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Pathology May 2001Apocrine adenoma is a rare benign epithelial tumour of the breast that can radiologically present as a well-defined opacity. The clinical, radiological and pathological...
Apocrine adenoma is a rare benign epithelial tumour of the breast that can radiologically present as a well-defined opacity. The clinical, radiological and pathological findings of apocrine adenoma of the breast in a 72-year-old woman are described. Histologically, the tumour is characterised by a circumscribed proliferation of metaplastic apocrine cells which may contain calcifications. Pathological assessment of the lesion is essential in making the diagnosis.
Topics: Adenoma; Aged; Apocrine Glands; Biopsy, Needle; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Humans; Mammography; Microscopy, Electron; Microvilli; Mitochondria; Neoplasms, Second Primary; Ultrasonography
PubMed: 11358045
DOI: No ID Found -
Dermatologic Clinics Oct 2018Cutaneous adnexal tumors include lesions with apocrine, eccrine, follicular, sebaceous, and mixed differentiation. Most are benign and sporadic, although malignant forms... (Review)
Review
Cutaneous adnexal tumors include lesions with apocrine, eccrine, follicular, sebaceous, and mixed differentiation. Most are benign and sporadic, although malignant forms are occasionally observed and some cases develop in the setting of inherited syndromes. These tumors often cause immense diagnostic difficulty. Dermoscopy is a noninvasive technique that has greatly improved the diagnostic accuracy of different skin lesions, including these tumors. We provide a review of the literature on the dermoscopic structures and patterns associated with adnexal tumors. Most patterns associated with this kind of tumor are nonspecific and are observed in other nonadnexal tumors, especially in basal cell carcinomas.
Topics: Acrospiroma; Adenoma; Birt-Hogg-Dube Syndrome; Carcinoma; Carcinoma, Adenoid Cystic; Dermoscopy; Follicular Cyst; Hair Diseases; Hidrocystoma; Humans; Hyperplasia; Neoplasms, Basal Cell; Neoplastic Syndromes, Hereditary; Nevus, Sebaceous of Jadassohn; Pilomatrixoma; Poroma; Sebaceous Gland Neoplasms; Sebaceous Glands; Skin Neoplasms; Sweat Gland Neoplasms; Syringoma; Tubular Sweat Gland Adenomas
PubMed: 30201149
DOI: 10.1016/j.det.2018.05.007 -
Journal of Cutaneous Pathology Oct 1984
Review
Topics: Adenocarcinoma; Adenoma; Adenoma, Sweat Gland; Adult; Aged; Apocrine Glands; Cystadenoma; Eyelid Neoplasms; Female; Humans; Male; Middle Aged; Sweat Gland Neoplasms; Sweat Glands
PubMed: 6096425
DOI: 10.1111/j.1600-0560.1984.tb00400.x -
Journal of the American Academy of... Apr 1980Two examples of apocrine neoplasm are presented, contrasting the features of an apocrine adenoma with those of a possible apocrine adenocarcinoma. Apocrine...
Two examples of apocrine neoplasm are presented, contrasting the features of an apocrine adenoma with those of a possible apocrine adenocarcinoma. Apocrine adenocarcinoma, distinct from Paget's disease, is a rare neoplasm. Its recognition is complicated by long periods of benign growth and by subtle histologic differences from apocrine adenoma.
Topics: Adenocarcinoma; Adenoma; Aged; Apocrine Glands; Carcinoma; Diagnosis, Differential; Female; Humans; Middle Aged; Sweat Gland Neoplasms
PubMed: 7364989
DOI: 10.1016/s0190-9622(80)80045-4 -
Eye (London, England) Feb 2005
Topics: Adenoma; Apocrine Glands; Eyelid Neoplasms; Female; Humans; Middle Aged; Sweat Gland Neoplasms
PubMed: 15105822
DOI: 10.1038/sj.eye.6701426 -
Dermatology Online Journal Feb 2003Tubular apocrine adenoma is a very rare sweat gland tumor. In this report, a case of tubular apocrine adenoma in association with syringocystadenoma papilliferum on the...
Tubular apocrine adenoma is a very rare sweat gland tumor. In this report, a case of tubular apocrine adenoma in association with syringocystadenoma papilliferum on the scalp is presented. The stroma of the tubular apocrine adenoma consisted of numerous, young fibroblasts with mitotic activity. It was difficult to distinguish stromal cells and epithelial cells from each other in some areas. The characteristics and differences in histopathologic and immunohistochemical findings in these tumors are described.
Topics: Adenoma, Sweat Gland; Adult; Apocrine Glands; Biomarkers, Tumor; Carcinoembryonic Antigen; Diagnosis, Differential; Humans; Immunohistochemistry; Keratins; Male; Neoplasms, Multiple Primary; S100 Proteins; Scalp; Sweat Gland Neoplasms
PubMed: 12639465
DOI: No ID Found -
Ophthalmic Plastic and Reconstructive...To report the characteristics and long-term outcomes of patients presenting with carcinoma ex-pleomorphic adenoma (CXPA) or malignant mixed tumor of the lacrimal gland.
AIMS
To report the characteristics and long-term outcomes of patients presenting with carcinoma ex-pleomorphic adenoma (CXPA) or malignant mixed tumor of the lacrimal gland.
