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Indian Pediatrics Jan 2022
Topics: Anetoderma; Humans; Skin
PubMed: 35060490
DOI: No ID Found -
JAMA Dermatology Apr 2021
PubMed: 33851962
DOI: 10.1001/jamadermatol.2021.0440 -
Clinical Rheumatology Dec 2020
Topics: Anetoderma; Antibodies, Antiphospholipid; Humans; Skin Diseases
PubMed: 32776312
DOI: 10.1007/s10067-020-05321-y -
Actas Dermo-sifiliograficas Oct 2023
PubMed: 37797881
DOI: 10.1016/j.ad.2022.11.021 -
Skinmed 2011
Topics: Anetoderma; Antibodies, Antiphospholipid; Elastic Tissue; Humans; Skin
PubMed: 21675492
DOI: No ID Found -
Lupus Apr 2021Antiphospholipid syndrome (APS) is an acquired thrombophilic disorder in which autoantibodies are produced against a variety of phospholipids and phospholipid-binding... (Review)
Review
Antiphospholipid syndrome (APS) is an acquired thrombophilic disorder in which autoantibodies are produced against a variety of phospholipids and phospholipid-binding proteins. The purpose of this article is to review cutaneous findings in patients with APS diagnosis. An overview regarding prevalence, description, pathogenesis and histopathology, are described for cutaneous manifestations of APS.
Topics: Adult; Aged; Anetoderma; Antibodies, Anticardiolipin; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Biopsy; Female; Gangrene; Humans; Livedo Reticularis; Lupus Coagulation Inhibitor; Male; Malignant Atrophic Papulosis; Middle Aged; Necrosis; Prevalence; Skin Diseases; Ulcer; Vasculitis
PubMed: 33583236
DOI: 10.1177/0961203321990100 -
The American Journal of Dermatopathology Feb 2019After a review of the physiology in the formation and degradation of cutaneous elastic tissue, we describe the clinicopathologic disorders characterized by increased and... (Review)
Review
After a review of the physiology in the formation and degradation of cutaneous elastic tissue, we describe the clinicopathologic disorders characterized by increased and decreased cutaneous elastic tissue. Cutaneous disorders characterized by increased and/or abnormal elastic tissue in the dermis include elastoma, also named nevus elasticus, dermatosis lenticularis disseminata, pseudoxanthoma elasticum, late-onset focal dermal elastosis, linear focal elastosis, elastoderma, elastofibroma dorsi, and elastosis perforans serpiginosa. In some of these conditions, the specific histopathologic diagnosis may be rendered with hematoxylin-eosin stain, whereas in other ones special elastic tissue stains are necessary to demonstrate the anomalies. Cutaneous disorders characterized by decreased dermal elastic tissue include nevus anelasticus, papular elastorrhexis, perifollicular elastolysis, anetoderma cutis laxa, postinflammatory elastolysis and cutis laxa, white fibrous papulosis of the neck, pseudoxanthoma elasticum-like papillary dermal elastolysis, and mid dermal elastolysis. In most of these conditions, the histopathologic anomalies are only seen with elastic tissue stains, and cutaneous biopsies of these processes stained with hematoxylin-eosin show appearance of normal skin. The diagnosis of some of these disorders characterized by increased or decreased elastic dermal tissue should be followed by general exploration of the patient to rule out associated severe systemic anomalies, and in some cases, a genetic counseling should be offered to the family.
Topics: Connective Tissue Diseases; Elastic Tissue; Humans; Skin Diseases
PubMed: 30688725
DOI: 10.1097/DAD.0000000000001275 -
Annales de Dermatologie Et de... Mar 2021Herein, the different skin manifestations in patients with lupus erythematosus are reviewed, and their diagnostic, pathogenic and prognostic relevance are discussed, as... (Review)
Review
Herein, the different skin manifestations in patients with lupus erythematosus are reviewed, and their diagnostic, pathogenic and prognostic relevance are discussed, as well as their impact on therapeutic choices. The so-called specific lesions of LE result from an autoimmune pathomechanism and they allow diagnosis of LE by simple clinicopathological correlation since the findings are characteristic. They include the classic acute, subacute and chronic variants, characterised microscopically by interface dermatitis; the dermal variants of lupus, such as tumid lupus, displaying dermal perivascular lymphocytic infiltrate with mucin deposition under the microscope, and lupus profundus, in which lymphocytic lobular panniculitis progressing to hyaline fibrosis is found. Antimalarials are the treatment of choice for patients with specific LE lesions. The presence of some dermatological signs is the result of thrombotic vasculopathy. Their recognition allows the identification of lupus patients at increased cardiovascular risk and with a worse overall prognosis. Those signs include reticulated erythema on the tip of the toes, splinter hemorrhages, atrophie blanche, pseudo-Degos lesions, racemosa-type livedo, anetoderma, ulceration and necrosis. Those clinical manifestations, often subtle, must be recognised, and if present, patients should be treated with antiplatelet drugs. Finally, neutrophilic cutaneous lupus erythematosus includes a few entities that suggest that autoinflammatory mechanisms might play a key role in certain lupus manifestations. Among those entities, it is very important to diagnose neutrophilic urticarial dermatosis, which can mimic a classic lupus flare, because it is characterised by rash with joint pain, but immunosuppressants are not helpful. Dapsone is the treatment of choice.
Topics: Humans; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Discoid; Lupus Erythematosus, Systemic; Skin Diseases, Vascular; Symptom Flare Up
PubMed: 33483145
DOI: 10.1016/j.annder.2020.08.052 -
The American Journal of Dermatopathology Apr 1996Atrophoderma elastolytica discreta is the clinicopathologic name for a unique entity herein first described in a patient with cutaneous lesions simulating atrophoderma...
Atrophoderma elastolytica discreta is the clinicopathologic name for a unique entity herein first described in a patient with cutaneous lesions simulating atrophoderma of Pasini and Pierini but coupled with histopathologic changes of anetoderma. The clinical and histological findings seen here have not been previously seen in the many variants of anetoderma, and, as such, they are sui generis evidence of a new entity in clinical dermatology.
Topics: Abdomen; Atrophy; Edema; Elastic Tissue; Female; Humans; Middle Aged; Skin; Thigh
PubMed: 8739999
DOI: 10.1097/00000372-199604000-00017