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Rheumatology (Oxford, England) Oct 2001
Topics: Antilymphocyte Serum; Humans; Scleroderma, Systemic
PubMed: 11600753
DOI: 10.1093/rheumatology/40.10.1192 -
The Lancet. Haematology Feb 2022
Topics: Antilymphocyte Serum; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans
PubMed: 35114156
DOI: 10.1016/S2352-3026(21)00383-5 -
Experimental studies relating to the production and clinical testing of anti-human lymphocyte serum.The Medical Journal of Australia Aug 1969
Review
Topics: Animals; Antigen-Antibody Reactions; Antilymphocyte Serum; Autoimmune Diseases; Chromium Isotopes; Horses; Humans; Immune Sera; Immune Tolerance; Immunosuppressive Agents; Lymphocytes; Mice; Opsonin Proteins; Thymectomy; Thymus Gland; Transplantation Immunology
PubMed: 4898058
DOI: 10.5694/j.1326-5377.1969.tb107193.x -
Transplantation and Cellular Therapy Sep 2021
Topics: Antilymphocyte Serum; Cyclophosphamide; Humans; Unrelated Donors
PubMed: 34452719
DOI: 10.1016/j.jtct.2021.08.004 -
Federation Proceedings 1970
Topics: Animals; Antigens; Antilymphocyte Serum; Chromatography; Complement System Proteins; Culture Techniques; Electrophoresis; Hemagglutination Tests; Histocompatibility; Horses; Humans; Immune Tolerance; Injections, Intravenous; Iodine Isotopes; Kidney Transplantation; Liver Transplantation; Lymphocyte Activation; Lymphocytes; Multiple Sclerosis; Pancreas Transplantation; Skin Transplantation; Species Specificity; Transplantation Immunology; Transplantation, Homologous; gamma-Globulins
PubMed: 4189495
DOI: No ID Found -
Transactions of the New York Academy of... Nov 1973
Topics: Animals; Antigens, Fungal; Antilymphocyte Serum; Asthenia; Coccidioides; Guinea Pigs; Skin Tests; Tuberculin
PubMed: 4518582
DOI: 10.1111/j.2164-0947.1973.tb01530.x -
Revue Medicale de Bruxelles Nov 1988
Topics: Antibodies, Monoclonal; Antilymphocyte Serum; Humans; Immunosuppression Therapy; Kidney Transplantation
PubMed: 3065882
DOI: No ID Found -
Progress in Immunobiological... 1970
Topics: Animals; Antilymphocyte Serum; Dogs; Hemagglutination Tests; Horses; Kidney Transplantation; Leukocyte Count; Lymphocytes; Spleen; Thymus Gland; Transplantation Immunology; Transplantation, Homologous
PubMed: 4921387
DOI: No ID Found -
Zhongguo Dang Dai Er Ke Za Zhi =... Dec 2006Immunsuppressive therapy is a major therapy for severe aplastic anemia, and antithymocyte /antilymphocyte globulin (ATG/ALG) is usually used. This study investigated the...
OBJECTIVE
Immunsuppressive therapy is a major therapy for severe aplastic anemia, and antithymocyte /antilymphocyte globulin (ATG/ALG) is usually used. This study investigated the therapeutic effect of ATG/ALG on severe aplastic anemia and explored the management of therapy-related complications.
METHODS
Clinical data of 28 children with severe aplastic anemia who received ATG/ALG treatment from December, 1994 through to September, 2005 were analyzed retrospectively.
RESULTS
Of the 28 patients, 2 were nearly cured (7.1%), 4 were relieved (14.3%) and 12 were improved (42.9%) based on a hemoglobin/white blood cell/platelet count. These results represented an overall effective rate of 64.3%. Clinical evidence of serum sickness developed in 19 patients, manifesting as fever (n = 9), cutaneous eruptions (n = 12), arthralgias (n = 7), myalgia (n = 7) and arthrocele (n = 3). Serum sickness occurred 5-17 days after ATG/ALG administration and lasted for 1-15 days (mean 4.4 days). Three children with mild serum sickness symptoms recovered without any treatment. The symptoms of the other 16 patients disappeared after 3-5 days of methylprednisolone treatment (10 mg/kg daily). However, 3 patients had relapses at 2-4 days after termination of methylprednisolone therapy. Another course of methylprednisolone therapy was administered to the 3 patients until the symptoms disappeared. The patients with no serum sickness or with mild serum sickness had a better response to ATG/ALG therapy than those who had severe serum sickness (100% vs 60%; P < 0.05).
CONCLUSIONS
ATG/ALG therapy for severe aplastic anemia is effective. Serum sickness is a common complication in children with severe aplastic anemia following ATG/ALG therapy, but can be improved by methylprednisolone application.
Topics: Anemia, Aplastic; Antilymphocyte Serum; Child; Child, Preschool; Female; Humans; Infant; Male; Serum Sickness; T-Lymphocytes
PubMed: 17178040
DOI: No ID Found -
American Journal of Kidney Diseases :... Jul 1982
Topics: Animals; Antilymphocyte Serum; Cadaver; Graft Rejection; Graft Survival; Humans; Immunosuppression Therapy; Kidney Transplantation; Research; Transplantation Immunology
PubMed: 7048904
DOI: 10.1016/s0272-6386(82)80046-2