METHODS
A retrospective case-note review for patients with CXPA, seen at Moorfields Eye Hospital between 1985 and 2018, was performed for demographics, presentation, imaging, histopathology, management, and outcome.
RESULTS
Twenty-six patients (11 male; 42%) presented at a mean age of 46 years (median 46.4; range 24-81), with average symptom(s) duration of 67 months (median 24 months; range 6 weeks-53 years). The commonest symptoms were proptosis (13 patients; 50%), orbital ache or pain (11/26, 42%), having noted a lump in the upper eyelid (8/26, 31%), and diplopia (7/26, 27%). About 90% of patients had nonaxial globe displacement, over a half had a palpable mass and 3-quarters had reduced motility. Adenocarcinoma was the commonest malignant component of the tumor, occurring in 16 (62%) of the patients, followed by adenoid cystic carcinoma in 5 patients (19%); 10/26 (28%) tumors showed significant invasion on histological examination. A quarter of the patients had tumor-related death at an average of 2.8 years after diagnosis (median 2.5; range 1.5-4.4 years), and the overall probability of survival for the whole cohort was 63% at both 5 years and 10 years after treatment. The prognosis for CXPA was significantly worse with a history of prior incompletely excised pleomorphic adenoma (p < 0.001), a markedly invasive malignant component (p = 0.001), evidence of perineural invasion (p = 0.042), and an American Joint Committee on Cancer tumor size of T3 or greater (p = 0.024).
CONCLUSION
Intact excision of CXPAs that do not display histological evidence of extension beyond the tumor pseudocapsule have a good outcome, similar to that for intact excision of benign pleomorphic adenomas. In contrast, our patients with markedly invasive CXPA had a tendency to local recurrence or distant metastasis, and tumor-related death occurred in about two-thirds.
Topics: Adenoma; Adenoma, Pleomorphic; Carcinoma; Humans; Lacrimal Apparatus; Male; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies
PubMed: 33710040
DOI: 10.1097/IOP.0000000000001957 -
Virchows Archiv. A, Pathological... 1980Five cases of apocrine hidrocystoma of the anal glands are described, two of which are dealt with in detail, as they were a primary cause of the patients' complaints....
Five cases of apocrine hidrocystoma of the anal glands are described, two of which are dealt with in detail, as they were a primary cause of the patients' complaints. The three additional cases were found incidentally during histologic examination of hemorrhoidectomy specimens. All five patients were women between 32 and 65 years of age. The similarities with the better known cutanous hidrocystomas of other sites harbouring apocrine sweat glands are emphasized and the morphogenesis of these lesions is considered. In addition, a rare adenoma of the apocrine anal glands in a 46 year old woman is described and the problems of diagnostic classification in examples lacking predominantly papillary structures are discussed.
Topics: Adenoma; Adenoma, Sweat Gland; Adult; Aged; Apocrine Glands; Female; Hemorrhoids; Humans; Middle Aged; Skin Diseases; Sweat Glands
PubMed: 6245497
DOI: 10.1007/BF00427235 -
Orbit (Amsterdam, Netherlands) Jun 2022Lacrimal gland pleomorphic adenomas (LGPA) are benign mixed tumors. Diagnosis is based on clinical and radiological findings which usually prompts complete excision of...
Lacrimal gland pleomorphic adenomas (LGPA) are benign mixed tumors. Diagnosis is based on clinical and radiological findings which usually prompts complete excision of the lesion to minimise recurrence and a cumulative risk of malignant transformation. Necrosis in pleomorphic adenoma has been rarely reported in salivary gland PA, either spontaneously or due to iatrogenic interventions. Necrosis is suggestive of a malignant process and makes interpretation of histology specimens difficult. A 23 year old woman, while awaiting biopsy for a mass in the left lacrimal gland, which had been symptomatic for only several months, presented with acute pain and swelling of the left lateral lid. An incisional biopsy showed an inflamed lacrimal gland with focal necrosis and atypia of adjacent cytology and gland architecture. Subsequent excisional biopsy confirmed an LGPA with some inflammation but no necrosis. Necrosis may occur as an atypical presentation in LGPA.
Topics: Adenoma, Pleomorphic; Adult; Eye Neoplasms; Female; Humans; Lacrimal Apparatus; Lacrimal Apparatus Diseases; Necrosis; Young Adult
PubMed: 33402001
DOI: 10.1080/01676830.2020.1867194 -
Journal of the American Academy of... Nov 2007Adenomas in the anogenital region are uncommon. There has been debate about the origin, including ectopic breast tissue, cutaneous apocrine gland, and most recently... (Review)
Review
Adenomas in the anogenital region are uncommon. There has been debate about the origin, including ectopic breast tissue, cutaneous apocrine gland, and most recently anogenital mammary-like gland. An anogenital mass in a 36-year-old woman was excised, and histopathologic examination and immunostaining were performed. Microscopic tissue sections showed a morphologic pattern similar to that of a mammary fibroadenoma, and immunostaining demonstrated the presence of estrogen receptors and progesterone receptors. The possibility of adenomas of anogenital mammary-like glands should be considered when evaluating patients with a mass in this area with confirmation by tissue biopsy or aspiration cytology.
Topics: Adenoma; Adult; Anus Neoplasms; Female; Genital Neoplasms, Female; Humans; Mammary Glands, Human
PubMed: 17845825
DOI: 10.1016/j.jaad.2006.04.086