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BMC Oral Health Dec 2021Traumatic haemarthrosis was hypothesized to be the etiology of temporomandibular (TMJ) ankylosis. Here, taking haematoma absorbance as a control, we aimed to reveal the...
BACKGROUND
Traumatic haemarthrosis was hypothesized to be the etiology of temporomandibular (TMJ) ankylosis. Here, taking haematoma absorbance as a control, we aimed to reveal the molecular mechanisms involved in haematoma organizing into ankylosis using transcriptome microarray profiles.
MATERIAL/METHODS
Disk removal was performed to building haematoma absorbance (HA) in one side of TMJ, while removal of disk and articular fibrous layers was performed to induced TMJ ankylosis through haematoma organization (HO) in the contralateral side in a sheep model. Haematoma tissues harvested at days 1, 4 and 7 postoperatively were examined by histology, and analyzed by Affymetrix OviGene-1_0-ST microarrays. The DAVID were recruited to perform the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis for the different expression genes (DEGs). The DEGs were also typed into protein-protein interaction (PPI) networks to get the interaction data. Six significant genes screened from PPI analysis, were confirmed by real-time PCR.
RESULTS
We found 268, 223 and 17 DEGs at least twofold at days 1, 4 and 7, respectively. At day 1, genes promoting collagen ossification (POSTN, BGN, LUM, SPARC), cell proliferation (TGF-β), and osteogenic differentiation of mesenchymal stem cells (BMP-2) were up-regulated in the HO side. At day 4, several genes involved in angiogenesis (KDR, FIT1, TEK) shower higher expression in the HO side. While HA was characterized by a continuous immune and inflammatory reaction.
CONCLUSIONS
Our results provide a comprehensive understanding of the role of haematoma in the onset and progress of TMJ ankylosis. The study will contribute to explaining why few injured TMJs ankylose and most do not from the molecular level.
Topics: Animals; Ankylosis; Hemarthrosis; Mandibular Condyle; Microarray Analysis; Osteogenesis; Sheep; Temporomandibular Joint
PubMed: 34961493
DOI: 10.1186/s12903-021-02033-w -
ASDC Journal of Dentistry For Children 1986In this case report, Twin A had four teeth ankylosed and Twin B had five teeth involved; there was a nearly identical pattern of distribution and severity of ankylosis.
In this case report, Twin A had four teeth ankylosed and Twin B had five teeth involved; there was a nearly identical pattern of distribution and severity of ankylosis.
Topics: Ankylosis; Child; Diseases in Twins; Humans; Male; Molar; Tooth Diseases; Twins; Twins, Monozygotic
PubMed: 3457036
DOI: No ID Found -
Prevalence and Associated Factors of Facet Joint Ankylosis in Patients With Axial Spondyloarthritis.The Journal of Rheumatology Jun 2023To investigate the prevalence of facet joint ankylosis in the whole spine in axial spondyloarthritis (axSpA) using low-dose computed tomography (LDCT), and to identify...
OBJECTIVE
To investigate the prevalence of facet joint ankylosis in the whole spine in axial spondyloarthritis (axSpA) using low-dose computed tomography (LDCT), and to identify factors associated with facet joint ankylosis.
METHODS
Whole spine LDCT images from 161 patients with axSpA were examined, and the presence of facet joint ankylosis was assessed (right and left, C2-S1) by 2 readers. Facet joint ankylosis was scored from 0 to 46. Structural damage of vertebral body was assessed using CT Syndesmophyte Score (CTSS). Factors associated with ankylosed facet joint scores for the whole spine were identified using a generalized linear model with a negative binomial distribution.
RESULTS
Seventy-nine patients (49%) and 70 patients (43%; reader 1 and reader 2, respectively) had ≥ 1 ankylosed facet joint. Facet joint ankylosis was most common in the thoracic spine. The mean score of facet joint ankylosis for the whole spine was 6.6 (SD 11.2) in reader 1 and 4.2 (SD 8.4) in reader 2. Whole spine facet joint ankylosis score positively correlated with Ankylosing Spondylitis Disease Activity Score (ASDAS) and CTSS. In multivariable analysis, the ankylosed facet joint score was associated with ASDAS, sacroiliitis, CTSS, and a history of uveitis in both readers. Uveitis history, ASDAS, and CTSS were associated with whole spine facet joint ankylosis score in subgroup analysis of only radiographic axSpA.
CONCLUSION
The prevalence of ankylosed facet joints is high in axSpA, especially in the thoracic segment. The whole spine ankylosed facet joint score is significantly associated with a history of uveitis, ASDAS, sacroiliitis, and syndesmophyte score.
Topics: Humans; Zygapophyseal Joint; Sacroiliitis; Prevalence; Spondylitis, Ankylosing; Spine; Spondylarthritis; Sacroiliac Joint
PubMed: 36642426
DOI: 10.3899/jrheum.220749 -
Journal of Oral and Maxillofacial... Jun 2011This article studies the classification of traumatic temporomandibular joint (TMJ) ankylosis based on coronal computed tomographic (CT) scan and presents our treatment...
