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Transplantation Proceedings 1999
Topics: Antilymphocyte Serum; Awards and Prizes; Bone Marrow Transplantation; History, 20th Century; Humans; Immunosuppressive Agents; Societies, Medical; Transplantation, Homologous; United Kingdom; United States
PubMed: 10083013
DOI: 10.1016/s0041-1345(98)02108-3 -
Laval Medical Apr 1970
Comparative Study
Topics: Animals; Antilymphocyte Serum; Immunosuppressive Agents; Rabbits; Rats; Skin Transplantation; Transplantation Immunology; Transplantation, Homologous
PubMed: 4929813
DOI: No ID Found -
The New England Journal of Medicine Jul 1971
Review
Topics: Animals; Antibody Formation; Antigens; Antilymphocyte Serum; Blood Cell Count; Graft vs Host Reaction; Haplorhini; Histocompatibility; Horses; Humans; Hypersensitivity; Immunization; Immunosuppression Therapy; Immunosuppressive Agents; Injections, Intramuscular; Injections, Intravenous; Injections, Subcutaneous; Iodine Isotopes; Kidney Transplantation; Lymphocyte Activation; Lymphocytes; Lymphopenia; Methods; Multiple Sclerosis; Rabbits; Skin Transplantation; Tissue Survival; Transplantation, Homologous; gamma-Globulins
PubMed: 4103453
DOI: 10.1056/NEJM197107152850310 -
The Laryngoscope Feb 1972
Topics: Ammonium Sulfate; Animals; Antigen-Antibody Reactions; Antilymphocyte Serum; Chemical Precipitation; Chemistry Techniques, Analytical; Chromatography, DEAE-Cellulose; Dogs; Electrophoresis, Disc; Immunodiffusion; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Larynx; Transplantation Immunology; Transplantation, Homologous
PubMed: 4622551
DOI: 10.1288/00005537-197202000-00012 -
Transplant Immunology Jun 1994
Review
Topics: Animals; Antilymphocyte Serum; Cross Reactions; Humans
PubMed: 7953314
DOI: 10.1016/0966-3274(94)90049-3 -
Cells Oct 2021Idiopathic acquired aplastic anemia can be successfully treated with Anti Thymocyte Globulin (ATG)-based immune suppressive therapy and is therefore considered a T... (Review)
Review
Idiopathic acquired aplastic anemia can be successfully treated with Anti Thymocyte Globulin (ATG)-based immune suppressive therapy and is therefore considered a T cell-mediated auto immune disease. Based on this finding, several other forms of idiopathic acquired bone marrow failure are treated with ATG as well. For this review, we extensively searched the present literature for evidence that ATG can lead to enduring remissions in different forms of acquired multi- or single-lineage bone marrow failure. We conclude that ATG-based therapy can lead to an enduring hematopoietic response and increased overall survival (OS) in patients with acquired aplastic aplasia. In patients with hypocellular myelodysplastic syndrome, ATG can lead to a hematological improvement without changing the OS. ATG seems less effective in acquired single-lineage failure diseases like Pure Red Cell Aplasia, Amegakaryocytic Thrombocytopenia and Pure White Cell Aplasia, suggesting a different pathogenesis in these bone marrow failure states compared to aplastic anemia. T cell depletion is hypothesized to play an important role in the beneficial effect of ATG but, as ATG is a mixture of polyclonal antibodies binding to different antigens, other anti-inflammatory or immunomodulatory effects could play a role as well.
Topics: Adult; Antilymphocyte Serum; Bone Marrow; Bone Marrow Failure Disorders; Humans; Prospective Studies
PubMed: 34831130
DOI: 10.3390/cells10112905 -
American Journal of Transplantation :... Mar 2014
Topics: Animals; Antilymphocyte Serum; Humans; T-Lymphocytes
PubMed: 24447779
DOI: 10.1111/ajt.12622 -
American Journal of Transplantation :... Mar 2014
Topics: Animals; Antilymphocyte Serum; Humans; T-Lymphocytes
PubMed: 24447720
DOI: 10.1111/ajt.12621 -
Archives Belges de Dermatologie Et de... 1968
Topics: Antilymphocyte Serum; Humans
PubMed: 5757959
DOI: No ID Found -
Transplantation Proceedings Mar 1975
Topics: Animals; Antilymphocyte Serum; Dogs; Graft Survival; Humans; Immunosuppression Therapy
PubMed: 1053513
DOI: No ID Found