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British Journal of Clinical Pharmacology Jan 1982
Topics: Animals; Blood Pressure; Carbonic Anhydrase Inhibitors; Chlorothiazide; Dogs; History, 20th Century; Humans; Hypertension; Natriuresis; Rats; Structure-Activity Relationship
PubMed: 7066152
DOI: 10.1111/j.1365-2125.1982.tb01332.x -
American Heart Journal Feb 1960
Topics: Chlorothiazide; Humans; Hypertension
PubMed: 14399940
DOI: 10.1016/0002-8703(60)90288-x -
Journal of the Indian Medical... Aug 1959
Topics: Chlorothiazide; Humans
PubMed: 13857248
DOI: No ID Found -
Neonatal Network : NN Oct 1993
Topics: Bronchopulmonary Dysplasia; Calcium; Chlorothiazide; Humans; Infant, Newborn; Nephrocalcinosis
PubMed: 8413153
DOI: No ID Found -
American Journal of Health-system... Aug 2015The stability of a solution of chlorothiazide injection diluted with sterile water and stored in polypropylene syringes under refrigerated conditions was investigated.
PURPOSE
The stability of a solution of chlorothiazide injection diluted with sterile water and stored in polypropylene syringes under refrigerated conditions was investigated.
METHODS
Chlorothiazide solutions were compounded by adding 20 mL of sterile water for injection to a 500-mg vial of chlorothiazide sodium for injection. Six batches of chlorothiazide solution (25 mg/mL) were compounded; 0.5-mL portions were transferred to 1-mL polypropylene syringes, which were sealed with a Luer tip cap and stored at refrigeration temperatures (2-8 °C) protected from light. Three batches were potency tested by stability-indicating high-performance liquid chromatography (HPLC) assay using a 0.5-mL sample from each batch at designated time points. Visual and pH testing were performed using the three remaining batches; the contents of two syringes per batch were combined and visually inspected for container integrity and solution color and clarity, with duplicate pH testing performed at each time point.
RESULTS
HPLC analyses showed that the remaining percentage of the initial chlorothiazide content declined at an average daily rate of 1.4%, decreasing to 93% by day 6. All samples remained intact, clear, and colorless, with no visible particulate matter or precipitation observed throughout the study period. For all samples of chlorothiazide solution, pH values remained within the range of 9.2-10.0 throughout the 10-day study period.
CONCLUSION
When packaged in 1-mL polypropylene syringes and stored protected from light at refrigerated conditions, a solution of chlorothiazide sodium injection in water was stable for six days.
Topics: Antihypertensive Agents; Chlorothiazide; Chromatography, High Pressure Liquid; Drug Stability; Drug Storage; Humans; Polypropylenes; Syringes
PubMed: 26195655
DOI: 10.2146/ajhp140660 -
Lille Medical : Journal de La Faculte... Apr 1960
Topics: Chlorothiazide; Hydrochlorothiazide
PubMed: 13857580
DOI: No ID Found -
Lekarska Veda V Zahranici Mar 1960
Topics: Chlorothiazide; Diuretics
PubMed: 13856239
DOI: No ID Found -
Lancet (London, England) Jun 1959
Topics: Acetazolamide; Chlorothiazide; Hydrochlorothiazide
PubMed: 13666019
DOI: 10.1016/s0140-6736(59)90896-7 -
The New England Journal of Medicine Oct 1961
Topics: Chlorothiazide; Humans; Pancreas
PubMed: 13695602
DOI: 10.1056/NEJM196110052651403 -
British Medical Journal Feb 1960
Topics: Chlorothiazide; Disease Management; Hydrochlorothiazide; Hypertension
PubMed: 13831829
DOI: 10.1136/bmj.1.5172.515