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Journal of Cutaneous Pathology Dec 2023Primary cutaneous apocrine carcinoma is a rare adnexal tumor that arises from apocrine progenitor cells. These tumors may be associated with benign apocrine hyperplasia,...
Primary cutaneous apocrine carcinoma is a rare adnexal tumor that arises from apocrine progenitor cells. These tumors may be associated with benign apocrine hyperplasia, and a longstanding history of a lesion should not preclude a malignant diagnosis. We report a case of a 70-year-old female who presented to the clinic with a 3-year history of an asymptomatic vulvar lesion. An excisional biopsy was performed. Histopathologic examination revealed a tumor with two distinct components. The first component was determined to be a benign tubular apocrine adenoma. The second component, arising within the apocrine adenoma, was determined to be an apocrine carcinoma based on histopathologic features and immunohistochemical profile. Twelve months after subsequent wide local excision and sentinel node biopsy, the patient is alive without recurrence.
Topics: Female; Humans; Aged; Apocrine Glands; Diagnosis, Differential; Sweat Gland Neoplasms; Adenoma; Sentinel Lymph Node Biopsy; Carcinoma
PubMed: 37718479
DOI: 10.1111/cup.14509 -
Medicine Dec 2021Tubular apocrine adenoma (TAA) is a very rare benign neoplasm of the apocrine gland. The typical anatomical locations are mostly hair-bearing areas, where normal...
RATIONALE
Tubular apocrine adenoma (TAA) is a very rare benign neoplasm of the apocrine gland. The typical anatomical locations are mostly hair-bearing areas, where normal apocrine glands are abundant.
PATIENT CONCERNS
We report the case of a 40-year-old patient with a tubular apocrine adenoma on a non-hair-bearing area.
DIAGNOSES
Ultrasonography showed a 0.4-cm-sized hypoechoic nodule in the subcutaneous plane of the left palm at the fourth carpometacarpal joint level.
INTERVENTIONS
Surgical resection was performed and histopathological examination revealed lobules of well-differentiated dilated tubular structures at the dermis level.
OUTCOMES
At 1 year of postoperative follow-up, the patient was completely recovered without signs of recurrence.
LESSONS
Diagnosis of TAA can be misleading due to its unusual location and inconspicuous appearance. Immunohistochemistry for epithelial membrane antigen and gross cystic disease fluid protein-15 is crucial for the proper diagnosis. Complete excision is recommended to prevent recurrence.
Topics: Adult; Apocrine Glands; Epithelial Cells; Humans; Sweat Gland Neoplasms; Tubular Sweat Gland Adenomas
PubMed: 34889245
DOI: 10.1097/MD.0000000000028002 -
The Journal of Dermatology Jan 2019
Topics: Adenoma, Sweat Gland; Adult; Apocrine Glands; Biomarkers, Tumor; Female; Foot; Humans; Sweat Gland Neoplasms
PubMed: 29863779
DOI: 10.1111/1346-8138.14494 -
The West Virginia Medical Journal 2008A case of apocrine adenoma, a rare benign tumor of the breast is reported. A left breast nodule from a 47-year-old female was found by mammography and excised. The tumor...
A case of apocrine adenoma, a rare benign tumor of the breast is reported. A left breast nodule from a 47-year-old female was found by mammography and excised. The tumor was well circumscribed and composed of tightly packed tubules lined by cells with apocrine features. There has been no recurrence in two years. The few previously reported cases are summarized. Apocrine adenomas have been reported arising in a variety of sites including the breast, (1-5) perianal region, (6,7) eyelid, (8) and axilla. (9) Their appearance has similarities to the apocrine metaplasia commonly seen in fibrocystic change of the breast but they are well-circumscribed tumors with closely packed tubular and papillary structures. They are not distinctive by mammography or physical examination and should be managed as any other breast mass.
