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Arteriosclerosis, Thrombosis, and... May 2020
Topics: Animals; Arteries; Arteriosclerosis; Disease Progression; Genetic Predisposition to Disease; Humans; Phenotype; Plaque, Atherosclerotic; Risk Factors; Vascular Remodeling; Vascular Stiffness
PubMed: 32320295
DOI: 10.1161/ATVBAHA.120.314208 -
Zeitschrift Fur Allgemeinmedizin Nov 1969
Review
Topics: Antihypertensive Agents; Arteriosclerosis; Arteriosclerosis Obliterans; Diet, Atherogenic; Female; Germany, West; Hemodynamics; Humans; Intracranial Arteriosclerosis; Male; Myocardial Infarction; Nephrosclerosis; Retrospective Studies; Smoking
PubMed: 4903599
DOI: No ID Found -
Przeglad Lekarski 2014The article summarizes the current knowledge concerning the diagnosis of atherosclerosis and therapeutic objectives. Atherosclerosis is one of the most common medical... (Review)
Review
The article summarizes the current knowledge concerning the diagnosis of atherosclerosis and therapeutic objectives. Atherosclerosis is one of the most common medical problems. It affects adults as well as children. It leads to clinically overt cardiovascular diseases (CVD), which are the cause of premature deaths. During its course, the formation of atherosclerotic plaque takes place, along with local inflammations artery walls. Gradually growing plaque does not cause clinical symptoms until the stenosis does not exceed 70-80% of the coronary vessel diameter, causing a marked reduction in blood flow to the heart muscle. The prevention of atherosclerosis and its complications requires an individual assessment of cardiovascular risk. In people without CVD symptoms, it is recommended to use SCORE risk card for Polish population, assessing the 10-year risk of cardiac death. A key element in combating atherosclerosis is to eliminate its risk factors by both implementing pro-health policies, as well as working with individual patients. An important objective is the proper control of blood pressure. It should not exceed 140/90 mmHg. A very important role is played by correct approach to patients with moderate or unusual cardiovascular risk. Despite knowing many facts about the mechanisms of atherosclerosis and its treatment, many issues still remain to be clarified. Finding methods to influence ongoing immune processes within arteries is of particular interest, which will soon make way to new therapeutic possibilities.
Topics: Adult; Arteriosclerosis; Cardiovascular Diseases; Child; Humans; Risk Assessment
PubMed: 25338337
DOI: No ID Found -
Nature Sep 2000Atherosclerosis, a disease of the large arteries, is the primary cause of heart disease and stroke. In westernized societies, it is the underlying cause of about 50% of... (Review)
Review
Atherosclerosis, a disease of the large arteries, is the primary cause of heart disease and stroke. In westernized societies, it is the underlying cause of about 50% of all deaths. Epidemiological studies have revealed several important environmental and genetic risk factors associated with atherosclerosis. Progress in defining the cellular and molecular interactions involved, however, has been hindered by the disease's aetiological complexity. Over the past decade, the availability of new investigative tools, including genetically modified mouse models of disease, has resulted in a clearer understanding of the molecular mechanisms that connect altered cholesterol metabolism and other risk factors to the development of atherosclerotic plaque. It is now clear that atherosclerosis is not simply an inevitable degenerative consequence of ageing, but rather a chronic inflammatory condition that can be converted into an acute clinical event by plaque rupture and thrombosis.
Topics: Animals; Arteriosclerosis; Coronary Disease; Humans; Risk Assessment
PubMed: 11001066
DOI: 10.1038/35025203 -
Deutsche Medizinische Wochenschrift... Mar 2019
Topics: Arteriosclerosis; Humans
PubMed: 30836399
DOI: 10.1055/a-0796-6875 -
Nihon Rinsho. Japanese Journal of... Aug 1993Arteriosclerosis is vascular disease characterized by thickening, hardening and remodelling of the arterial wall and classified into following three categories:... (Review)
Review
Arteriosclerosis is vascular disease characterized by thickening, hardening and remodelling of the arterial wall and classified into following three categories: atherosclerosis, Mönckeberg's medial calcific sclerosis, and arteriolosclerosis. Fibromuscular intimal thickening starts its development in the fetal age of the 6th month and continues to grow with aging. The specific topography of early atherosclerotic lesions is primarily attributed to wall shear stress, one of hemodynamic forces. The lesion will proliferate to form atherosclerosis when complicated by hyperlipidemia, hypertension, and/or other clinical risk factors. The major complications of atherosclerosis, stenosis of the arterial lumen and thrombus formation at ulcerated arterial walls, frequently cause such lethal diseases as ischemia of various pivotal organs or rupture of aneurysms.