OBJECTIVE
This article studies the classification of traumatic temporomandibular joint (TMJ) ankylosis based on coronal computed tomographic (CT) scan and presents our treatment experience in the TMJ division of Shanghai Ninth People's Hospital.
PATIENTS AND METHODS
From 2001 to 2009, 130 patients diagnosed with TMJ ankylosis were treated in the TMJ division. Among them, 84 patients with 124 joint injuries caused by trauma were treated first by our group of surgeons and were included in this study. All of them had CT scans, especially coronal reconstruction through the TMJ area before and after surgery. A new classification based on the coronal CT scan was proposed: type A1 is fibrous ankylosis without bony fusion of the joint; type A2 is ankylosis with bony fusion on the lateral side of the joint, while the residual condyle fragment is bigger than 0.5 of the condylar head in the medial side; type A3 is similar to A2 but the residual condylar fragment is smaller than 0.5 of the condylar head; type A4 is ankylosis with complete bony fusion of the joint. Our treatment protocol for type A1 ankylosis is fibrous tissue release or condylar head resection with costochondral graft (CCG) and temporalis myofascial flap (TMF). For type A2 and A3 ankylosis, the lateral bony fusion is resected, while the intact residual condylar fragment, displaced medially, is retained. We call it "lateral arthroplasty" (LAP). TMF or masseter muscle flap (MMF) is used as a barrier in the lateral gap between the TMJ fossa and the stump of the mandibular ramus. If the medial condylar fragment in type A3 ankylosis is too small to bear the load, it is resected with the bony mass. The joint is then reconstructed with CCG and TMF or MMF. For type A4 ankylosis, the bony fusion is completely removed and the joint is reconstructed with CCG and TMF or MMF. The result of the treatment was evaluated by CT scan and clinical follow-up.
RESULTS
Among the 124 ankylotic joints, there were 14 type A1 ankylosis (11.3%); 43 type A2 ankylosis (34.7%); 46 type A3 ankylosis (37.1%); and 21 type A4 ankylosis (16.9%). Part of type A1, and all of type A2 and A3 ankylosis had the residual condylar head displaced medially, which accounted for 75% (93/124) of the TMJ ankylosis. Eighty-two joints (66.1%) had LAP treatment; 33 joints (26.6%) had CCG joint reconstruction; and 3 joints (2.4%) had TMJ fibrous tissue release. In our case, 1 joint (0.8%) had condylectomy and TMF; 3 joints (2.4%) with fibrous ankylosis had mouth opening treatment; and 2 joints had gap arthroplasty (1.6%). Forty-eight patients with 68 joints had long follow-ups from 10 months to 4 years. Among them, 4 of 17 joints reconstructed with CCG had reankylosis (23.5%), and 7 of 48 joints treated with LAP had reankylosis (14.6%).
CONCLUSIONS
The new classification of TMJ ankylosis based on coronal CT scan is valuable in guiding clinical treatment. LAP with TMF is a good way to treat traumatic TMJ ankylosis when the medially displaced condylar head and disc are intact. CCG with TMF has a good result for type A4 ankylosis.
Topics: Adolescent; Adult; Aged; Ankylosis; Child; Child, Preschool; Female; Humans; Male; Middle Aged; Recurrence; Temporomandibular Joint; Temporomandibular Joint Disorders; Tomography, X-Ray Computed; Young Adult
PubMed: 21295900
DOI: 10.1016/j.joms.2010.07.070 -
Clinics in Orthopedic Surgery Sep 2016This case demonstrates a rarely reported bilateral scapulohumeral bony ankylosis. A young woman developed extensive heterotopic ossifications (HOs) in both shoulder...
This case demonstrates a rarely reported bilateral scapulohumeral bony ankylosis. A young woman developed extensive heterotopic ossifications (HOs) in both shoulder joints after being mechanically ventilated for several months at the intensive care unit in a comatose status. She presented with a severe movement restriction of both shoulder joints. Surgical resection of the bony bridges was performed in 2 separate sessions with a significant improvement of shoulder function afterwards. No postoperative complications, pain, or recurrence of HOs were noted at 1-year follow-up. Mechanical ventilation, immobilization, neuromuscular blockage, and prolonged sedation are known risk factors for the development of HOs in the shoulder joints. Relatively early surgical resection of the HOs can be performed safely in contrary to earlier belief. Afterwards, nonsteroidal anti-inflammatory drugs and/or radiation therapy can be possible treatment modalities to prevent recurrence of HOs.
Topics: Adult; Ankylosis; Female; Humans; Magnetic Resonance Imaging; Range of Motion, Articular; Respiration, Artificial; Shoulder Joint; Tomography, X-Ray Computed
PubMed: 27583120
DOI: 10.4055/cios.2016.8.3.339 -
International Journal of Oral and... Oct 2023The aim of this study was to determine whether there are any differences in morphology between temporomandibular joint ankylosis (TMJA) of traumatic and infective...
