-
BMJ Case Reports Oct 2019
Topics: Anemia, Aplastic; Female; Humans; Retinal Diseases; Tomography, Optical Coherence; Vision, Low; Young Adult
PubMed: 31615780
DOI: 10.1136/bcr-2019-232426 -
Lancet (London, England) Oct 1977
Topics: Anemia, Aplastic; Animals; Antilymphocyte Serum; Bone Marrow Transplantation; Hematopoietic Stem Cells; Humans; Mice; Transplantation, Homologous
PubMed: 71548
DOI: No ID Found -
British Journal of Haematology Jan 1972
Review
Topics: Adrenal Cortex Hormones; Adult; Androgens; Anemia, Aplastic; Bone Marrow Transplantation; Humans; Lectins; Leukopenia; Models, Biological; Splenectomy; Thrombocytopenia; Transplantation, Homologous
PubMed: 4551154
DOI: 10.1111/j.1365-2141.1972.tb08781.x -
International Journal of Hematology Aug 2002Aplastic anaemia seems to be predominantly a defect of the stem cell rather than the stroma, though abnormalities of the microenvironment may co-exist. There is highly... (Review)
Review
Aplastic anaemia seems to be predominantly a defect of the stem cell rather than the stroma, though abnormalities of the microenvironment may co-exist. There is highly suggestive evidence that the stem cell is the target of an immune attack, though the main evidence remains the response to immunosuppression with antilymphocyte globulin and cyclosporin. The stem cell defect remains even after recovery of the peripheral blood counts and the AA marrow is a fertile environment for the emergence of abnormal clones, particularly PNH. However, it has recently become apparent that there is an overlap with the myelodysplastic syndromes and clones of monosomy 7 and trisomy 8 amongst others are not uncommon in aplastic anaemia. Recent work has suggested that the emergence of a clone of monosomy 7 cells carries a poor prognosis, whereas trisomy 8 has a good prognosis particularly in response to cyclosporin. However, the setting in which monosomy 7 arises may affect the phenotypic expression. The immune targeting of stem cells may be associated with increased apoptosis in aplastic anaemia, in part mediated by fas expression, but not exclusively. Understanding the pathophysiology of AA should help to improve and perhaps target therapy.
Topics: Anemia, Aplastic; Clone Cells; Hematopoietic Stem Cells; Humans; Immunosuppressive Agents
PubMed: 12430919
DOI: 10.1007/BF03165109 -
Leukemia Nov 2016
Topics: Anemia, Aplastic; Humans; Myelodysplastic Syndromes; Probability; Uncertainty
PubMed: 27585953
DOI: 10.1038/leu.2016.206 -
Lancet (London, England) Nov 2011
Comparative Study Review
Topics: Anemia, Aplastic; Animals; Antilymphocyte Serum; Cyclosporine; Humans; Immunosuppressive Agents; Prognosis; Rabbits; Randomized Controlled Trials as Topic; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Survival Analysis; Treatment Outcome
PubMed: 21737135
DOI: 10.1016/S0140-6736(11)60817-9 -
Zhonghua Xue Ye Xue Za Zhi = Zhonghua... Apr 1998
Topics: Anemia, Aplastic; Humans
PubMed: 11243127
DOI: No ID Found -
The Medical Journal of Australia Jul 1986
Topics: Aged; Anemia, Aplastic; Humans; Male; Naproxen
PubMed: 3724632
DOI: 10.5694/j.1326-5377.1986.tb113749.x -
Acta Haematologica 1991
Review
Topics: Anemia, Aplastic; Bone Marrow; Hematopoiesis; Humans
PubMed: 1950373
DOI: 10.1159/000204805 -
The Journal of Infection Sep 1989Haematological changes associated with infectious disease are relatively common but true aplastic anaemia secondary to infection is rare. We describe a patient wit... (Review)
Review
Haematological changes associated with infectious disease are relatively common but true aplastic anaemia secondary to infection is rare. We describe a patient wit disseminated Mycobacterium avium-intracellulare infection and who had a histologically proven remission of his aplastic anemia accompanying antimycobacterial therapy. We also review the literature on the haematological changes associated with mycobacterial infections and other infectious causes of aplastic anaemia.
Topics: Aged; Anemia, Aplastic; Bone Marrow; Humans; Leukocyte Count; Lymph Nodes; Male; Mycobacterium avium Complex; Mycobacterium avium-intracellulare Infection; Platelet Count
PubMed: 2681429
DOI: 10.1016/s0163-4453(89)91964-6