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Comptes Rendus Des Seances de La... 1958
Topics: Abnormalities, Severe Teratoid; Adrenal Cortex; Anencephaly; Atrophy
PubMed: 13597246
DOI: No ID Found -
American Journal of Diseases of... Aug 1949
Topics: Heredity; Humans; Muscular Atrophy; Muscular Atrophy, Spinal; Spinal Muscular Atrophies of Childhood
PubMed: 18135521
DOI: 10.1001/archpedi.1949.02030050237007 -
Marseille Medical 1965
Topics: Alcoholism; Atrophy; Cerebellar Diseases; Humans; Nervous System Diseases
PubMed: 14292284
DOI: No ID Found -
European Neurology 1977Two cases of chronic spinal muscular atrophy simulating the clinical picture of the facioscapulohumeral type and limb-girdle type of muscular dystrophy are reported....
Two cases of chronic spinal muscular atrophy simulating the clinical picture of the facioscapulohumeral type and limb-girdle type of muscular dystrophy are reported. Both patients had a waddling gait, Gowers' maneuver in arising, terminal atrophies and pseudohypertrophies of some muscles, marked fasciculations, and fascicular tremor. The electromyogram revealed signs of anterior horn cell disease. Calf muscle biopsy (case 2) revealed 'myopathic' changes.
Topics: Chronic Disease; Diagnosis, Differential; Electromyography; Humans; Male; Middle Aged; Motor Neurons; Muscular Atrophy; Muscular Dystrophies; Spinal Cord Diseases; Syndrome
PubMed: 615721
DOI: 10.1159/000114885 -
Lancet (London, England) Apr 1980Clinical heterogeneity within the spinal muscular atrophies (SMA) has long been a source of confusion for questions of prognosis and genetic counselling. Comprehensive...
Clinical heterogeneity within the spinal muscular atrophies (SMA) has long been a source of confusion for questions of prognosis and genetic counselling. Comprehensive clinical and genetic analyses of 240 consecutive index cases from two English centres (The English SMA Study) have enabled some nosological questions to be resolved. The different SMA syndromes can be discriminated by (a) age at the first clinical signs of the disease, (b) pattern of muscle involvement, (c) age at death of other patients within an affected kindred, and (d) genetic evidence. Seven different SMA syndromes can be defined clinically and genetically; thirteen mutant genes are incriminated. Prevalence and incidence figures are presented. SMA type I (Werdnig-Hoffman disease) and chronic childhood SMA together comprise 74% of all SMA cases. The classification of the spinal muscular atrophies presented also provides the differential diagnosis for newly presenting cases.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Diagnosis, Differential; England; Genes, Dominant; Genes, Recessive; Humans; Infant; London; Middle Aged; Motor Neurons; Muscular Atrophy; Nerve Degeneration; Neuromuscular Diseases; Spinal Diseases
PubMed: 6103267
DOI: 10.1016/s0140-6736(80)90847-8 -
International Journal of Molecular... Sep 2022Long-term exposure to microgravity leads to muscle atrophy, which is primarily characterized by a loss of muscle mass and strength and reduces one′s functional...
Long-term exposure to microgravity leads to muscle atrophy, which is primarily characterized by a loss of muscle mass and strength and reduces one′s functional capability. A weightlessness-induced muscle atrophy model was established using the tail suspension test to evaluate the intervention or therapeutic effect of low-intensity pulsed ultrasound (LIPUS) on muscle atrophy. The rats were divided into five groups at random: the model group (B), the normal control group (NC), the sham-ultrasound control group (SUC), the LIPUS of 50 mW/cm2 radiation group (50 UR), and the LIPUS of 150 mW/cm2 radiation group (150 UR). Body weight, gastrocnemius weight, muscle force, and B-ultrasound images were used to evaluate muscle atrophy status. Results showed that the body weight, gastrocnemius weight, and image entropy of the tail suspension group were significantly lower than those of the control group (p < 0.01), confirming the presence of muscle atrophy. Although the results show that the muscle force and two weights of the rats stimulated by LIPUS are still much smaller than those of the NC group, they are significantly different from those of the pure tail suspension B group (p < 0.01). On day 14, the gastrocnemius forces of the rats exposed to 50 mW/cm2 and 150 mW/cm2 LIPUS were 150% and 165% of those in the B group. The gastrocnemius weights were both 135% of those in the B group. This suggests that ultrasound can, to a certain extent, prevent muscular atrophy.
Topics: Animals; Rats; Body Weight; Muscle, Skeletal; Muscular Atrophy; Tail; Ultrasonic Waves
PubMed: 36142280
DOI: 10.3390/ijms231810369 -
European Journal of Cancer & Clinical... Jan 1985Despite vast knowledge on liver regeneration, little is known about the effect of active liver atrophy and regeneration on tumor growth. Ligation of a branch of the...
Despite vast knowledge on liver regeneration, little is known about the effect of active liver atrophy and regeneration on tumor growth. Ligation of a branch of the portal vein to the one or two anterior lobes was performed in inbred Wistar rats. This induces acute atrophy of the anterior and regeneration of the other lobes. During the same operation a tumor cell suspension (NGW1--adenocarcinoma) was inoculated in liver lobes undergoing atrophy and regeneration. Tumor volume and weight were measured and the histologic appearance was assessed. During the early and active phases the tumor growth was significantly accelerated in regenerating lobes and partially inhibited in rapidly atrophied segments. After the regeneration and atrophy was completed the normal pattern of growth was re-established in both parts of the liver. The results suggest that tumor growth is affected in proportion to regenerative response. They further suggest that portal branch ligation is of limited value in surgical palliation of liver tumors. The risk for further induction of growth of clinically undetected tumor foci in the remaining liver tissue appears to be small, although a significant, but short-lasting, stimulatory response was found.
Topics: Animals; Atrophy; Ligation; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Portal Vein; Rats; Rats, Inbred Strains
PubMed: 4038652
DOI: 10.1016/0277-5379(85)90210-x -
Nederlands Tijdschrift Voor Geneeskunde Jan 1951
Topics: Atrophy; Cerebellar Diseases; Cerebellum; Humans
PubMed: 14806659
DOI: No ID Found -
Biofizika 2015From our earlier experiments on the study of changes in titin content and the level of its phosphorylation in skeletal muscles, atrophied during space flight,...
From our earlier experiments on the study of changes in titin content and the level of its phosphorylation in skeletal muscles, atrophied during space flight, hibernation, and also because of the development of alcohol-induced lesions it has been suggested that an increase in the degree of titin phosphorylation results in increased proteolytic degradation of this protein, that contributes to the development of skeletal muscle atrophy.
Topics: Animals; Connectin; Ethanol; Gene Expression; Hibernation; Humans; Mice; Muscular Atrophy; Phosphorylation; Protein Isoforms; Protein Stability; Proteolysis; Rats; Sciuridae; Space Flight; Weightlessness
PubMed: 26394485
DOI: No ID Found -
Bulletin Medical Sep 1950
Topics: Arteriosclerosis; Atrophy; Brain; Humans; Optic Atrophy; Optic Nerve
PubMed: 14772587
DOI: No ID Found