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Disease-a-month : DM Jan 2011
Review
Topics: Asbestos; Asbestosis; History, 20th Century; Humans; Industry; Inhalation Exposure; Lung; Radiography
PubMed: 21281828
DOI: 10.1016/j.disamonth.2010.11.004 -
British Medical Journal Jul 1967
Review
Topics: Asbestosis; Humans; Occupational Diseases; Pulmonary Fibrosis
PubMed: 5339111
DOI: No ID Found -
Ugeskrift For Laeger Jun 2018Asbestos was used in numerous products until its total ban in Denmark in 1988. The prevalence of asbestosis and pleural plaques does not yet appear to be falling.... (Review)
Review
Asbestos was used in numerous products until its total ban in Denmark in 1988. The prevalence of asbestosis and pleural plaques does not yet appear to be falling. Unfortunately the statistics are unreliable due to errors in the Danish translation of the ICD-10 codes of the disease. In this review, clinical and radiologic diagnostic criteria of asbestosis and pleural plaques and recommendations for follow-up of patients are described. Typical changes on a high-resolution CT scan combined with relevant asbestos exposure is essential for the diagnosis. Asbestosis and pleural plaques are both notifiable in Denmark.
Topics: Asbestos; Asbestosis; Denmark; Humans; International Classification of Diseases; Occupational Diseases; Occupational Exposure; Pleural Diseases; Radiography; Tomography, X-Ray Computed; Translations
PubMed: 29938630
DOI: No ID Found -
Journal of Occupational Medicine. :... Jul 1991The term "asbestosis" usually has been applied to a disease characterized by diffuse pulmonary interstitial fibrosis. It was often associated with a significant adverse... (Review)
Review
The term "asbestosis" usually has been applied to a disease characterized by diffuse pulmonary interstitial fibrosis. It was often associated with a significant adverse impact on the individual. A review of case definitions employed in published research studies show stability of the criteria for asbestosis case definitions over the past decade. Nevertheless, additional modalities have been suggested for the early diagnosis of asbestosis. It is probable that the significance of such abnormalities may be different from that of usual asbestosis, and there is therefore a need to carefully define the manner in which the terms are used. Additional anomalies may be seen in asbestos-exposed individuals including small airway physiologic abnormality, pathologic evidence of inflammation near the airways, positive gallium scan, abnormal lung compliance, exercise test abnormalities, CAT scan findings, and high-resolution CAT scan findings.
Topics: Asbestosis; Humans; Lung; Prognosis; Pulmonary Diffusing Capacity; Vital Capacity; Work Capacity Evaluation
PubMed: 1890489
DOI: No ID Found -
International Journal of Occupational... 2004Croatians have been exposed to asbestos in the shipbuilding and asbestos-cement industries since 1945. The first cases of asbestosis were reported in 1961; 317 cases... (Review)
Review
Croatians have been exposed to asbestos in the shipbuilding and asbestos-cement industries since 1945. The first cases of asbestosis were reported in 1961; 317 cases were recorded from 1990 to 2000. The Croatian Cancer Registry recorded 248 malignant pleural mesotheliomas between 1991 and 1997, two thirds of which were attributable to occupational exposures to asbestos. The Croatian Asbestosis Patient Association was founded in 1998 to help victims. Croatian law defines the employer's responsibility for work-related health damage and compensation, but average legal proceedings for asbestosis claims take about seven years. Croatian law does not ban the manufacture and import of asbestos. Croatia as a transitional country is subject to socioeconomic pressures. Future approaches to the asbestos issue will depend on revised regulations, which are expected to conform to recommendations of the European Union by 2005.
