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Advances in Biotechnological Processes 1984
Review
Topics: Culture Media; Daunorubicin; Fermentation; Humans; Indicators and Reagents; Neoplasms; Species Specificity; Streptomyces
PubMed: 6399841
DOI: No ID Found -
Acta Poloniae Pharmaceutica 2014The influence of temperature and relative air humidity on the stability of two novel derivatives of daunorubicin: [(N-piperidine)methylene]daunorubicin hydrochloride and...
The influence of temperature and relative air humidity on the stability of two novel derivatives of daunorubicin: [(N-piperidine)methylene]daunorubicin hydrochloride and [(N-pyrrolidine)methylene]daunorubicin hydrochloride was investigated. The process of degradation was studied by using high-performance liquid chromatography with ultraviolet (UV) detection. The kinetic and thermodynamic parameters of degradation were calculated.
Topics: Antibiotics, Antineoplastic; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Daunorubicin; Drug Stability; Humidity; Kinetics; Spectrophotometry, Ultraviolet; Technology, Pharmaceutical; Temperature
PubMed: 25265823
DOI: No ID Found -
Bioactive Materials Jun 2017Daunorubicin hydrochloride is a cell-cycle non-specific antitumor drug with a high therapeutic effect. The present study outlines the fabrication of daunorubicin...
Daunorubicin hydrochloride is a cell-cycle non-specific antitumor drug with a high therapeutic effect. The present study outlines the fabrication of daunorubicin hydrochloride-loaded poly (ε-caprolactone) (PCL) fibrous membranes by melt electrospinning for potential application in localized tumor therapy. The diameters of the drug-loaded fibers prepared with varying concentrations of daunorubicin hydrochloride (1, 5, and 10 wt%) were 2.48 ± 1.25, 2.51 ± 0.78, and 2.49 ± 1.58 μm, respectively. Fluorescence images indicated that the hydrophobic drug was dispersed in the hydrophilic PCL fibers in their aggregated state. The drug release profiles of the drug-loaded PCL melt electrospun fibrous membranes were approximately linear, with slow release rates and long-term release periods, and no observed burst release. The MTT assay was used to examine the cytotoxic effect of the released daunorubicin hydrochloride on HeLa and glioma cells (U87) . The inhibition ratios of HeLa and glioma cells following treatment with membranes prepared with 1, 5, and 10 wt% daunorubicin hydrochloride were 62.69%, 76.12%, and 85.07% and 62.50%, 77.27%, and 84.66%, respectively. Therefore, PCL melt electrospun fibrous membranes loaded with daunorubicin hydrochloride may be used in the local administration of oncotherapy.
PubMed: 29744416
DOI: 10.1016/j.bioactmat.2017.03.003 -
The Medical Letter on Drugs and... Apr 1980
Clinical Trial
Topics: Bone Marrow; Clinical Trials as Topic; Daunorubicin; Heart Diseases; Humans; Leukemia
PubMed: 6988689
DOI: No ID Found -
Lancet (London, England) Feb 1976
Topics: Aged; Daunorubicin; Heart; Heart Diseases; Humans; Male; Middle Aged
PubMed: 55702
DOI: 10.1016/s0140-6736(76)90275-0 -
TheScientificWorldJournal 2014The influence of pH and temperature on the stability of N-[(piperidine)methylene]daunorubicin hydrochloride (PPD) was investigated. Degradation was studied using an HPLC...
The influence of pH and temperature on the stability of N-[(piperidine)methylene]daunorubicin Hydrochloride and a comparison of the stability of daunorubicin and its four new amidine derivatives in aqueous solutions.
The influence of pH and temperature on the stability of N-[(piperidine)methylene]daunorubicin hydrochloride (PPD) was investigated. Degradation was studied using an HPLC method. Specific acid-base catalysis of PPD involves hydrolysis of protonated molecules of PPD catalyzed by hydrogen ions and spontaneous hydrolysis under the influence of water zwitterions, unprotonated molecules, and monoanions of PPD. The thermodynamic parameters of these reactions, energy, enthalpy, and entropy, were calculated. Also, the stability of daunorubicin and its new amidine derivatives (piperidine, morpholine, pyrrolidine, and hexahydroazepin-1-yl) in aqueous solutions was compared and discussed.
Topics: Daunorubicin; Hydrogen-Ion Concentration; Hydrolysis; Temperature
PubMed: 24688433
DOI: 10.1155/2014/803789 -
Drug Development and Industrial Pharmacy Aug 2012The stability of N-[(morpholine)methylene]-daunorubicin hydrochloride (MMD) was investigated in the pH range 0.44-13.54, at 313, 308, 303 and 298 K. The degradation of...
