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Japanese Journal of Medicine 1990Danazol was administered to two patients with paroxysmal nocturnal hemoglobinuria (PNH) with a dramatic effect on the hematological findings. The patients, 31- and...
Danazol was administered to two patients with paroxysmal nocturnal hemoglobinuria (PNH) with a dramatic effect on the hematological findings. The patients, 31- and 41-year-old females, were initially diagnosed as having aplastic anemia, and were initially treated with anabolic steroid and immunosuppressive therapy, respectively. Sugar water and Ham tests turned positive at the start of danazol therapy in the former patient and after two months in the latter patient. This drug produced a dramatic improvement in the hemoglobin level and the platelet count and showed few side effects in the patients. A possible mechanism of action of danazol for PNH is briefly discussed.
Topics: Adult; Blood Cell Count; Danazol; Female; Hemoglobinuria; Humans
PubMed: 2273626
DOI: 10.2169/internalmedicine1962.29.417 -
American Journal of Hematology Nov 2002Thrombocytopenia is a poor prognostic indicator in the myelodysplastic syndromes (MDS). Treatment options for patients with symptomatic thrombocytopenia are limited....
Thrombocytopenia is a poor prognostic indicator in the myelodysplastic syndromes (MDS). Treatment options for patients with symptomatic thrombocytopenia are limited. Danazol, an attenuated androgen, may have some efficacy in increasing the platelet count of patients with MDS. We retrospectively reviewed 33 patients with primary MDS who were treated with danazol for 6 or more weeks. After 6 weeks on danazol, the mean platelet count increased from 42 x 10(9)/L to 60 x 10(9)/L (P < 0.015), and 25 out of 33 patients (76%) had an increase in their platelet counts. Following 12 weeks of treatment, the mean platelet count increased to 67 x 10(9)/L (P < 0.005), and 21 out of 29 patients (72%) had an increase in their platelet counts. Seven out of nine patients no longer required platelet transfusions because bleeding stopped after 6 weeks on danazol. Mean duration of response was 10 months (range 2-68 months). Responses were seen in all French-American-British (FAB) subtypes and in all International Prognostic Scoring System (IPSS) scores. Therapy was well tolerated. Danazol may be effective in MDS patients who are thrombocytopenic.
Topics: Adult; Aged; Aged, 80 and over; Androgens; Danazol; Female; Humans; Male; Middle Aged; Myelodysplastic Syndromes; Platelet Count; Retrospective Studies; Thrombocytopenia; Time Factors
PubMed: 12410570
DOI: 10.1002/ajh.10209 -
The Australian & New Zealand Journal of... May 1980Danazol is being increasingly used for the treatment of a wide range of disorders, many of which appear to bear little relation to the condition for which the drug was... (Review)
Review
Danazol is being increasingly used for the treatment of a wide range of disorders, many of which appear to bear little relation to the condition for which the drug was originally marketed--endometriosis. It has been claimed that this drug acts by means of its antigonadotrophic effects on the pituitary; however, a review of the literature reveals that its efficacy in suppressing normal endometrial growth and in causing atrophy of deposits of endometrium cannot be explained solely on this basis. Recent information indicates that, besides acting at the pituitary level, a major mechanism of action may be by a direct inhibitory effect on target tissue. It is sugggested that such a mechanism would more readily account for the diverse effects of this drug in the treatment of many disorders, all of which appear to be associated with an imbalanced sensitivity of target organs to steroid hormones. A greater understanding of its mechanism of action could lead to an even wider application of this novel drug.
Topics: Danazol; Endometriosis; Female; Gonadotropins, Pituitary; Humans; Pregnadienes; Receptors, Steroid; Steroids; Uterine Neoplasms
PubMed: 6998453
DOI: 10.1111/j.1479-828x.1980.tb00107.x -
JAMA Aug 1985
Topics: Adult; Aminocaproic Acid; Danazol; Fibrinolysis; Hemophilia A; Hemophilia B; Humans; Male; Pregnadienes
PubMed: 4009909
DOI: No ID Found -
Fertility and Sterility Apr 1979
Topics: Animals; Danazol; Endometrial Hyperplasia; Endometrium; Female; Humans; Pregnadienes; Rabbits; Receptors, Estrogen
PubMed: 428596
DOI: No ID Found -
JAMA Jan 1976
Topics: Danazol; Endometriosis; Female; Humans; Pregnadienes
PubMed: 946036
DOI: 10.1001/jama.235.3.250b -
Drugs May 1980
Topics: Danazol; Gynecomastia; Hormones; Humans; Male; Pregnadienes
PubMed: 7389586
DOI: 10.2165/00003495-198019050-00005 -
Drugs May 1980
Topics: Antifibrinolytic Agents; Blood Coagulation; Danazol; Female; Humans; Menorrhagia; Menstruation; Pregnadienes; Prostaglandin Antagonists; Steroids
PubMed: 7389585
DOI: 10.2165/00003495-198019050-00003 -
FASEB Journal : Official Publication of... Feb 1989Danazol, an attenuated androgen, is useful in endometriosis, idiopathic thrombocytopenic purpura (ITP), and autoimmune hemolytic anemia (AIHA). However, its mechanism of...
Danazol, an attenuated androgen, is useful in endometriosis, idiopathic thrombocytopenic purpura (ITP), and autoimmune hemolytic anemia (AIHA). However, its mechanism of action is unknown. We investigated the possibility that danazol affects cell membranes directly. Red cell osmotic fragility was studied in patients receiving danazol. A significant decrease in osmotic fragility was observed. Accompanying the change, peripheral blood smears showed many target cells and electron microscopy revealed extra folds in erythrocyte membranes. Twenty-two patients were studied prospectively before and after danazol. Osmotic fragility decreased significantly (P less than 0.001) in 1 month of therapy and progressed with further treatment. A rebound increase (P less than 0.01) was observed in 1 month after discontinuation of danazol among 16 patients. Incubation experiments showed that danazol-induced changes are not reversed with normal sera. Patient sera did not induce the changes in normal red cells. Danazol in vitro protected red cells from osmotic lysis at low concentrations but enhanced lysis at high concentrations. We suggest that danazol alters red cell membranes directly to increase their surface area, inducing target cell formation and increasing their resistance to osmotic lysis.
Topics: Danazol; Erythrocyte Membrane; Humans; In Vitro Techniques; Osmotic Fragility; Pregnadienes; Prospective Studies
PubMed: 2914627
DOI: 10.1096/fasebj.3.2.2914627 -
The Ceylon Medical Journal Mar 1982
Topics: Adult; Danazol; Endometriosis; Female; Humans; Pelvic Neoplasms; Pregnadienes
PubMed: 7151242
DOI: No ID Found