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The Journal of Pathology and... Jul 1954
Topics: Animals; Aortic Bodies; Dogs; Humans; Neoplasms; Paraganglioma, Extra-Adrenal
PubMed: 13212577
DOI: 10.1002/path.1700680130 -
Journal of Applied Physiology:... Mar 1981The effects of carbon monoxide inhalation and of consequent carboxyhemoglobinemia (HbCO) on the discharge rates of aortic body and carotid body chemoreceptor afferents...
The effects of carbon monoxide inhalation and of consequent carboxyhemoglobinemia (HbCO) on the discharge rates of aortic body and carotid body chemoreceptor afferents were investigated in 18 anesthetized cats. In 10 experiments both aortic and carotid chemoreceptor activities were monitored simultaneously. Carbon monoxide inhalation during normoxia always stimulated aortic chemoreceptors before carotid chemoreceptors, and the steady-state response of aortic chemoreceptors to HbCO was greater than that of most carotid chemoreceptors. Only 2 of the 18 carotid chemoreceptor fibers tested showed a distinct increase in activity in response to moderate increases in HbCO%. Thus, oxyhemoglobin contributed substantially to maintain tissue PO2 of all aortic chemoreceptors and of a few carotid chemoreceptors. Hyperoxia diminished the response of both aortic and carotid chemoreceptors to HbCO, indicating a lowered tissue PO2 as the stimulus source. We hypothesize that the aortic bodies have a much lower perfusion relative to their O2 utilization compared to the carotid bodies. As a consequence, the aortic chemoreceptors are able to act as a sensitive monitor of O2 delivery and to generate a circulatory chemoreflex for O2 homeostasis. carotid chemoreceptors monitor O2 tension and initiate strong reflex effects on the level of ventilation.
Topics: Animals; Aortic Bodies; Blood Pressure; Carbon Monoxide; Carboxyhemoglobin; Carotid Body; Cats; Chemoreceptor Cells; Hemoglobins; Oxygen Consumption; Paraganglia, Nonchromaffin; Respiration
PubMed: 7251448
DOI: 10.1152/jappl.1981.50.3.580 -
Journal of the American Animal Hospital... 2010A 10-year-old, neutered male English bulldog died acutely from respiratory distress after a short history of progressive dyspnea. Less than 2 months later, a spayed...
A 10-year-old, neutered male English bulldog died acutely from respiratory distress after a short history of progressive dyspnea. Less than 2 months later, a spayed female full sibling of that dog died suddenly during a nail trim. An aortic body tumor was the cause of death in both dogs based on postmortem and histological examinations. A pheochromocytoma was also diagnosed in the neutered male. Neither dog had a history of brachycephalic airway syndrome, and the implication for a genetic predisposition toward the development of paraganglioma is discussed. This is the first case report of aortic body tumors in sibling dogs, although the condition may not be an uncommon phenomenon.
Topics: Animals; Aortic Bodies; Breeding; Dog Diseases; Dogs; Dyspnea; Fatal Outcome; Female; Male; Nervous System Neoplasms
PubMed: 20810559
DOI: 10.5326/0460366 -
The Journal of Pathology Jun 1979The histologic features of aortic body neoplasia, hyperplasia, and normal aortico-pulmonary paraganglia were described for a series of 56 rats of several strains....
The histologic features of aortic body neoplasia, hyperplasia, and normal aortico-pulmonary paraganglia were described for a series of 56 rats of several strains. Argyrophilic cytoplasmic granules were demonstrated in chief cells of the aortic body lesions, and electron microscopic examination disclosed the presence of electron-dense, membrane-bound granules in these cells. In a series of ageing rats, hyperplasia and neoplasia of the aortico-pulmonary paraganglia occurred more frequently in female WAG/Rij rats than in males of that strain, and more frequently than in males and females of the BN/Bi strain or of the (WAG X BN)F1 hybrid. No apparent causal relationship to chronic hypoxia could be shown, in that no correlation between the development of aortic body neoplasia or hyperplasia and cardiopulmonary disease was found. Aortic body lesions did not appear to occur as part of a multiple endocrinopathy syndrome, although hyperplasia and neoplasia of various endocrine organs occurred relatively frequently in the WAG/Rij strain.
Topics: Aging; Animals; Aortic Bodies; Endocrine System Diseases; Endomyocardial Fibrosis; Female; Histocytochemistry; Hyperplasia; Lung Diseases; Male; Neoplasms; Nervous System Diseases; Paraganglia, Nonchromaffin; Paraganglioma; Rats
PubMed: 469658
DOI: 10.1002/path.1711280208 -
Acta Anatomica 1978In the buffalo, the left aortic nerve ramifies in the periarterial connective tissue between the ventral surface of the aortic arch and the truncus pulmonalis. The right...
