for α,ω-alkanedicarboxylates, leading to two new cationic materials with the same [Pb(2)F(2)](2+) layered architecture. Both were solved by single crystal X-ray diffraction and the transformation also followed by in situ optical microscopy and ex situ powder X-ray diffraction. This report represents a rare example of metal-organic framework displaying highly efficient and complete replacement of its anionic organic linker while retaining the original extended inorganic layer. It also opens up further possibilities for introducing other anions or abatement of problematic anions such as pharmaceuticals and their metabolites.
Topics: Alkanesulfonates; Anions; Cations; Crystallography, X-Ray; Dicarboxylic Acids; Environmental Pollutants; Fluorides; Ion Exchange; Lead; Organometallic Compounds; X-Ray Diffraction
PubMed: 22708509
DOI: 10.1021/ja3017686 -
Molecules (Basel, Switzerland) Feb 2023A comprehensive study focused on the preparation of disubstituted carboxonium derivatives of -decaborate anion [2,6-BHOCCH] was carried out. The proposed synthesis of...
A comprehensive study focused on the preparation of disubstituted carboxonium derivatives of -decaborate anion [2,6-BHOCCH] was carried out. The proposed synthesis of the target product was based on the interaction between the anion [BH] and benzoic acid CHCOOH. It was shown that the formation of this product proceeds stepwise through the formation of a mono-substituted product [BHOC(OH)CH]. In addition, an alternative one-step approach for obtaining the target derivative is postulated. The structure of tetrabutylammonium salts of carboxonium derivative ((CH)N)[2,6-BHOCCH] was established with the help of X-ray structure analysis. The reaction pathway for the formation of [2,6-BHOCCH] was investigated with the help of density functional theory (DFT) calculations. This process has an electrophile induced nucleophilic substitution (EINS) mechanism, and intermediate anionic species play a key role. Such intermediates have a structure in which one boron atom coordinates two hydrogen atoms. The regioselectivity for the process of formation for the 2,6-isomer was also proved by theoretical calculations. Generally, in the experimental part, the simple and available approach for producing disubstituted carboxonium derivative was introduced, and the mechanism of this process was investigated with the help of theoretical calculations. The proposed approach can be applicable for the preparation of a wide range of disubstituted derivatives of -borate anions.
Topics: Borates; Anions; Boron; Isomerism
PubMed: 36838745
DOI: 10.3390/molecules28041757 -
Mitochondrion Jul 2023The antifungal activity of the drug micafungin, a cyclic lipopeptide that interacts with membrane proteins, may involve inhibition of fungal mitochondria. In humans,...
The antifungal activity of the drug micafungin, a cyclic lipopeptide that interacts with membrane proteins, may involve inhibition of fungal mitochondria. In humans, mitochondria are spared by the inability of micafungin to cross the cytoplasmic membrane. Using isolated mitochondria, we find that micafungin initiates the uptake of salts, causing rapid swelling and rupture of mitochondria with release of cytochrome c. The inner membrane anion channel (IMAC) is altered by micafungin to transfer both cations and anions. We propose that binding of anionic micafungin to IMAC attracts cations into the ion pore for the rapid transfer of ion pairs.
Topics: Humans; Micafungin; Mitochondria; Mitochondrial Membranes; Anions; Ion Channels
PubMed: 37201620
DOI: 10.1016/j.mito.2023.05.004 -
Chemistry (Weinheim An Der Bergstrasse,... Oct 2012The chiral bicyclic diguanidinium chloride 1 forms gels in aromatic apolar solvents. The gels were characterized at different levels of organization, from the...
The chiral bicyclic diguanidinium chloride 1 forms gels in aromatic apolar solvents. The gels were characterized at different levels of organization, from the macroscopic to the molecular level by using microscopy, spectroscopy, and powder X-ray diffraction. The dependency on chirality has been highlighted by circular dichroism and electron microscopy. Furthermore, the gel has been shown to be effectively responsive to anionic stimuli, thus allowing the reversible control of the organic-phase gelation in contact with different salted aqueous solutions.
Topics: Anions; Circular Dichroism; Gels; Molecular Structure; Solutions; Solvents; Spectrum Analysis; X-Ray Diffraction
PubMed: 22936304
DOI: 10.1002/chem.201200943 -
Chemical Communications (Cambridge,... Jun 2015We propose an organic field effect transistor (OFET)-based sensor design as a new and innovative platform for anion detection. OFETs could be fabricated on low-cost...
We propose an organic field effect transistor (OFET)-based sensor design as a new and innovative platform for anion detection. OFETs could be fabricated on low-cost plastic film substrates using printing technologies, suggesting that OFETs can potentially be applied to practical supramolecular anion sensor devices in the near future.
Topics: Anions; Boronic Acids; Thiophenes; Transistors, Electronic; Water
PubMed: 25966040
DOI: 10.1039/c5cc02643a -
Journal of the American Chemical Society May 2014Metal-organic frameworks (MOFs) with cationic frameworks and mobile anions have many applications from sensing, anion exchange and separation, to fast ion conductivity....
Metal-organic frameworks (MOFs) with cationic frameworks and mobile anions have many applications from sensing, anion exchange and separation, to fast ion conductivity. Despite recent progress, the vast majority of MOFs have neutral frameworks. A common mechanism for the formation of neutral frameworks is the attachment of anionic species such as F(-) or OH(-) to the framework metal sites, neutralizing an otherwise cationic scaffolding. Here, we report a general method capable of converting such neutral frameworks directly into cationic ones with concurrent generation of mobile anions. Our method is based on the differential affinity between distinct metal ions with framework anionic species. Specifically, Al(3+) is used to strip F(-) anions away from framework Cr(3+) sites, leading to cationic frameworks with mobile Cl(-) anions. The subsequent anion exchange with OH(-) further leads to a porous network with mobile OH(-) anions. New materials prepared by anion stripping can undergo ion exchange with anionic organic dyes and also exhibit much improved ionic conductivity compared to the original unmodified MOFs.
Topics: Anions; Cations; Electric Conductivity; Electrochemistry; Hydroxides; Organometallic Compounds; Surface Properties
PubMed: 24836691
DOI: 10.1021/ja5030723