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Vestnik Otorinolaringologii 2022During SARS-CoV-2 pandemic number of patients with olfactory disorders caused by new coronavirus infection substantially increased, making their rehabilitation an issue...
During SARS-CoV-2 pandemic number of patients with olfactory disorders caused by new coronavirus infection substantially increased, making their rehabilitation an issue of the day. We analyzed influence of the drug Sinupret on the restoration dynamic of the olfactory dysfunction associated with SARS-CoV-2 infection. 187 patients with impaired sense of smell associated with SARS-CoV-2 infection were included in this study: test group consisted of 104 cases in which olfactory training methods were combined with the prescription of the drug Sinupret. Control group consisted of 84 patients those undergone olfactory training alone. During study period in 26 patients restoration of the olfactory disorders have not been achieved, due to the virus induced neurodegenerative nature of the lesion. It was observed that in test group odor detection threshold restoration was on average 3.6 days faster than in control group. At the same time, the use of Sinupret was associated with a statistically significant 29.4% decrease of antibiotic prescription frequency for bacterial complications of SARS-CoV-2. Therefore, we assume that the positive effect of Sinupret on SARS-CoV-2 associated anosmia is caused by its antiviral, secretolytic, anti-inflammatory, decongestant and moderately antibacterial effects in the olfactory epithelium.
Topics: Anosmia; COVID-19; Humans; SARS-CoV-2
PubMed: 35274890
DOI: 10.17116/otorino20228701133 -
AJNR. American Journal of Neuroradiology Jan 2021
Topics: Anosmia; COVID-19; Humans; Magnetic Resonance Imaging; Olfactory Bulb; SARS-CoV-2
PubMed: 33272952
DOI: 10.3174/ajnr.A6943 -
ORL; Journal For Oto-rhino-laryngology... 2022
Topics: Anosmia; COVID-19; Humans; SARS-CoV-2; Smell
PubMed: 35354144
DOI: 10.1159/000523785 -
Infection Apr 2021
Topics: Adult; Anosmia; COVID-19; COVID-19 Nucleic Acid Testing; Dysgeusia; Female; Humans; Male; Middle Aged; Outpatients; SARS-CoV-2; Sensitivity and Specificity
PubMed: 32410112
DOI: 10.1007/s15010-020-01442-3 -
Headache Sep 2020
Topics: Adult; Anosmia; COVID-19; COVID-19 Nucleic Acid Testing; Diarrhea; Facial Pain; Fatigue; Female; Headache Disorders, Secondary; Humans; Magnetic Resonance Imaging; Migraine Disorders; Myalgia; Nasal Cavity; SARS-CoV-2; Sensation Disorders
PubMed: 32790179
DOI: 10.1111/head.13941 -
Journal of Internal Medicine Aug 2021Click here to view the Brief Report by Lechien et al.
Click here to view the Brief Report by Lechien et al.
Topics: Anosmia; COVID-19; Humans; Olfaction Disorders; SARS-CoV-2
PubMed: 33462906
DOI: 10.1111/joim.13247 -
The Pan African Medical Journal 2020COVID-19 pandemic touch all part of world to the date more than fifteen millions of patients are infected by virus including about 1,388,926 deaths (European Centre for...
COVID-19 pandemic touch all part of world to the date more than fifteen millions of patients are infected by virus including about 1,388,926 deaths (European Centre for Disease Prevention and Control an agency of the European Union). Morocco has put in place strict containment measures to control the disease and prevent the saturation of health systems. One of the great difficulties is to quickly identify asymptomatic and paucisymptomatic cases which function as an important vector of contagion. Anosmia and fever are one of revealed mode for the young patient but is not all the case. We report one case in the sense. A 40-year-old man without medical history was admitted in the hospital after complaining 3 days ago clinical symptoms of fever, cough, headache and anosmia. Immediately, the patient benefits of COVID-19 protocol, measure of fever, nasal swab and polymerase chain reaction (PCR) test. Despite the negativity of PCR test of COVID-19, the patient was placed in isolation. Two days later, he presented a generalized seizures, then we performed a cerebral computed tomography scan (CT scan) which showed a bilateral frontal oedema. The cerebral magnetic resonance imaging (MRI) revealed the presence of 4x4x4 cm well enhanced meningeal extra axial mass of the anterior skull base with peri-tumoral oedema corresponding to an olfactory groove meningioma. The tumour was totally resected through a left fronto-lateral approach. The postoperative courses were uneventful with the persistence of totally anosmia.
Topics: Adult; Anosmia; COVID-19; Cough; Fever; Headache; Humans; Magnetic Resonance Imaging; Male; Meningeal Neoplasms; Meningioma; Morocco; Polymerase Chain Reaction; Tomography, X-Ray Computed
PubMed: 33796184
DOI: 10.11604/pamj.2020.37.371.27014 -
Brain Topography May 2020Patients with anosmia exhibit structural and functional brain abnormalities. The present study explored changes in brain white matter (WM) in non-neurodegenerative...
