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Proceedings of the National Academy of... Jan 1978We have developed a quantitative forward mutation assay using Salmonella typhimurium, in which resistance to the purine analog 8-azaguanine is used as a genetic marker....
We have developed a quantitative forward mutation assay using Salmonella typhimurium, in which resistance to the purine analog 8-azaguanine is used as a genetic marker. We present the assay protocol, the concentration-dependent toxicity and mutagenicity of five known mutagens (N-methyl-N'-nitro-N-nitrosoguanidine, ICR-191, 9-aminoacridine, dimethylnitrosamine, and benzo[a]pyrene), and reconstruction experiments testing the assay for possible bias. The relative merits of forward versus reverse mutation assays are discussed.
Topics: Azaguanine; Biological Transport; Cytosol; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Mutagens; Mutation; Pentosyltransferases; Salmonella typhimurium; Xanthines
PubMed: 343109
DOI: 10.1073/pnas.75.1.410 -
Proceedings of the Society For... Nov 1951
Topics: Animals; Azaguanine; Guanine; Humans; Leukemia, Experimental; Purine Nucleosides
PubMed: 14911930
DOI: 10.3181/00379727-78-19118 -
Acta Crystallographica. Section B:... Dec 1968
Topics: Azaguanine; Chemical Phenomena; Chemistry; Crystallography
PubMed: 5756972
DOI: 10.1107/s0567740868004863 -
Science (New York, N.Y.) Jan 1965The perpendicular distance between the planes of successive molecules of 8-azaguanine, in crystals of 8-azaguanine monohydrate, is 3.25 A. This distance indicates...
The perpendicular distance between the planes of successive molecules of 8-azaguanine, in crystals of 8-azaguanine monohydrate, is 3.25 A. This distance indicates intermolecular interaction of the charge-transfer type. 8-Azaguanine may act as a cell poison by forming a charge-transfer complex within the bacterial RNA.
Topics: Azaguanine; Chemical Phenomena; Chemistry; Enterococcus faecalis; RNA; RNA, Bacterial; Research
PubMed: 14237206
DOI: 10.1126/science.147.3657.507 -
Molecular Pharmacology Sep 1965
Topics: Antimetabolites; Azaguanine; Culture Techniques; DNA; HeLa Cells; Leucine; Protein Biosynthesis; RNA; RNA, Messenger; Ribosomes; Thymidine; Uridine
PubMed: 5835693
DOI: No ID Found -
Cancer Research Feb 1953
Topics: Amidohydrolases; Azaguanine; Brain; Deamination; Glioblastoma; Humans
PubMed: 13042801
DOI: No ID Found -
Life Sciences May 1977
Topics: Azaguanine; Liposomes; Mercaptopurine; Pharmaceutical Vehicles; Phosphatidylcholines; Solubility; Vitamin B 12
PubMed: 875619
DOI: 10.1016/0024-3205(77)90349-6 -
Journal of Cellular and Comparative... Oct 1962
Topics: Animals; Antineoplastic Agents; Azaguanine; Fluorouracil; Leukemia; Leukemia, Lymphoid; Lymphoma; Methotrexate; Mice; Nucleotides; Pyrimidines
PubMed: 13974703
DOI: 10.1002/jcp.1030600202 -
Proceedings of the National Academy of... Jun 1963
Topics: Azaguanine; Cyanides; Learning; RNA; Ristocetin
PubMed: 14019945
DOI: 10.1073/pnas.49.6.918 -
Archives of Biochemistry Nov 1950
Topics: Azaguanine; Deamination; Enzymes; Guanine; Guanine Deaminase
PubMed: 14790800
DOI: No ID Found