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British Journal of Industrial Medicine Sep 1986
Topics: Adult; Aged; Anthracosilicosis; Ceruloplasmin; Coal Mining; Humans; L-Lactate Dehydrogenase; Male; Middle Aged; Peptidyl-Dipeptidase A; Tuberculosis, Pulmonary
PubMed: 3019381
DOI: 10.1136/oem.43.9.642 -
Medizinische Klinik Feb 1971
Review
Topics: Anthracosilicosis; Anti-Bacterial Agents; Blood Gas Analysis; Bronchitis; Digitalis Glycosides; Electrocardiography; Germany, West; Glucocorticoids; Humans; Hypoxia; Metaproterenol; Mining; Occupational Diseases; Oxygen Consumption; Radiography; Respiratory Function Tests; Silicosis; Socioeconomic Factors
PubMed: 4926067
DOI: No ID Found -
Mutagenesis Apr 2018Anthracosilicosis (AS), a prevalent form of pneumoconiosis among coal miners, results from the accumulation of carbon and silica in the lungs from inhaled coal dust....
Associations of polymorphisms in the cytokine genes IL1β (rs16944), IL6 (rs1800795), IL12b (rs3212227) and growth factor VEGFA (rs2010963) with anthracosilicosis in coal miners in Russia and related genotoxic effects.
Anthracosilicosis (AS), a prevalent form of pneumoconiosis among coal miners, results from the accumulation of carbon and silica in the lungs from inhaled coal dust. This study investigated genotoxic effects and certain cytokine genes polymorphic variants in Russian coal miners with АS. Peripheral leukocytes were sampled from 129 patients with AS confirmed by X-ray and tissue biopsy and from 164 asymptomatic coal miners. Four single-nucleotide polymorphisms were genotyped in the extracted DNA samples: IL1β T-511C (rs16944), IL6 C-174G (rs1800795), IL12b A1188C (rs3212227) and VEGFA C634G (rs2010963). Genotoxic effects were assessed by the analysis of chromosome aberrations in cultured peripheral lymphocytes. The mean frequency of chromatid-type aberrations and chromosome-type aberrations, namely, chromatid-type breaks and dicentric chromosomes, was found to be higher in AS patients [3.70 (95% confidence interval {CI}, 3.29-4.10) and 0.28 (95% CI, 0.17-0.38)] compared to the control group [2.41 (95% CI, 2.00-2.82) and 0.09 (95% CI, 0.03-0.15)], respectively. IL1β gene T/T genotype (rs16944) was associated with AS [17.83% in AS patients against 4.35% in healthy donors, odds ratio = 4.77 (1.88-12.15), P < 0.01]. A significant increase in the level of certain chromosome interchanges among AS donors is of interest because such effects are typical for radiation damage and caused by acute oxidative stress. IL1β T allele probably may be considered as an AS susceptibility factor among coal miners.
Topics: Adult; Anthracosilicosis; Chromosome Aberrations; Coal; Coal Mining; DNA Damage; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-12 Subunit p40; Interleukin-1beta; Interleukin-6; Male; Middle Aged; Miners; Occupational Exposure; Polymorphism, Single Nucleotide; Silicon Dioxide; Vascular Endothelial Growth Factor A
PubMed: 29378067
DOI: 10.1093/mutage/gex047 -
Current Topics in Pathology. Ergebnisse... 1971
Review
Topics: Adult; Age Factors; Aged; Air Pollution; Anthracosilicosis; Bronchitis; Carbon; Coal Mining; Humans; Life Expectancy; Macrophages; Male; Middle Aged; Occupational Diseases; Pulmonary Emphysema; Pulmonary Heart Disease; Silicon Dioxide; Time Factors
PubMed: 4333700
DOI: 10.1007/978-3-642-65208-0_2 -
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing... Oct 2005To investigate the clinicopathological characteristics of anthracosilicosis complicated with lung cancer.
OBJECTIVE
To investigate the clinicopathological characteristics of anthracosilicosis complicated with lung cancer.
METHODS
Tissue specimens from 16 autopsy cases of 0(+) anthracosilicosis complicated with lung cancer were retrospectively studied by hematoxylin-eosin, histochemical, and immunohistochemical staining.
RESULTS
All of 16 patients were male. The patient's age ranged from 46 to 57 years (average: 52.8 years). The dust-exposure time were over 25 years. The pneumoconiosis and dust fibrosis of different degrees in the lung were found. The positive detected rate of coal silicotic nodules was 93.75% (15/16). Among 16 cases of lung cancer, there were 5 cases of squamous cell carcinoma, and 5 cases of small cell undifferentiated carcinoma, 3 cases of bronchioloalveolar carcinoma, 2 cases of adenocarcinoma and 1 case of adenosquamous carcinoma. The typical pathological changes of anthracosilicosis complicated with lung cancer were: the cancer tissue was located at the side of coal dust fibrous focus and fibrosis lesion, or mixte with silicotic lesion. CK, EMA and CEA were positively expressed in most of the tumor cells, while vimentin was positive in the fibrocyte of dust fibrosis.
CONCLUSIONS
The occurrence of some lung cancer may be related with fibrosis. The dust-exposed workers can suffer from lung cancer which is histologically identical to the general lung tumor. PCNA and Ki67 may be a prognostic index for anthracosilicosis with lung cancer, while vimentin may be a marker for the examination of dust fibrosis in anthracosilicosis.
Topics: Anthracosilicosis; Humans; Lung; Lung Neoplasms; Male; Middle Aged
PubMed: 16266508
DOI: No ID Found -
Pielegniarka I Polozna 1977
Topics: Anthracosilicosis; Asbestosis; Bird Fancier's Lung; Farmer's Lung; Humans; Pneumoconiosis; Siderosis; Silicosis
PubMed: 587397
DOI: No ID Found -
Meditsinskaia Sestra Jan 1976
Topics: Anthracosilicosis; Humans; Pneumoconiosis; Silicosis
PubMed: 1044966
DOI: No ID Found -
Bulletin Mensuel - Societe de Medecine... Nov 1954
Topics: Anthracosilicosis; Disease; Humans; Military Personnel; Silicosis
PubMed: 13230749
DOI: No ID Found -
Archives of Environmental Health Jun 1961
Topics: Anthracosilicosis; Humans; Lung Diseases; Osteonecrosis
PubMed: 13776230
DOI: 10.1080/00039896.1961.10662915 -
A.M.A. Archives of Industrial Hygiene... Apr 1953
Topics: Anthracosilicosis; Humans; Silicosis
PubMed: 13039590
DOI: No ID Found