Patients with anosmia exhibit structural and functional brain abnormalities. The present study explored changes in brain white matter (WM) in non-neurodegenerative anosmia using diffusion-tensor-based network analysis. Twenty patients with anosmia and sixteen healthy controls were recruited in the cross-sectional, case-control study. Participants underwent olfactory tests (orthonasal and retronasal), neuropsychological assessment (cognitive function and depressive symptoms) and diffusion tensor imaging measurement. Tract-Based Spatial Statistics, graph theoretical analysis and Network-Based Statistics were used to explore the white matter. There was no significant difference in fractional anisotropy (FA) between patients and controls. In global network topological properties comparisons, patients exhibited higher γ and λ levels than controls, and both groups satisfied the criteria of small-world (σ > 1). In local network topological properties, patients had reduced betweenness, degree and efficiency (global and local), as well as increased shortest path length and cluster coefficient in olfactory-related brain areas (anterior cingulum, lenticular nucleus, putamen, hippocampus, amygdala, caudate nucleus, orbito-frontal gyrus). Olfactory threshold scores and the retronasal score were negatively correlated with γ and λ, and the retronasal score was positively correlated with FA values in certain WM tracts, i.e. middle cerebellar peduncle, right inferior cerebellar peduncle, left inferior cerebellar peduncle, right cerebral peduncle, left cerebral peduncle, left cingulum (cingulate gyrus), right cingulum (hippocampus), superior fronto-occipital fasciculus, and, left tapetum. Patients with anosmia demonstrated relevant WM network dysfunction though their structural integrity remained intact. Their retronasal olfaction deficits revealed to be more strongly associated with WM alterations compared with orthonasal olfactory scores.
Topics: Anisotropy; Anosmia; Brain; Case-Control Studies; Cross-Sectional Studies; Diffusion Tensor Imaging; Humans
PubMed: 32297077
DOI: 10.1007/s10548-020-00769-2 -
Physiology & Behavior May 2020Specific anosmia is defined as the inability to detect a particular odorant, despite a normal olfactory function. Previous studies reported sex-related difference in...
Specific anosmia is defined as the inability to detect a particular odorant, despite a normal olfactory function. Previous studies reported sex-related difference in detection threshold to steroid odorants, like androstenone or androstadienone during adolescence, and boys showed an increased detection threshold with age. However, such investigations have not been performed for non-steroid odorants. Hence, the current study investigated sex- and age-related effects on the prevalence of specific anosmia in children/adolescents aged 5-14 years (n = 800) to non-steroid odorants. The detection thresholds of three non-steroid odorants (bacdanol, methylsalicylate, and 3-hydrox-2-methyl-4-pyrone) with different molecular weights were measured. Results indicate that the rate of specific anosmia for all three odorants decreases from childhood to adolescence. This decrease is independent of sex and is most pronounced for odorants with higher molecular weight compared to the odorant with lower molecular weight. Thus, the development of basic olfactory functions for these three odorants continues until adolescence. The effect of molecular weight suggests that the locus of effect is at the periphery of the olfactory system, due to changes in either olfactory receptor expression patterns or perireceptor events.
Topics: Adolescent; Anosmia; Child; Child, Preschool; Humans; Male; Odorants; Prevalence; Sensory Thresholds; Smell; Steroids
PubMed: 32061678
DOI: 10.1016/j.physbeh.2020.112833 -
Journal of Neuroscience Research Jun 2022Loss of olfaction, or anosmia, frequently accompanies emotional dysfunctions, partly due to the overlapping brain regions between the olfactory and emotional processing...
Loss of olfaction, or anosmia, frequently accompanies emotional dysfunctions, partly due to the overlapping brain regions between the olfactory and emotional processing centers. Here, we investigated whether anosmia was associated with gray matter volume alterations at a network level, and whether these alterations were related to the olfactory-specific quality of life (QOL) and depressive symptoms. Structural brain magnetic resonance imaging was acquired in 22 individuals with postinfectious or idiopathic anosmia (the anosmia group) and 30 age- and sex-matched controls (the control group). Using independent component analysis on the gray matter volumes, we identified 10 morphometric networks. The gray matter volumes of these networks were compared between the two groups. Olfactory-specific QOL and depressive symptoms were assessed by self-report questionnaires and clinician-administered interviews, respectively. The anosmia group showed lower gray matter volumes in the hippocampus-amygdala and the precuneus networks, relative to the control group. Lower gray matter volumes in the hippocampus-amygdala network were also linearly associated with lower olfactory-specific QOL and higher depressive symptom scores. These findings suggest a close relationship between anosmia and gray matter volume alterations in the emotional brain networks, albeit without determined causal relations.
Topics: Adult; Anosmia; Brain; Gray Matter; Humans; Magnetic Resonance Imaging; Quality of Life
PubMed: 35240720
DOI: 10.1002/jnr.25037