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Journal of AOAC International 2001Liquid chromatographic (LC) methods were developed for quantitating the potential avian contraceptive DiazaCon in quail feed and serum. DiazaCon was extracted from...
Liquid chromatographic (LC) methods were developed for quantitating the potential avian contraceptive DiazaCon in quail feed and serum. DiazaCon was extracted from ground quail feed with basic n-butyl chloride. The n-butyl chloride extract was evaporated to dryness. The DiazaCon residues were dissolved in an aqueous methanolic ion pairing solution and quantitated by LC at 206 nm. Avian sera was combined with an equal volume of a pH 4 aqueous solution of ion pairing reagent and filtered to remove interfering proteins. DiazaCon was quantitated by LC. Mean recoveries for 500 and 2000 ppm fortified feed were 89.1 and 91.0%, respectively. The mean recovery for sera fortified at 5 levels ranging from 35 to 2000 ppm was 84.9%. Method limits of detection were approximately 14 and 13 ppm for feed and sera, respectively.
Topics: Animal Feed; Animals; Azacosterol; Chromatography, High Pressure Liquid; Contraceptive Agents; Coturnix; Hydrogen-Ion Concentration; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Quality Control
PubMed: 11417624
DOI: No ID Found -
Archives of Dermatology Aug 1965A new inhibitor of cholesterol synthesis, 20,25 diazachlestenol, produced myotonia in 31 persons; and, in six of these, a keratoderma which resembles the natural...
A new inhibitor of cholesterol synthesis, 20,25 diazachlestenol, produced myotonia in 31 persons; and, in six of these, a keratoderma which resembles the natural disease, keratoderma climactericum. These observations further emphasize the importance of normal lipid synthesis in orderly cornification.
Topics: Azacosterol; Female; Humans; Keratoderma, Palmoplantar; Middle Aged; Myotonia
PubMed: 11850925
DOI: No ID Found -
Life Sciences (1962) Jun 1964
Topics: Aorta; Azacosterol; Blood; Brain; Brain Chemistry; Cholesterol; Desmosterol; Liver; Pharmacology; Rats; Research; Sterols; Triparanol
PubMed: 14187496
DOI: 10.1016/0024-3205(64)90166-3 -
Proceedings of the Society For... 1964
Topics: Azacosterol; Cholesterol; Chromatography; Liver; Metabolism; Rats; Research; Spectrophotometry; Sterols
PubMed: 14230408
DOI: 10.3181/00379727-116-29430 -
The Journal of Pharmacy and Pharmacology Nov 1979
Topics: Animals; Azacosterol; Carnitine; Cycloheximide; Dactinomycin; Drug Tolerance; Ethanol; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Vitamin E
PubMed: 41903
DOI: 10.1111/j.2042-7158.1979.tb13648.x