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The American Journal of Medicine Jun 1967
Review
Topics: Adult; DNA; Humans; Lymphocytes; Middle Aged
PubMed: 5338481
DOI: 10.1016/0002-9343(67)90073-3 -
Hepatobiliary & Pancreatic Diseases... Oct 2021
Topics: Acute Disease; Hepatitis; Humans; Lymphocytes
PubMed: 34340920
DOI: 10.1016/j.hbpd.2021.07.006 -
International Journal of Laboratory... Feb 2022
Topics: COVID-19; Humans; Lymphocytes; Pleural Effusion; Pneumonia; SARS-CoV-2
PubMed: 34146462
DOI: 10.1111/ijlh.13630 -
International Journal of Laboratory... Oct 2022
Topics: Antigens, CD; Hodgkin Disease; Humans; Lymph Nodes; Lymphocytes
PubMed: 35713576
DOI: 10.1111/ijlh.13910 -
Laboratory Medicine Sep 2021Platelet and erythrocyte agglutination is known to happen in vitro due to EDTA or temperature-induced cold antibodies. Leukocyte agglutination is far less common, and...
Platelet and erythrocyte agglutination is known to happen in vitro due to EDTA or temperature-induced cold antibodies. Leukocyte agglutination is far less common, and its etiology is not always known. The 2 cases presented herein are of low-grade B-cell lymphomas consistent with splenic marginal-zone lymphoma that presented with lymphocyte agglutination. In Case A, the lymphocyte aggregates were not resolved by warming the sample or by non-EDTA anticoagulation. In Case B, the lymphocyte aggregates were largely resolved by warming the specimen at 37°C for 15 minutes. The 2 cases presented herein further show that the etiology of lymphocyte aggregation can have multiple causes, even within the same disease process.
Topics: Agglutination; Blood Platelets; Humans; Lymphocytes; Lymphoma, B-Cell
PubMed: 33900388
DOI: 10.1093/labmed/lmab010 -
International Reviews of Immunology Aug 2013Lupus is a complex autoimmune rheumatic disease of unknown aetiology. The disease is associated with diverse features of immunological abnormality in which B-lymphocytes... (Review)
Review
Lupus is a complex autoimmune rheumatic disease of unknown aetiology. The disease is associated with diverse features of immunological abnormality in which B-lymphocytes play a central role. However, the cause of atypical B-lymphocyte responses remains unclear. In this article, we provide a synopsis of current knowledge on intracellular signalling abnormalities in B-lymphocytes in lupus and their potential effects on the response of these cells in mouse models and in patients. There are numerous reported defects in the regulation of intracellular signalling proteins and pathways in B-lymphocytes in lupus that, potentially, affect critical biological responses. Most of the evidence for these defects comes from studies of disease models and genetically engineered mice. However, there is also increasing evidence from studying B-lymphocytes from patients and from genome-wide linkage analyses for parallel defects to those observed in mice. These studies provide molecular and genetic explanations for the key immunological abnormalities associated with lupus. Most of the new information appears to relate to defects in intracellular signalling that impact B-lymphocyte tolerance, cytokine production and responses to infections. Some of these abnormalities will be discussed within the context of disease pathogenesis.
Topics: Animals; B-Lymphocytes; Calcium Signaling; Humans; Immunity, Innate; Lupus Erythematosus, Systemic; Receptors, Immunologic; Signal Transduction
PubMed: 23768155
DOI: 10.3109/08830185.2013.788648 -
Clinical Laboratory Jun 2020Atypical lymphocytes (AL), or reactive lymphocyte, exist in peripheral blood when stimulated by viral infection, drugs, inflammatory signals or allergens. Studies have...
BACKGROUND
Atypical lymphocytes (AL), or reactive lymphocyte, exist in peripheral blood when stimulated by viral infection, drugs, inflammatory signals or allergens. Studies have shown that specific changes in peripheral blood (PB) analysis can predict morphological changes in blood cells. The objective of this study was to explore the value of the peripheral blood lymphocyte count in predicting the presence of AL.
METHODS
One hundred ninety-nine outpatients were selected from Beijing Chao-Yang Hospital, Capital Medical University from January to April 2015 and underwent manual cell classification with evaluation of complete clinical data. The results of manual classification of peripheral blood leukocytes and peripheral blood routine analysis were assessed, and the correlation between peripheral blood lymphocyte counts and presence of atypical lympho-cytes evaluated using receiver operating characteristic (ROC) curves for each subject.
