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Cornea Jul 2016To compare the corneal biomechanical properties and intraocular pressure (IOP) levels in patients with and without arcus senilis (AS). (Comparative Study)
Comparative Study
PURPOSE
To compare the corneal biomechanical properties and intraocular pressure (IOP) levels in patients with and without arcus senilis (AS).
METHODS
Ocular response analyzer measurements were performed on the right eyes of 37 patients with AS (group 1) and 37 control eyes (group 2). Corneal hysteresis, corneal resistance factor, Goldmann-correlated IOP, and corneal compensated IOP were recorded with Ocular response analyzer. Spherical equivalent value of the refractive errors, axial length, central corneal thickness, and IOP measured with Goldmann applanation tonometer were noted for each study eyes. Statistical analyses were performed with Student t, Kruskal-Wallis, and Pearson correlation tests.
RESULTS
Mean age was 67.6 ± 9.8 years in group 1 and 65.3 ± 8.1 years in group 2 (P = 0.308). Mean corneal hysteresis and corneal resistance factor readings were 9.8 ± 0.9 versus 10.6 ± 0.8 (P < 0.001) and 10.05 ± 1.07 versus 10.9 ± 0.9 (P < 0.001) in groups 1 and 2, respectively. Mean corneal compensated IOP and Goldmann-correlated IOP values were found as 16.1 ± 3.3 mm Hg versus 15.8 ± 2.6 mm Hg (P = 0.719) and 15.1 ± 3.3 mm Hg versus 15.0 ± 2.6 mm Hg (P = 0.912) in groups 1 and 2, respectively. There was no statistical difference in IOP measured with Goldmann applanation tonometer, central corneal thickness, spherical equivalent value of the refractive error, axial length measurements, and mean keratometry readings between the 2 groups (P = 0.983, P = 0.289, P = 0.938, P = 0.886, P = 0.07, respectively).
CONCLUSIONS
The mean corneal hysteresis and corneal resistance factor values of eyes with AS were lower when compared with the controls. This study demonstrated that AS may change the corneal biomechanical properties.
Topics: Aged; Aged, 80 and over; Arcus Senilis; Axial Length, Eye; Biomechanical Phenomena; Cornea; Elasticity; Female; Humans; Intraocular Pressure; Male; Middle Aged; Prospective Studies; Tonometry, Ocular; Visual Acuity
PubMed: 27124777
DOI: 10.1097/ICO.0000000000000856 -
American Journal of Ophthalmology Aug 2018
Topics: Arcus Senilis; Asian People; Cardiovascular Diseases; Humans
PubMed: 29853153
DOI: 10.1016/j.ajo.2018.05.016 -
American Journal of Ophthalmology Apr 2018
Topics: Arcus Senilis; Asian People; Cardiovascular Diseases; Humans
PubMed: 29422407
DOI: 10.1016/j.ajo.2018.01.024 -
Deutsche Medizinische Wochenschrift... Apr 1977
Topics: Adult; Arcus Senilis; Eye Diseases; Female; Humans; Hyperlipidemias; Phospholipids
PubMed: 852406
DOI: No ID Found -
Journal of the Royal Society of Medicine Mar 1981A study of arcus senilis in Caucasian men and women is reported. The prevalence of arcus senilis increases with age in both sexes and occurs more frequently in men. In...
A study of arcus senilis in Caucasian men and women is reported. The prevalence of arcus senilis increases with age in both sexes and occurs more frequently in men. In women arcus senilis is uncommon before the menopause. The occurrence of arcus senilis in Caucasians is not a significant finding, except in men under the age of 40 years, when it is associated with an increased risk of coronary artery disease.
