-
The British Journal of Dermatology Aug 1995Twenty-seven patients with severe alopecia areata were treated with dapsone. The results of a mean treatment duration of 10 +/- 0.5 months are reported, and compared... (Clinical Trial)
Clinical Trial Comparative Study
Twenty-seven patients with severe alopecia areata were treated with dapsone. The results of a mean treatment duration of 10 +/- 0.5 months are reported, and compared with the results of long-term topical immunotherapy obtained previously at the same institute. The efficacy of dapsone proved to be markedly inferior to that of topical immunotherapy. The percentage of patients showing regrowth of hair during treatment with dapsone was comparable with the occurrence of spontaneous regrowth of hair reported in the literature.
Topics: Adult; Alopecia Areata; Dapsone; Female; Humans; Immunotherapy; Male; Middle Aged
PubMed: 7547397
DOI: 10.1111/j.1365-2133.1995.tb02628.x -
Journal of Drugs in Dermatology : JDD May 2010Topical dapsone gel 5% is indicated for the treatment of acne vulgaris and has been marketed since late 2008. The topical formulation retains the anti-inflammatory...
Topical dapsone gel 5% is indicated for the treatment of acne vulgaris and has been marketed since late 2008. The topical formulation retains the anti-inflammatory benefits of dapsone while minimizing the risk of toxicity associated with systemic exposure. This review summarizes the pharmacokinetic and safety data of topical dapsone gel 5% in acne patients, including those with glucose-6-phosphate dehydrogenase (G6PD) deficiency, and provides support for dapsone usage in sulfonamide-allergic patients. Overall, topical dapsone gel has a favorable short- and long-term safety profile and has been shown to have no risk of hemolytic anemia, including in G6PD deficient patients. Although there are some structural similarities between dapsone and sulfonamides, dapsone is not a sulfonamide and cross-reaction with sulfonamides has not been demonstrated.
Topics: Acne Vulgaris; Administration, Cutaneous; Clinical Trials as Topic; Dapsone; Dermatologic Agents; Drug Hypersensitivity; Gels; Glycogen Storage Disease Type I; Humans; Sulfonamides
PubMed: 20480797
DOI: No ID Found -
Journal of Drugs in Dermatology : JDD Oct 2007Dapsone gel 5%, a topical formulation of dapsone, was shown to deliver clinically effective doses of dapsone with minimal systemic absorption in 2 randomized,... (Randomized Controlled Trial)
Randomized Controlled Trial
Dapsone gel 5%, a topical formulation of dapsone, was shown to deliver clinically effective doses of dapsone with minimal systemic absorption in 2 randomized, vehicle-controlled, 12-week studies of patients with acne vulgaris. A 12-month, open-label, long-term safety study further evaluated the safety and efficacy of dapsone gel. Patients at least 12 years of age with acne vulgaris (N = 486) applied dapsone gel twice daily for up to 12 months. Application site reactions related to treatment were reported in 8.2% of the patients and were mostly mild to moderate in severity. Common nonapplication site adverse events included headache (20%) and nasopharyngitis (15%). No significant changes in hematology or blood chemistry parameters were observed. At one month, mean reduction from baseline in inflammatory lesion counts was 30.6%. At 12 months, mean reduction from baseline was 58.2%, 19.5%, and 49.0% for inflammatory, noninflammatory, and total lesion counts, respectively, (all P=.002 compared to baseline). These results show that dapsone gel 5% is safe and effective for long-term treatment of acne vulgaris and has a rapid onset of action.
Topics: Acne Vulgaris; Adolescent; Adult; Aged; Anti-Infective Agents; Child; Dapsone; Female; Gels; Humans; Male; Middle Aged; Treatment Outcome
PubMed: 17966175
DOI: No ID Found -
Leprosy Review Sep 1983
Topics: Animals; Dapsone; Drug Resistance, Microbial; Humans; Leprosy; Mice; Mycobacterium leprae
PubMed: 6355726
DOI: 10.5935/0305-7518.19830031 -
Indian Journal of Dermatology,... 2006
Topics: Acute Disease; Adult; Dapsone; Female; Humans; Leprostatic Agents; Leprosy; Myopia
PubMed: 17179626
DOI: 10.4103/0378-6323.29347 -
Journal of the Indian Medical... May 1989
Topics: Adult; Dapsone; Female; Humans; Leprosy; Psychoses, Substance-Induced
PubMed: 2600436
DOI: No ID Found -
Polimery W Medycynie 2024Dapsone (DAP) is an anti-inflammatory and antimicrobial active pharmaceutical ingredient used to treat, e.g., AIDS-related diseases. However, low solubility is a feature...