In the buffalo, the left aortic nerve ramifies in the periarterial connective tissue between the ventral surface of the aortic arch and the truncus pulmonalis. The right aortic nerve ramifies over the dorsal and right aspects of the aorta ascendens near its origin. The histograms of myelinated fibres of both left and right aortic nerve are distinctly unimodal with peak around 4-6 micron (64.2-67.8%). The left aortic body is situated in the periarterial connective tissue between the ventral surface of the aortic arch and the truncus pulmonalis, while the right aortic body is located in the tunica adventitia of the dorsal and right aspects of the aorta ascendens near its origin. The greatest sagittal section area of the left aortic body is 0.102 +/- 0.009 mm2 and that of the right aortic body is 0.041 +/- 0.002 mm2. The organ is highly vascular. The mean size of the glomus cells from the left aortic body is 7.68 +/- 0.9 micron x 9.37 +/- 0.13 micron (short diameter x long diameter), whereas the corresponding value for the right aortic body is 7.84 +/- 0.14 micron x 9.86 +/- 0.21 micron; and their density values are (11,417 +/- 301.7)/mm2 and (9,839 +/- 213.3)/mm2 respectively.
Topics: Animals; Aorta; Aortic Bodies; Buffaloes; Male; Nerve Fibers, Myelinated; Paraganglia, Nonchromaffin
PubMed: 645340
DOI: 10.1159/000144956 -
The Canadian Veterinary Journal = La... Jan 1981
Topics: Animals; Aortic Bodies; Cattle; Cattle Diseases; Paraganglia, Nonchromaffin; Paraganglioma, Extra-Adrenal
PubMed: 6265052
DOI: No ID Found -
Australian Veterinary Journal Feb 1983
Topics: Adenoma; Animals; Aortic Bodies; Female; Horse Diseases; Horses; Paraganglia, Nonchromaffin; Paraganglioma, Extra-Adrenal
PubMed: 6301417
DOI: 10.1111/j.1751-0813.1983.tb05866.x -
Veterinary Pathology 1974
Topics: Animals; Animals, Zoo; Aortic Bodies; Bird Diseases; Ducks; Male; Paraganglia, Nonchromaffin; Paraganglioma, Extra-Adrenal; Pericardial Effusion
PubMed: 4375332
DOI: 10.1177/030098587401100203 -
Asian Journal of Surgery Feb 2023
Topics: Humans; Constriction, Pathologic; Aortic Valve Stenosis; Respiratory System; Foreign Bodies
PubMed: 35850897
DOI: 10.1016/j.asjsur.2022.07.038 -
Respiration Physiology Nov 1991Carotid body chemosensory response to hypoxia is attenuated as a result of prolonged normobaric hyperoxia (NH) in the cat. The effect of NH is likely to be due to high...
Carotid body chemosensory response to hypoxia is attenuated as a result of prolonged normobaric hyperoxia (NH) in the cat. The effect of NH is likely to be due to high cellular PO2 and O2-related free radicals. Accordingly, the effect would be less if O2 delivery to the chemoreceptor tissue could be compromised. The aortic bodies, which appear to have less of a circulatory O2 delivery, as suggested by their vigorous responses to a slight compromise of O2 flow compared with those of the carotid body, could provide a suitable testing material for the hypothesis. We tested the hypothesis by studying both aortic and carotid body chemoreceptors in the same cats (n = 6) which were exposed to nearly 100% O2 for about 60 h. These chemoreceptor organs were also studied in 6 control cats which were maintained in room air at sea-level. The cats were anesthetized and their carotid and aortic chemosensory fibers were identified by the usual procedure, and their responses to hypoxia and hypercapnia and to bolus injections (i.v.) of cyanide and nicotine were measured. In the NH cats, the carotid but not aortic chemosensory responses to hypoxia and cyanide were attenuated and to hypercapnia (both onset and steady state) augmented. The aortic chemoreceptors were stimulated by hypoxia, hypercapnia, cyanide and nicotine both in the NH and the control cats similarly. The results support the hypothesis that it is presumably a higher tissue blood flow and hence a higher concentration of O2-related free radicals which ultimately led to the specific attenuation of O2 chemoreception in the carotid body.
Topics: Analysis of Variance; Animals; Aorta; Carbon Dioxide; Carotid Body; Cats; Chemoreceptor Cells; Cyanides; Female; Hypercapnia; Hypoxia; Male; Nicotine; Oxygen
PubMed: 1780602
DOI: 10.1016/0034-5687(91)90083-u