Topics: Adult; Age Factors; Aged; Arcus Senilis; Coronary Disease; England; Eye Diseases; Female; Humans; Male; Menopause; Middle Aged; Sex Factors; White People
PubMed: 7205858
DOI: 10.1177/014107688107400308 -
Archives of Ophthalmology (Chicago,... Aug 1962
Topics: Arcus Senilis; Cornea; Corneal Diseases; Disease; Humans; Lipids
PubMed: 13861495
DOI: 10.1001/archopht.1962.00960030268020 -
A.M.A. Archives of Ophthalmology Apr 1959
Topics: Arcus Senilis; Cornea; Corneal Diseases; Disease; Histocytochemistry; Humans
PubMed: 13636543
DOI: No ID Found -
JAMA Nov 1975
Topics: Arcus Senilis; Carotid Artery Diseases; Eye Diseases; Female; Humans; Middle Aged
PubMed: 1242181
DOI: No ID Found -
Cell and Tissue Banking Sep 2014We developed a non-invasive device to quantify transparency (T), clear corneal diameter (CCD) excluding arcus senilis, and scleral rim diameter (SRD) of stored corneas....
We developed a non-invasive device to quantify transparency (T), clear corneal diameter (CCD) excluding arcus senilis, and scleral rim diameter (SRD) of stored corneas. The T value (expressed in % on a relative scale), based on the modulation transfer function principle, referred to the ratio of local contrasts of a special LED backlit chart measured with and without cornea. CCD and SRD (in mm) were automatically calculated by morphologic operations. Firstly, we assessed measurement reproducibility. We then determined the agreement of T and CCD values with 3-level scores given independently by three experts on 179 scientific corneas. Thirdly, an eye bank was equipped with the device, and 358 consecutive organ-cultured (OC) corneas were tested for donor- and storage- related factors possibly influencing T and CCD. Reproducibility of T, CCD and SRD measurements was high, with intraclass correlation coefficients of 0.982, 0.886, and 0.999 respectively. Capacity to discriminate the three levels of transparency and arcus senilis was good, with T of 20.0 (10.0-33.6), 38.3 (24.3-75.4) and 57.9 (33.9-90.0) % respectively for T deemed poor, average, and good (P < 0.001), and CCD of 9.8 (7.3-10.6), 10.5 (8.2-11.5), and 11.1 (9.9-12.0) mm respectively for arcus senilis deemed prominent, moderate or absent (P < 0.001). T was correlated with neither donor age nor endothelial cell density nor storage time, but slightly worsened during OC for corneas assessed twice. In conclusion, the device, which can be easily integrated in the facilities of an eye bank, provides reliable objective measurement of T, CCD, and SRD. This could be a useful tool for standardizing quality assessment of stored corneas and consequently optimizing their selection for penetrating, endothelial or anterior lamellar keratoplasty.
Topics: Arcus Senilis; Cornea; Corneal Transplantation; Endothelium, Corneal; Eye Banks; Humans; Organ Preservation; Reproducibility of Results; Tissue Donors
PubMed: 24306057
DOI: 10.1007/s10561-013-9414-9 -
Atherosclerosis Aug 2007Corneal arcus is a lipid-rich and predominantly extracellular deposit that forms at the corneoscleral limbus. It represents the most common peripheral corneal opacity... (Review)
Review
Corneal arcus is a lipid-rich and predominantly extracellular deposit that forms at the corneoscleral limbus. It represents the most common peripheral corneal opacity and is not associated with tissue breakdown but rather with the deposition of lipids. The deposition of cholesterol in the peripheral cornea and arterial wall are similar in that both are accelerated by elevated serum levels of atherogenic lipoproteins, such as low-density lipoproteins (LDL). Corneal arcus is more prevalent in men than in women and in Blacks than in Whites. Its prevalence increases with advancing age. It has been associated with hypercholesterolemia, xanthelasmas, alcohol, blood pressure, cigarette smoking, diabetes, age, and coronary heart disease. Nevertheless, it is not clear whether or not corneal arcus is an independent risk factor for coronary heart disease (CHD). The present systematic review examines the relationship of corneal arcus and CHD to determine if corneal arcus is an independent CHD risk factor. We conclude that there is no consensus that corneal arcus is an independent risk factor. The presence of corneal arcus in a young person should prompt a search for lipid abnormalities. Also, because corneal arcus represents physical evidence of early lipid deposition, its presence suggests the need for aggressive lipid therapy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arcus Senilis; Coronary Artery Disease; Dyslipidemias; Female; Humans; Male; Middle Aged; Risk Factors
PubMed: 17049531
DOI: 10.1016/j.atherosclerosis.2006.08.060