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Thorax Jul 1969Tumours of the aortic body in man are relatively rare and were first described in 1950. Aortic bodies are found in the region of the base of the heart and great vessels,...
Tumours of the aortic body in man are relatively rare and were first described in 1950. Aortic bodies are found in the region of the base of the heart and great vessels, are thought to be of neuroepithelial origin, and have a role in maintenance of circulatory homoeostasis. A clinical report is presented of a benign aortic body tumour which was removed surgically from a 61-year-old woman.
Topics: Aortic Diseases; Female; Humans; Middle Aged; Neoplasms; Paraganglioma, Extra-Adrenal; Radiography
PubMed: 4307611
DOI: 10.1136/thx.24.4.488 -
The Journal of Veterinary Medical... Sep 2009A case of multiple primary tumors observed in the heart base and in the lung of a 7-year-old intact female, flat-coated retriever was reported. Morphological differences...
A case of multiple primary tumors observed in the heart base and in the lung of a 7-year-old intact female, flat-coated retriever was reported. Morphological differences between both tumors and detailed immunohistochemical study revealed that the cardiac neoplasm was as a malignant aortic body tumor and the lung tumor was a pulmonary histiocytic sarcoma. The occurrence of aortic body tumor with other primary neoplasms has been previously reported in animals suggesting that this might be a common presentation in dogs.
Topics: Animals; Aortic Bodies; Dog Diseases; Dogs; Female; Heart Neoplasms; Histiocytic Sarcoma; Lung Neoplasms
PubMed: 19801903
DOI: 10.1292/jvms.71.1221 -
Journal of Comparative Pathology Mar 1986A 12-year-old neutered male Husky dog had a neoplasm at the base of the heart which did not invade surrounding tissues. Microscopically, the neoplasm was composed of...
A 12-year-old neutered male Husky dog had a neoplasm at the base of the heart which did not invade surrounding tissues. Microscopically, the neoplasm was composed of nests and sheets of polyhedral cells subdivided into lobules by trabeculae of fine fibrovascular stroma. Adjacent to the neoplasm was a rim of ectopic thyroid tissue that appeared histologically normal. The possible differential diagnoses for the neoplasm were aortic body tumour, ectopic thyroid tumour and ectopic parathyroid tumour; the ultrastructural characteristics revealed it to be an aortic body tumour.
Topics: Animals; Choristoma; Dog Diseases; Dogs; Heart Neoplasms; Male; Paraganglioma, Extra-Adrenal; Thyroid Gland
PubMed: 3009566
DOI: 10.1016/0021-9975(86)90015-0 -
Journal of Comparative Pathology 2013In order to verify the malignant potential of aortic body tumours (ABTs) in dogs, 13 cases of canine ABT were studied histopathologically and immunohistochemically. The...
In order to verify the malignant potential of aortic body tumours (ABTs) in dogs, 13 cases of canine ABT were studied histopathologically and immunohistochemically. The cases were divided into two groups according to the presence or absence of metastases to other organs at necropsy examination (metastasis group [n = 9] and non-metastasis group [n = 4]). The mean tumour weight:body weight ratio (TW:BW; g/kg) in the metastasis group (9.3 ± 6.7) was significantly higher than that in the non-metastasis group (1.5 ± 1.7) (P <0.05). In both groups, the neoplastic cells had malignant features including pleomorphism, anisocytosis and anisokaryosis, and mononuclear giant cells were present, showing invasion through the capsule and into the vascular lumen and other adjacent tissues. The mitotic index (MI), mean nuclear area (NA) for size value and coefficient of variation of the nuclear area (CVNA) for anisonucleosis did not differ significantly between the two groups. These findings show that anaplastic characteristics are present regardless of the tumour size or the presence or absence of metastases, suggesting that these tumours are generally malignant or potentially malignant. Immunohistochemical analysis using neuroendocrine markers including neuron-specific enolase, chromogranin A and S100 revealed no obvious differences in labelling intensity of neoplastic cells related to the presence or absence of metastases or associated with the mean TW:BW, MI, NA or CVNA value, indicating that immunohistochemistry has no practical value for determining the tumour grade of canine ABTs.