Topics: Adenoma, Sweat Gland; Apocrine Glands; Biopsy, Needle; Breast Neoplasms; Diagnosis, Differential; Female; Humans; Mammography; Middle Aged; Ultrasonography, Mammary
PubMed: 18491794
DOI: No ID Found -
Human Pathology Mar 2018Tubular apocrine adenoma (TAA) and papillary eccrine adenoma (PEA) are benign sweat gland tumors. Their names imply that they exhibit apocrine and eccrine...
Tubular apocrine adenoma (TAA) and papillary eccrine adenoma (PEA) are benign sweat gland tumors. Their names imply that they exhibit apocrine and eccrine differentiation, respectively. However, morphologically they are very similar and are often indistinguishable. The molecular pathogenesis of either tumor is poorly understood at present. On the basis of an index case of nipple adenoma that was morphologically reminiscent of cutaneous TAA/PEA and harbored a BRAF mutation, we investigated whether a similar genetic change is also present in TAA/PEA. BRAF, RAS, and PIK3CA mutation analyses, and BRAF-specific immunohistochemistry were performed for 24 TAAs/PEAs, 10 eccrine poromas, 7 apocrine cystadenomas, 2 TAA-like adenomas associated with nevus sebaceus, and one apocrine adenoma probably arising in anogenital mammary-like glands (AGMLGs). The results demonstrated that BRAF mutations were present in TAAs (9/15, 60%) and PEAs (7/9, 78%), but not in other neoplasms. Two additional TAAs harbored KRAS mutations. In addition, a KRAS mutation was identified in one nevus sebaceus-associated TAA-like adenoma. The speculated AGMLG-related apocrine adenoma had a PIK3CA mutation. We concluded that activating BRAF and KRAS mutations were commonly present in TAAs/PEAs, indicating that in addition to a morphological resemblance, they are closely related genetically. Therefore, they could be considered to be united as a single entity. By contrast, the apocrine adenoma probably arising in AGMLG harbored a PIK3CA mutation, which is also commonly present in hidradenoma papilliferum. Further studies are necessary to determine whether the pathogenesis of AGMLG-related tumors is similar to breast tumors.
Topics: Adenoma; Adult; Aged; Aged, 80 and over; Apocrine Glands; DNA Mutational Analysis; Female; Humans; Male; Middle Aged; Mutation; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); Sweat Gland Neoplasms
PubMed: 29241739
DOI: 10.1016/j.humpath.2017.12.002 -
Head & Neck Sep 2023In this systematic review, we aimed to evaluate the clinicopathological profile of sclerosing polycystic adenoma (SPA). PubMed, Scopus, EMBASE, Lilacs, Web of Science,... (Review)
Review
In this systematic review, we aimed to evaluate the clinicopathological profile of sclerosing polycystic adenoma (SPA). PubMed, Scopus, EMBASE, Lilacs, Web of Science, and gray literature were searched to access cases of SPA in salivary glands. One hundred and thirty cases of SPA were found across 61 selected articles. SPA affected mainly the parotid gland of adults with a mean age of 44.6 years old, with a slight preference for females. The lesion was usually presented as a painless firm mass with a long period of evolution. Histologically, they are well-delimitated lesions composed of acinar and ductal elements with a variety of cytomorphologic features surrounded by a densely collagenized stroma. PI3K was the most common gene mutation related to SPA. SPA is a benign condition that mainly affects the parotid gland of female patients and it is usually treated by surgical resection with a good prognosis.
Topics: Adult; Humans; Female; Parotid Gland; Adenoma; Sclerosis
PubMed: 37403748
DOI: 10.1002/hed.27435 -
Archives of Pathology & Laboratory... Nov 2003We describe a rare case of apocrine adenoma of the breast in a 45-year-old man. The patient presented with a tender lump in his left breast that had been present for 6... (Review)
Review
We describe a rare case of apocrine adenoma of the breast in a 45-year-old man. The patient presented with a tender lump in his left breast that had been present for 6 months. A mammogram identified a 3-mm nodular density in the breast, which was described as a hypoechoic nodule on ultrasound. Microscopic examination of tissue from an excisional biopsy revealed a 3-mm group of benign glands with abundant granular, eosinophilic cytoplasm and apical luminal blebbing, consistent with an apocrine adenoma. After reviewing other reported apocrine adenomas in the literature, we determined that our case was the smallest detected apocrine adenoma to be reported to date.