RESULTS
Peripheral blood lymphocytes ≥ 2.375 x 109/L was found to be the optimal cutoff point for predicting atypical lymphocytes. The area under the curve (AUC), 95% confidence interval (CI), sensitivity and specificity were 0.7984, 0.7121 - 0.8846, 68.42%, and 82.8%, respectively, while the accuracy was moderate. When the proportion of peripheral blood lymphocytes was greater than 35.90%, the AUC, 95% CI, sensitivity, and specificity were 0.8729, 0.8092 - 0.9366, 89.47%, and 76.34%, respectively, while the accuracy was moderate.
CONCLUSIONS
The peripheral blood lymphocyte count of a patient has good predictive value for the existence of atypical lymphocytes, which is helpful for clinical diagnosis.
Topics: Diagnostic Tests, Routine; Female; Hematologic Tests; Humans; Leukocyte Count; Lymphocyte Activation; Lymphocyte Count; Lymphocyte Subsets; Lymphocytes; Lymphocytosis; Lymphopenia; Lymphoproliferative Disorders; Male; Middle Aged; Predictive Value of Tests
PubMed: 32538050
DOI: 10.7754/Clin.Lab.2019.191113 -
Polski Merkuriusz Lekarski : Organ... May 2008Atypical lymphocytes or reactive are cells that become large as a result of antigen stimulation. This cells usually are associated with viral illnesses, however they can... (Review)
Review
Atypical lymphocytes or reactive are cells that become large as a result of antigen stimulation. This cells usually are associated with viral illnesses, however they can also be present as result of drug reactions, immunisations, humoral diseases and auto-immune disorders.
Topics: Animals; Antibody Formation; Autoimmune Diseases; Hematologic Diseases; Humans; Lymphocyte Activation; Lymphocytes; Virus Diseases
PubMed: 18634392
DOI: No ID Found -
Cancer Reports (Hoboken, N.J.) Sep 2022The "accelerated" chronic lymphocytic leukemia (aCLL) is a relatively rare form of CLL progression. The expanded proliferation centers in aCLL have been associated with...
BACKGROUND
The "accelerated" chronic lymphocytic leukemia (aCLL) is a relatively rare form of CLL progression. The expanded proliferation centers in aCLL have been associated with adverse prognostic features and propensity to more aggressive behavior with shorter survival.
CASE
An atypical case of aCLL with distinct features is described. A 66-year-old female presented with a marrow replacing process associated with multiple osseous metastases and trivial lymphadenopathy. Bone biopsy revealed an unspecified low-grade B cell lymphoproliferative disorder that demonstrated a suboptimal response to standard chemotherapy. Subsequent lymph node biopsy demonstrated findings consisted with aCLL. The distinguishing features of the case were, in addition to bone involvement, the lagging peripheral lymphocytosis and a striking pattern of the chromatin clumping with a prominent "shattered" appearance reminiscent of Pelger-Huet-like dysplastic anomaly. A targeted next-generation sequencing (NGS) assay detected pathogenic mutations in TP53 and SF3B1. In contrast to chemotherapy, the case demonstrated an excellent response to imbruvica.
CONCLUSION
The noted peculiarities could potentially distinguish this case as a novel, rare variant of aCLL.
Topics: Adenine; Aged; B-Lymphocytes; Chromatin; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Piperidines
PubMed: 35075812
DOI: 10.1002/cnr2.1601 -
Gastroenterology Clinics of North... Mar 2002Collagenous and lymphocytic colitis are atypical colitides that should be considered in elderly patients with unexplained diarrhea. The lack of natural history data and... (Review)
Review
Collagenous and lymphocytic colitis are atypical colitides that should be considered in elderly patients with unexplained diarrhea. The lack of natural history data and apparent underreporting of these disorders have made the determination of true incidence difficult. Better insight into the pathogenesis and heightened awareness of these conditions will lead to earlier diagnosis and more effective treatment.
Topics: Aged; Colitis; Collagen; Female; Humans; Lymphocytes; Male; Middle Aged
PubMed: 12122739
DOI: 10.1016/s0889-8553(01)00016-4