Topics: Animals; Aortic Bodies; Biomarkers, Tumor; Dog Diseases; Dogs; Immunohistochemistry; Paraganglioma, Extra-Adrenal
PubMed: 23465289
DOI: 10.1016/j.jcpa.2012.12.007 -
Veterinary Surgery : VS 2002To evaluate the effect of perioperative and operative variables on survival time in dogs with aortic body tumors.
OBJECTIVE
To evaluate the effect of perioperative and operative variables on survival time in dogs with aortic body tumors.
STUDY DESIGN
Retrospective study.
SAMPLE POPULATION
Twenty-four client-owned dogs with histologically confirmed aortic body tumor.
METHODS
Seventy-eight patient records of dogs seen at the University of Illinois Veterinary Teaching Hospital between 1989 and 1999 with a diagnosis of a heart-base mass were reviewed. Dogs without histologic conformation of an aortic body tumor were excluded. Age; sex; breed; the presence of pleural effusion, pericardial effusion, or abdominal effusion; evidence of cardiac arrhythmias; evidence of distant metastasis; treatment with pericardectomy; treatment with chemotherapy; and time from diagnosis until euthanasia or death were recorded on a spreadsheet. Cox proportional-hazard ratios were used to calculate the relationship of risk variables to survival time. Median survival time was determined using life-table analysis.
RESULTS
Twenty-four dogs met the criteria for inclusion in the study. The median age of dogs with aortic body tumors was 9 years. All dogs had a surgical biopsy performed. Fourteen dogs had a pericardectomy at the time of the biopsy procedure. Of all factors analyzed, only treatment with pericardectomy had a significant influence on survival (P =.0029). Dogs that had pericardectomy survived longer (median survival, 730 days; range, 1-1,621 days) compared with dogs that did not have pericardectomy (median survival, 42 days; range, 1-180 days). This finding was independent of the presence or absence of pericardial effusion at the time of surgery.
CLINICAL RELEVANCE
Dogs that are diagnosed with aortic body tumors may benefit from a pericardectomy at the time of surgical biopsy.
Topics: Animals; Aorta; Breeding; Dog Diseases; Dogs; Female; Hemangiosarcoma; Male; Pericardiectomy; Records; Retrospective Studies; Risk Factors; Survival Analysis; Vascular Neoplasms
PubMed: 11778166
DOI: 10.1053/jvet.2002.29989 -
The Journal of Physiology Jun 19981. The reflex changes in the inotropic state of the left ventricle, measured as the dP/dt max (maximum rate of change of pressure), occurring in response to selective...
1. The reflex changes in the inotropic state of the left ventricle, measured as the dP/dt max (maximum rate of change of pressure), occurring in response to selective stimulation of the carotid and aortic body chemoreceptors by sodium cyanide, were studied in the cat anaesthetized with a mixture of chloralose and urethane. 2. The animals were artificially ventilated with an open pneumothorax. The heart rate and mean arterial blood pressure were maintained constant. 3. With on-going central respiratory activity, stimulation of the carotid bodies caused an increase in respiratory movements. Variable changes in left ventricular dP/dt max occurred, the predominant response being an increase. The mean change was 8.3 +/- 2.9 % from a control value of 6850 +/- 450 mmHg s-1. Stimulation of the aortic bodies resulted in a smaller increase in respiration or no effect, but a significant increase occurred in left ventricular dP/dt max of 19.6 +/- 2.9 % from a control value of 6136 +/- 228 mmHg s-1. No significant changes in left ventricular end-diastolic pressure occurred in response to stimulation of either group of chemoreceptors. 4. Tests of chemoreceptor stimulations were repeated during temporary suppression of the secondary respiratory mechanisms: the central respiratory drive was suppressed reflexly by electrical stimulation of the central cut ends of both superior laryngeal nerves and lung stretch afferent activity was minimized by stopping artificial respiration. Carotid body stimulation again evoked variable responses, the predominant now being a reduction in left ventricular dP/dt max of 3.1 % from a control value of 5720 +/- 320 mmHg s-1, which was significantly different to that occurring during on-going spontaneous respiration. Aortic body stimulation caused an increase in left ventricular dP/dt max similar to the response during on-going spontaneous respiration. 5. The positive inotropic responses were mediated via the sympathetic nervous system, as indicated by their abolition as a result of intravenous injections of the beta-adrenoceptor blocking agent, propranolol. 6. It is concluded that the carotid bodies exert a small variable effect on left ventricular dP/dt max, the predominant positive inotropic response being due to the concomitant neurogenic effects of the increase in respiration. In contrast, the positive inotropic response to excitation of the aortic chemoreceptors is not respiratory modulated.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Afferent Pathways; Animals; Aortic Bodies; Apnea; Carotid Body; Cats; Efferent Pathways; Enzyme Inhibitors; Female; Heart; Isoproterenol; Male; Propranolol; Reflex; Respiration; Sodium Cyanide; Ventricular Function, Left
PubMed: 9596808
DOI: 10.1111/j.1469-7793.1998.895bm.x -
Circulation Research Jan 1980We stimulated the aortic chemoreceptors in dogs that were anesthetized with chloralose and artificially ventilated by perfusing the isolated aortic arch with venous...
