-
Israel Journal of Medical Sciences Sep 1985
Topics: Aurothioglucose; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Gold; Granuloma; Humans; Liver; Liver Diseases; Middle Aged
PubMed: 3932253
DOI: No ID Found -
The American Journal of Medicine Dec 1983Despite a progressively more favorable prognosis in systemic lupus erythematosus (SLE) a need remains for therapeutic agents with greater benefit and less toxicity than...
Despite a progressively more favorable prognosis in systemic lupus erythematosus (SLE) a need remains for therapeutic agents with greater benefit and less toxicity than corticosteroids and immunosuppressive drugs. Therefore, we treated 16 patients with SLE but without renal diseases with auranofin, a drug with proved efficacy and safety in rheumatoid arthritis. A modest diminution in overall disease activity, as judged by the investigators, and a reduction in maintenance corticosteroid dosage was achieved. However, neither laboratory assessments nor more objective clinical measurements of SLE disease activity disclosed any improvement over baseline. One case each of proteinuria and thrombocytopenia was observed, most likely related to underlying disease and not the drug, suggesting that auranofin may be safe in patients with SLE. A controlled trial, utilizing a broader spectrum of patients with SLE, may be warranted.
Topics: Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Auranofin; Aurothioglucose; Drug Therapy, Combination; Female; Gold; Humans; Lupus Erythematosus, Systemic; Male; Patient Dropouts; Pilot Projects
PubMed: 6419600
DOI: 10.1016/0002-9343(83)90491-6 -
The Journal of Rheumatology Oct 2001We assessed nitritoid reactions, which are a well recognized side effect of chrysotherapy that occur in roughly 5% of patients taking gold sodium thiomalate (GST). (Review)
Review
OBJECTIVE
We assessed nitritoid reactions, which are a well recognized side effect of chrysotherapy that occur in roughly 5% of patients taking gold sodium thiomalate (GST).
METHODS
Between January 1996 and January 2000, 8 patients followed in our gold monitoring program at Mary Pack Arthritis Centre experienced nitritoid reactions observed by the clinic nurse. We undertook a chart review to determine the risk factors, timing, course, and outcome of nitritoid reactions.
RESULTS
Patients' ages ranged from 36 to 69 years, and 7 of 8 were women. Duration of gold therapy prior to nitritoid reactions ranged from 13 months to 13 years. Seven had previously had mucocutaneous reactions, and one experienced gold dermatitis following a nitritoid reaction. Two of 8 patients were taking angiotensin converting enzyme inhibitor agents. Seven reactions were classified as mild, and one was a severe reaction with hypotension, syncope, and angina.
CONCLUSIONS
Management includes a high index of suspicion in patients experiencing nausea, flushing, or dizziness following gold injections, switching from GST to gold sodium aurothioglucose, injection in the recumbent position, and observation for 20 minutes after injections in individual patients.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis; Aurothioglucose; Drug Eruptions; Female; Flushing; Gold Sodium Thiomalate; Humans; Hypotension; Male; Middle Aged; Syncope
PubMed: 11669157
DOI: No ID Found -
The American Journal of Medicine Dec 1983Auranofin, an oral gold-containing medication for the treatment of rheumatoid arthritis, has unique chemical, pharmacologic, and kinetic characteristics. Clinical... (Clinical Trial)
Clinical Trial
Auranofin, an oral gold-containing medication for the treatment of rheumatoid arthritis, has unique chemical, pharmacologic, and kinetic characteristics. Clinical improvement is achieved with lower blood gold levels than with parenteral gold compounds. More than 3,000 patients with rheumatoid arthritis in 27 countries have been treated with auranofin to date. In many patients, experience with auranofin extends beyond three years, and in some it exceeds four years. Available information indicates that auranofin (3 mg twice a day) is superior to placebo therapy, with similar efficacy and greater safety than gold sodium thiomalate.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Auranofin; Aurothioglucose; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Dose-Response Relationship, Drug; Gold; Humans; Rats; Tissue Distribution
PubMed: 6419601
DOI: 10.1016/0002-9343(83)90480-1 -
Comptes Rendus Des Seances de La... 1973
Topics: Animals; Aurothioglucose; Eating; Fasting; Gold; Hypothalamus; Mice; Staining and Labeling
PubMed: 4141273
DOI: No ID Found -
The Journal of Rheumatology Feb 1983Serum, blood and cell-associated gold were determined at various time periods after intravenous administration of 1 mg Au/kg of auranofin (AF), gold sodium thiomalate...