Topics: Asbestosis; Consumer Advocacy; Croatia; Humans; Occupational Exposure; Public Policy; Workers' Compensation
PubMed: 15281379
DOI: 10.1179/oeh.2004.10.2.198 -
Revue Des Maladies Respiratoires Dec 1999Asbestosis is a rare pneumoconiosis secondary to inhalation of asbestos fibers. It follows sufficient professional exposures (more than 25 fibers x years/ml). The mean... (Review)
Review
Asbestosis is a rare pneumoconiosis secondary to inhalation of asbestos fibers. It follows sufficient professional exposures (more than 25 fibers x years/ml). The mean latency is 20 years. Clinical symptoms include exertion dyspnea, crackles and clubbing. Chest radiography the performances of which have been enhanced by the use of the ILO score shows fine reticular or reticulonodular opacities which predominate in pulmonary bases often in association with benign pleural abnormalities. An ILO score equal or higher than 1/1 is suggestive of asbestosis in the context of a compatible professional history. Pulmonary function is typical of diffuse interstitial lung disease. High resolution CT is the most performance investigation in particular in presence of asbestosis either minimal or of recent origin. The diagnosis of asbestosis is based on the professional exposure, a compatible interstitial lung and pleural disease and the exclusion of alternative hypothesis. The diagnosis can be comforted by bronchoalveolar lavage (cytology and biometeorology). Various evolutions are possible: stability, progression to respiratory insufficiency, increased incidence of bronchial carcinoma. Life expectancy is reduced in severe cases. There is no efficient medical treatment. Asbestosis is recognized as a professional disease. A better recognition of asbestosis necessitates a performance policy of depistage in populations with significant present or past exposure and an appropriate diagnostic strategy including high-resolution-CT.
Topics: Asbestosis; Humans; Mass Screening
PubMed: 10897851
DOI: No ID Found -
Proceedings of the Society For... Jan 1997Asbestosis is a diffuse pulmonary fibrotic process caused by the inhalation of asbestos fibers. Despite extensive investigations, the precise mechanisms regulating... (Review)
Review
Asbestosis is a diffuse pulmonary fibrotic process caused by the inhalation of asbestos fibers. Despite extensive investigations, the precise mechanisms regulating asbestos-induced lung damage are not fully understood. This review summarizes the important clinical manifestations and pathogenic mechanisms of asbestosis. We focus on the relatively new information that has emerged over the last several years. The diagnosis of asbestosis is often easily established by well-characterized criteria. Pulmonary physiologic testing and high-resolution computed tomography can detect clinically occult disease. The finding of asbestos bodies in the bronchoalveolar lavage fluid confirms that an individual has been exposed to asbestos but is of unclear significance in diagnosing asbestosis. Evidence reviewed herein suggests that asbestos pulmonary toxicity is due in part to the physical properties of the fibers, iron-catalyzed reactive oxygen species (ROS), and macrophage-derived cytokines and growth factors. Special emphasis is given to the hypothesis that iron-catalyzed hydroxyl radicals (HO.-) have a pivotal role in causing asbestosis. Definitive proof of this hypothesis is difficult to obtain since HO.- are highly reactive and their deleterious effects to cells may have occurred years prior to disease presentation. Despite these limitations, considerable data firmly support the notion that ROS have an important role in causing asbestos toxicity. Further, the iron content of asbestos or the redoxactive iron associated with or mobilized from the surface of the fibers is important in generating HO.- as well as in activating inflammatory cells. There also appears to be a close association between asbestos-induced ROS production and cellular toxicity and DNA damage. The full expression of asbestos-induced diseases likely involves the contribution of cytokines, growth factors, proteases, and other inflammatory cell products. Many of the mechanisms by which asbestos- and inflammation-induced ROS activate specific genes in pulmonary cells remain to be elucidated.
Topics: Asbestosis; Cytokines; Growth Substances; Humans; Lung; Reactive Oxygen Species
PubMed: 9012357
DOI: 10.3181/00379727-214-44065 -
Lancet (London, England) Dec 1977
Topics: Asbestosis; Humans; Terminology as Topic
PubMed: 73933
DOI: 10.1016/s0140-6736(77)90474-3 -
Radiography Apr 1971
Topics: Adult; Asbestos; Asbestosis; Humans; Male; Mesothelioma; Middle Aged; Mining; Occupational Medicine; Pleural Diseases; Pleural Neoplasms; Pulmonary Fibrosis; Radiography, Thoracic
PubMed: 5572879
DOI: No ID Found -
The Western Journal of Medicine Jul 1979
Topics: Asbestosis; Humans
PubMed: 483791
DOI: No ID Found