Topics: Adenoma, Sweat Gland; Apocrine Glands; Breast Neoplasms, Male; Humans; Male; Middle Aged; Sweat Gland Neoplasms
PubMed: 14567753
DOI: 10.5858/2003-127-1498-TAAIAM -
The American Journal of Dermatopathology Nov 2017Syringocystadenoma papilliferum (SCAP), apocrine gland cyst (AGC, also called apocrine hidrocystoma or apocrine cystadenoma), and tubular papillary adenoma (TPA) with...
Syringocystadenoma papilliferum (SCAP), apocrine gland cyst (AGC, also called apocrine hidrocystoma or apocrine cystadenoma), and tubular papillary adenoma (TPA) with apocrine differentiation are defined as proliferations of apocrine epithelium with myoepithelial cells. At Sapporo Dermatopathology Institute, we retrieved 308 benign neoplastic lesions diagnosed as SCAP, AGC, or TPA and combinations of these entities. Among the 308 lesions, 202 (66%) exhibited features of only one type, of which 144 (47%) were AGC, 39 (13%) were TPA, and 19 (6%) were SCAP. The other 106 lesions (34%) had features of 2 or more types, including 56 lesions that were AGC + TPA (18%), 2 that were AGC + SCAP (1%), 34 that were TPA + SCAP (11%), and 14 that were AGC + TPA + SCAP (5%). The most frequent site of these lesions was the face (56%), followed by the scalp (13%). Lesions with the features of AGC were more frequently found on the face, especially the periocular region, than at other sites. TPA lesions were more frequent on the face and scalp than at other sites, whereas SCAP lesions were preferentially found on the face, scalp, and trunk. We also retrieved clinicopathological data and other information. We propose a unifying concept for AGC, TPA, and SCAP. Approximately one-third of these lesions are composite entities with the features of 2 or 3 different tumors, and we propose calling such tumors tubulopapillary cystic adenoma with apocrine differentiation.
Topics: Acrospiroma; Adenoma; Adult; Aged; Apocrine Glands; Biopsy; Cell Differentiation; Facial Neoplasms; Female; Humans; Japan; Male; Middle Aged; Neoplasms, Complex and Mixed; Scalp; Sweat Gland Neoplasms; Terminology as Topic; Tubular Sweat Gland Adenomas; Young Adult
PubMed: 28033156
DOI: 10.1097/DAD.0000000000000814 -
Ear, Nose, & Throat Journal Nov 2023Apocrine hidrocystoma is a cystic tumor originating from apocrine sweat glands. It is predominantly located in the eyelid margins. Here, we report a case of apocrine...
Apocrine hidrocystoma is a cystic tumor originating from apocrine sweat glands. It is predominantly located in the eyelid margins. Here, we report a case of apocrine hidrocystoma of the parotid gland in a 19-year-old man who was referred to our outpatient clinic with a 5-year history of a gradual swelling in the left parotid region. The patient underwent left superficial parotidectomy. Histological examination confirmed the diagnosis of apocrine hidrocystoma. The case is original by the tumor's location: to the best of our knowledge, this could be the first case in English and French literature reporting an apocrine hidrocystoma affecting the parotid gland. The purpose of this article is to report our case and discuss its clinical and anatomopathological features as well as its differential diagnoses.
Topics: Male; Humans; Young Adult; Adult; Hidrocystoma; Parotid Gland; Sweat Gland Neoplasms; Eyelids; Diagnosis, Differential
PubMed: 34219505
DOI: 10.1177/01455613211031028 -
International Journal of Dermatology Nov 2019
Topics: Adenoma; Dermoscopy; Diagnosis, Differential; Head and Neck Neoplasms; Humans; Male; Microscopy, Confocal; Middle Aged; Scalp; Sweat Gland Neoplasms; Sweat Glands
PubMed: 31286506
DOI: 10.1111/ijd.14579