The aim of this study was to determine whether there are any differences in morphology between temporomandibular joint ankylosis (TMJA) of traumatic and infective origin. Cone beam computed tomography (CBCT) scans of 25 patients (28 joints) with TMJA of traumatic origin (trauma group) and 15 patients (15 joints) with TMJA of infectious origin (infection group) were included. The following morphological parameters were evaluated on multiple sections of the CBCT scans: lateral juxta-articular bone growth, residual condyle, residual glenoid fossa, ramus thickening, ankylotic mass fusion line, sclerosis of the ankylosed condyle and spongiosa of the glenoid fossa, and mastoid and glenoid fossa air cell obliteration. Lateral juxta-articular bone growth, juxta-articular extension of fusion, and the presence of normal medial residual condyle and residual glenoid fossa were exclusively found in post-traumatic TMJA. There were differences in ramus thickening (82.1% in trauma vs 53.3% in infection), sclerosis of the ankylosed condyle (100% in trauma vs 60% in infection), and sclerosis of the spongiosa of the glenoid fossa (100% in trauma vs 46.7% in infection) between the trauma and infection groups. Mastoid and glenoid fossa air cell obliteration was found more frequently in the infection group (mastoid obliteration: 23.1% in infection vs 4% in trauma; glenoid obliteration: 66.7% in infection vs 55.6% in trauma ). CBCT imaging can be helpful in differentiating between TMJA of traumatic and infectious origin.
Topics: Humans; Temporomandibular Joint; Mandibular Condyle; Sclerosis; Cone-Beam Computed Tomography; Ankylosis
PubMed: 36739205
DOI: 10.1016/j.ijom.2023.01.009 -
Oral Surgery, Oral Medicine, and Oral... Dec 1991Seventy-five condylectomy and coronoidectomy specimens of temporomandibular joint ankylosis in 61 patients were studied. Fourteen patients had bilateral ankylosis, six...
Seventy-five condylectomy and coronoidectomy specimens of temporomandibular joint ankylosis in 61 patients were studied. Fourteen patients had bilateral ankylosis, six of whom had fibrous ankylosis on one side. There were two types of ankyloses: intra-articular and juxta-articular. Intra-articular ankylosis was seen only in reankylosis or in postinfective cases. Sixty-six cases were posttraumatic juxta-articular ankylosis. A rudimentary temporomandibular joint with an atrophic condylar articular surface was found in all juxta-articular ankyloses. The size of new bone in the specimens varied from 0.5 to 3 cm. Fusion of the extra-articular bone mass with tympanic plate was also observed. Contracture of temporalis muscle was noted in all the cases, which made excision of the coronoid processes mandatory in all the arthroplasties. Arthroplasty early in childhood did not hamper growth; instead, facial remodeling was enhanced.
Topics: Ankylosis; Arthroplasty; Child; Contracture; Humans; India; Mandibular Condyle; Masseter Muscle; Recurrence; Temporal Muscle; Temporomandibular Joint Disorders
PubMed: 1812446
DOI: 10.1016/0030-4220(91)90006-x -
Oral Surgery, Oral Medicine, and Oral... Feb 1974
Review
Topics: Adult; Ankylosis; Atrophy; Bone Resorption; Denture, Complete, Lower; Humans; Male; Mandibular Diseases; Mastication; Masticatory Muscles; Osteotomy; Prognosis; Radiography; Temporomandibular Joint
PubMed: 4589358
DOI: 10.1016/0030-4220(74)90412-5 -
Journal of Oral Surgery (American... Oct 1975The factors predisposing to ankylosis and the probable pathogenesis are discussed, as treatment, both past and present. Arthroplasty with Silastic interposition is... (Review)
Review
The factors predisposing to ankylosis and the probable pathogenesis are discussed, as treatment, both past and present. Arthroplasty with Silastic interposition is presented as an acceptable means of managing ankylosis, as shown in two case reports. The ultimate postoperative result is dependent on surgical timing, surgical technique, and attention to postsurgical physiotherapy.
Topics: Adolescent; Ankylosis; Arthritis; Arthritis, Infectious; Arthroplasty; Diagnosis, Differential; Humans; Jaw Neoplasms; Joint Prosthesis; Male; Physical Therapy Modalities; Postoperative Care; Radiography; Silicone Elastomers; Temporomandibular Joint
PubMed: 1100792
DOI: No ID Found -
Australian Dental Journal Feb 1978
Topics: Adolescent; Adult; Anesthesia, General; Ankylosis; Child; Diagnosis, Differential; Facial Nerve Injuries; Female; Humans; Male; Middle Aged; Postoperative Complications; Temporomandibular Joint; Tracheotomy
PubMed: 274930
DOI: 10.1111/j.1834-7819.1978.tb02873.x