We stimulated the aortic chemoreceptors in dogs that were anesthetized with chloralose and artificially ventilated by perfusing the isolated aortic arch with venous blood. Inotropic responses were determined by measuring the maximum rate of change of left ventricular pressure (dP/dt max) with aortic pressure and heart rate held constant. Stimulation of the aortic chemoreceptors resulted in an average increase in heart rate of 14 +/- 2.0 beats/min (mean +/- SE) from 166 +/- 7.7 beats/min and an increase in dP/dt max of 501 +/- 85 mm Hg/sec from 3508 +/- 154 mm Hg/sec. These changes were statistically significant (P less than 0.001). The afferent pathway of the reflex was shown to be in the vagus nerves and the efferent pathway in the cardiac sympathetic nerves. In some of the dogs, the carotid chemoreceptors were also stimulated. This resulted in decreases in heart rate and dP/dt max of 48 +/- 24 beats/min and 795 +/- 142 mm Hg/sec. Thus we have shown that stimulation of aortic chemoreceptors evokes chronotropic and inotropic responses opposite to those evoked from stimulation of carotid chemoreceptors.
Topics: Animals; Aorta, Thoracic; Aortic Bodies; Blood Pressure; Carbon Dioxide; Carotid Arteries; Chemoreceptor Cells; Dogs; Heart; Heart Rate; Hemodynamics; Hydrogen-Ion Concentration; Oxygen; Paraganglia, Nonchromaffin; Perfusion; Sympathetic Nervous System; Vagotomy; Veins
PubMed: 7349920
DOI: 10.1161/01.res.46.1.77 -
Current Problems in Diagnostic Radiology 2020Paragangliomas are extra-adrenal tumors that are derived from neuroendocrine chromaffin cells. The rare disease has a variable presentation depending upon its anatomic...
Paragangliomas are extra-adrenal tumors that are derived from neuroendocrine chromaffin cells. The rare disease has a variable presentation depending upon its anatomic location and functionality. We describe the case of a 56-year-old female patient who had an incidental mass found on imaging. The patient underwent biochemical testing and a mediastinal biopsy due to the nonspecific imaging findings. The mediastinal mass was resected through hemisternotomy and found to be a functional paraganglioma. This case highlights the importance of radiologists to consider the prospect of paragangliomas in the differential diagnosis of an intra-thoracic mass.
Topics: Aortic Bodies; Biopsy; Contrast Media; Diagnosis, Differential; Female; Humans; Mediastinal Neoplasms; Middle Aged; Paraganglioma; Thoracoscopy; Tomography, X-Ray Computed
PubMed: 30316617
DOI: 10.1067/j.cpradiol.2018.08.011 -
Cirugia Espanola Oct 2016
Review
Topics: Adult; Humans; Male; Para-Aortic Bodies; Paraganglioma
PubMed: 27166450
DOI: 10.1016/j.ciresp.2016.04.002 -
Veterinary Pathology Mar 1980
Topics: Animals; Aortic Bodies; Bone Neoplasms; Dog Diseases; Dogs; Ilium; Male; Paraganglia, Nonchromaffin; Paraganglioma, Extra-Adrenal
PubMed: 6244689
DOI: 10.1177/030098588001700214