Serum, blood and cell-associated gold were determined at various time periods after intravenous administration of 1 mg Au/kg of auranofin (AF), gold sodium thiomalate (GSTM) and aurothioglucose (GTG). AF gold exhibited an early phase of decay with high levels of cell-association; whereas, after 72 h cell-associated gold was not detectable. In contrast, GSTM and GTG serum gold values were generally higher than blood values since cell-associated gold rarely occurred. These observations suggest that, in contrast to GSTM and GTG, intravenous administration of AF results in a dynamic equilibrium of gold between the cellular and serum compartments of blood.
Topics: Animals; Auranofin; Aurothioglucose; Blood Cells; Gold; Gold Sodium Thiomalate; Injections, Intravenous; Male; Rats; Rats, Inbred Strains; Time Factors
PubMed: 6405031
DOI: No ID Found -
Arthritis and Rheumatism 1976A 4-year prospective clinical study of chrysotherapy was designed to reexamine old beliefs and traditions, and to test potentially new approaches to chrysotherapy. The... (Comparative Study)
Comparative Study
A 4-year prospective clinical study of chrysotherapy was designed to reexamine old beliefs and traditions, and to test potentially new approaches to chrysotherapy. The standard weekly dosage of 50 mg was compared to that based on 1 mg/kg body weight; no significant differences were found. The rapidly absorbed aqueous thiomalate was compared to the slowly absorbed oil repository thioglucose; the latter produced significantly less side effects and an appreciably higher percentage of improvement. Almost half (43%) of nonresponders on standard regimen had a satisfactory clinical response at higher dosage levels without increase in toxicity. Some of these findings vary so much with traditional beliefs and practices that the authors urge caution in their interpretation. But generally speaking these problems are technical and do not detract from the conviction that chrysotherapy is valuable and comparatively safe in the management of rheumatoid arthritis and that it deserves more widespread application in clinical practice.
Topics: Arthritis, Rheumatoid; Aurothioglucose; Gold; Gold Sodium Thiomalate; Humans; Prospective Studies
PubMed: 826257
DOI: 10.1002/art.1780190613 -
MMW, Munchener Medizinische... Sep 1982
Topics: Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aurothioglucose; Drug Therapy, Combination; Female; Gold; Humans; Propionates; Stevens-Johnson Syndrome
PubMed: 6813706
DOI: No ID Found -
Veterinarni Medicina Oct 1977Aurothioglucose dose of 1 mg g-1 1. w. was applied intraperitoneally to experimental female mice. After 24 hours the animals were decapitated and samples for...
Aurothioglucose dose of 1 mg g-1 1. w. was applied intraperitoneally to experimental female mice. After 24 hours the animals were decapitated and samples for ultrastructural examination were immediately taken from the region of the hypothalamic ventromedial nucleus. The following findings were obtained from the study of 243 electronograms of 8 experimental animals: 1. dense round particles 0.034 to 0.016 mu in size, representing the gold of aurothioglucose; 2. parenchymatous dystrophy of the mitochondria; 3. peeling off of the individual layers of myelin sheath and the granularity of these layers corresponding to the disintegration of nerve fibres.
Topics: Animals; Aurothioglucose; Female; Gold; Hypothalamus; Mice; Mitochondria; Myelin Sheath; Neuroglia
PubMed: 414410
DOI: No ID Found -
Helvetica Physiologica Et... 1957
Topics: Animals; Aurothioglucose; Mice; Obesity; Weight Loss
PubMed: 13474592
DOI: No ID Found