BACKGROUND
Dapsone (DAP) is an anti-inflammatory and antimicrobial active pharmaceutical ingredient used to treat, e.g., AIDS-related diseases. However, low solubility is a feature hampering its efficient use.
OBJECTIVES
First, deep eutectic solvents (DES) were used as solubilizing agents for DAP as an alternative to traditional solvents. Second, intermolecular interactions in the systems were described and quantified. Finally, the solubility prediction model, previously created using the machine learning protocol, was extended and improved using new data obtained for eutectic systems.
MATERIAL AND METHODS
New DES were created by blending choline chloride (ChCl) with 6 selected polyols. The solubility of DAP in these solvents was measured spectrophotometrically. The impact of water dilution on the solubility curve was investigated. Experimental research was enriched with theoretical interpretations of intermolecular interactions, identifying the most probable pairs in the systems. Dapsone self-association and its ability to interact with components of the analyzed systems were considered. Thermodynamic characteristics of pairs were utilized as molecular descriptors in the machine learning process, predicting solubility in both traditional organic solvents and the newly designed DES.
RESULTS
The newly formulated solvents demonstrated significantly higher efficiency compared to traditional organic solvents, and a small addition of water increased solubility, indicating its role as a co-solvent. The interpretation of the mechanism of DAP solubility highlighted the competitive nature of self-association and pair formation. Thermodynamic parameters characterizing affinity were instrumental in developing an efficient model for theoretical screening across diverse solvent classes. The study emphasized the necessity of retraining models when introducing new experimental data, as exemplified by enriching the model with data from DES.
CONCLUSIONS
The research showcased the efficacy of developing new DES for enhancing solubility and creating environmentally and pharmaceutically viable systems, using DAP as an example. Molecular interactions proved valuable in understanding solubility mechanisms and formulating predictive models through machine learning processes.
Topics: Solubility; Dapsone; Machine Learning; Deep Eutectic Solvents; Thermodynamics; Solvents
PubMed: 38197603
DOI: 10.17219/pim/177235 -
Journal of Pharmaceutical and... Dec 2001The electrochemical oxidation and adsorption of dapsone, an anti-leprotic drug were studied in aqueous alcohol medium at a stationary glassy carbon electrode. Cyclic...
The electrochemical oxidation and adsorption of dapsone, an anti-leprotic drug were studied in aqueous alcohol medium at a stationary glassy carbon electrode. Cyclic voltammetry studies showed one well-defined oxidation peak in the potential range 1.2-1.9 V at pH conditions 1.0, 4.0, 7.0, 9.2 and 13.0. The oxidation was irreversible and exhibited diffusion controlled adsorption. Controlled potential coulometry revealed one electron oxidation of the amino group in the molecule. A systematic study of the experimental parameters that affect the squarewave stripping response was carried out and the optimized experimental conditions were arrived at. A calibration plot was derived for the determination of the compound in solution. This method was used for the determination of dapsone in tablets and urine. The limits of determination was 0.0036 and 3.56 mg/ml and the relative standard deviation (n=10) was 4 ppt (0.4%) at a concentration level 0.100 mg/ml.
Topics: Dapsone; Electrochemistry; Humans; Hydrogen-Ion Concentration; Indicators and Reagents; Leprostatic Agents; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Tablets
PubMed: 11600299
DOI: 10.1016/s0731-7085(01)00480-0 -
Harefuah Jun 1982
Topics: Dapsone; Humans; Skin Diseases
PubMed: 7160696
DOI: No ID Found -
Der Hautarzt; Zeitschrift Fur... Apr 1997We report on two patients with granulomatous rosacea and another patient with granulomatous perioral dermatitis who responded well to dapsone. Dapsone has a...
We report on two patients with granulomatous rosacea and another patient with granulomatous perioral dermatitis who responded well to dapsone. Dapsone has a pharmacological double function as both an antibiotic and an antiphlogistic drug. Before the introduction of isotretinoin, dapsone had its place in the treatment of severe acne. To date, its use in granulomatous rosacea has not been described. When hematologic parameters are monitored, dapsone is considered a safe and cost-effective drug, especially in countries where isotretinoin is not readily available. However, the definite value of dapsone in granulomatous rosacea should be established by a controlled study.
Topics: Adult; Anti-Infective Agents; Biopsy; Dapsone; Facial Dermatoses; Female; Humans; Male; Middle Aged; Rosacea; Skin
PubMed: 9206712
DOI: 10.1007/s001050050577