Topics: Animals; Arteries; Arteriosclerosis; Endothelium, Vascular; Humans; Regional Blood Flow; Vascular Resistance
PubMed: 8411654
DOI: No ID Found -
Gerontology 2000In contrast to the well-known morphologic lesions of arteriosclerosis, the initial changes of the disease are less obvious. Commonly, functional disturbances of the... (Review)
Review
BACKGROUND
In contrast to the well-known morphologic lesions of arteriosclerosis, the initial changes of the disease are less obvious. Commonly, functional disturbances of the endothelium, endothelial dysfunction, are suggested. On the other hand the significance of age-dependent changes in the extracellular matrix with their important role in vessel wall permeability and other features associated with arteriosclerosis should not be overlooked. New topics deal with possible infectious factors, the genetic basis of the disease and the particularities of the unstable atheroma.
OBJECTIVE
Alterations in nitric monoxide and endothelin-1 balance of the endothelium are the key events in the initiation of arteriosclerosis induced by oxidized lipoproteins, cigarette smoking and endotoxin. This frequently supposed mechanism contrasts with earlier opinions on the primary alterations in glycosaminoglycan metabolism and other components of the extracellular matrix against atherogenic factors like hypertension, stress and physical inactivity. Based on a survey of the literature and our own experimental experiences, these changes in connection with the morphometrically determined age-conditioned increase in vascular wall thickness and the above-mentioned new topics on arteriosclerosis were analyzed.
CONCLUSION
The initial lesions of arteriosclerosis starting in youth seem to be fundamentally different from those beginning in old age. The first step in the development of fatty streaks in the arteries of young people is endothelial dysfunction with a decreased formation of nitric monoxide and an increased expression of adhesion molecules. In comparison the genesis of arteriosclerosis in advanced age is characterized by metabolic changes in the endothelium combined with age-conditioned alterations in the extracellular matrix resulting in faster progression of the disease in old age. The multicausal genesis of arteriosclerosis cannot be doubted even if cooperation with infectious factors cannot be excluded. The histopathologic peculiarities of unstable atheroma are described.
Topics: Aged; Aging; Arteriosclerosis; Humans
PubMed: 11044782
DOI: 10.1159/000022180 -
Human Pathology Mar 1971
Topics: Arteriosclerosis; Humans; Male; Middle Aged
PubMed: 5095242
DOI: 10.1016/s0046-8177(71)80027-8 -
Zentralblatt Fur Allgemeine Pathologie... 1989Arteriosclerosis is a process over time. It is described with reference to its historical dimension, evolution, aspect of comparative anatomy, and autonomy. The need is... (Review)
Review
Arteriosclerosis is a process over time. It is described with reference to its historical dimension, evolution, aspect of comparative anatomy, and autonomy. The need is emphasized for examining this process in its discontinuity, with a view to realizing the variable nature of causative relationships at different stages of the disease. It is of particular interest to clear up the factors responsible for progression of the arteriosclerotic process. In this context, attention should be focussed at the process of aging and its importance to arteriosclerosis in interaction with exogenous noxae.
Topics: Aging; Arteriosclerosis; Humans
PubMed: 2672679
DOI: No ID Found -
Journal of Clinical Lipidology 2011
Topics: Animals; Arteriosclerosis; Humans; Risk Factors
PubMed: 21392717
DOI: 10.1016/j.jacl.2011.01.007