The stability of N-[(morpholine)methylene]-daunorubicin hydrochloride (MMD) was investigated in the pH range 0.44-13.54, at 313, 308, 303 and 298 K. The degradation of MMD as a result of hydrolysis is a pseudo-first-order reaction described by the following equation: ln c = ln c(0) - k(obs)• t. In the solutions of hydrochloric acid, sodium hydroxide, borate, acetate and phosphate buffers, k(obs) = k(pH) because general acid-base catalysis was not observed. Specific acid-base catalysis of MMD comprises the following reactions: hydrolysis of the protonated molecules of MMD catalyzed by hydrogen ions (k(1)) and spontaneous hydrolysis of MMD molecules other than the protonated ones (k(2)) under the influence of water. The total rate of the reaction is equal to the sum of partial reactions: k(pH) = k(1) • a(H)+ • f(1) + k(2) • f(2) where: k(1) is the second-order rate constant (mol(-1) l s(-1)) of the specific hydrogen ion-catalyzed degradation of the protonated molecules of MMD; k(2) is the pseudo-first-order rate constant (s(-1)) of the water-catalyzed degradation of MMD molecules other than the protonated ones, f(1) - f(2) are fractions of the compound. MMD is the most stable at approx. pH 2.5.
Topics: Acid-Base Equilibrium; Buffers; Catalysis; Daunorubicin; Drug Stability; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Morpholines; Protons; Solutions; Temperature; Water
PubMed: 22124459
DOI: 10.3109/03639045.2011.637053 -
Acta Poloniae Pharmaceutica 2011The influence of temperature and relative air humidity on the stability of the novel derivative of daunorubicin: [(N-morpholine)metylene]daunorubicin hydrochloride was...
The influence of temperature and relative air humidity on the stability of the novel derivative of daunorubicin: [(N-morpholine)metylene]daunorubicin hydrochloride was investigated. The process of degradation was studied by using high-performance liquid chromatography with ultraviolet (UV) detection. In dry air, the degradation of [(N-morpholine)metylene]daunorubicin hydrochloride was a first-order reaction depending on the substrate concentration, while at relative air humidity from 60.5 to 90.0% it was an autocatalytic reaction of the first order with respect to MMD concentration. The kinetic and thermodynamic parameters of degradation were calculated.
Topics: Antibiotics, Antineoplastic; Chromatography, High Pressure Liquid; Daunorubicin; Humidity; Morpholines; Particle Size; Temperature; Thermodynamics
PubMed: 21928722
DOI: No ID Found -
Cancer Treatment Reports 1981The authors summarize the early studies on the isolation, structure determination, biological effects, and mechanism of action of daunorubicin (DNR). In fact, the... (Comparative Study)
Comparative Study
The authors summarize the early studies on the isolation, structure determination, biological effects, and mechanism of action of daunorubicin (DNR). In fact, the relationship between affinity for DNA and biological activity was first recorded for DNR and later confirmed on several DNA analogs, both biosynthetic and semisynthetic. A possible divergence was eventually observed with 4-methoxy-DNR. This compound is as active as DNR on the DNA synthesis but eight times more potent on different experimental tumor systems. In this context, it is worth noting that recent data on the N-acetyl derivatives of DNR and doxorubicin indicated the persistence of some activity on P388 leukemia in spite of their strongly reduced affinity for DNA and cytotoxic activity when compared with the parent compounds.
Topics: Animals; Chemistry; DNA; Daunorubicin; Doxorubicin; History, 20th Century; Idarubicin; Italy; Mice; Neoplasms, Experimental; Rats; Stereoisomerism
PubMed: 7049379
DOI: No ID Found -
Biochimie May 1984Daunorubicin and doxorubicin, two antibiotics belonging to the anthracycline group, are widely used in human cancer chemotherapy. Their activity has been attributed... (Review)
Review
Daunorubicin and doxorubicin, two antibiotics belonging to the anthracycline group, are widely used in human cancer chemotherapy. Their activity has been attributed mainly to their intercalation between the base pairs of native DNA. Complex formation between daunorubicin or doxorubicin with polydeoxyribonucleotides and DNAs of various base composition or chromatins has been investigated by numerous techniques. Many authors have tried to correlate biological and therapeutic activities with the affinity of the drugs for DNA or some specific sequences of DNA. In vivo these anthracycline drugs cause DNA damage such as fragmentation and single-strand breaks. The mechanism of action of anthracyclines involves the inhibition of RNA and DNA syntheses. There exists two limiting factors in the use of anthracyclines as antitumoral agents: a chronic or acute cardiotoxicity and a spontaneous or acquired resistance. In both cases, there is probably an action at the membrane level. It has to be noted that daunorubicin and doxorubicin have a particular affinity for phospholipids and that the development of resistance is linked to some membrane alterations.
Topics: Animals; Chemical Phenomena; Chemistry; DNA; DNA Replication; Daunorubicin; Doxorubicin; Heart; Humans; Molecular Conformation; Nucleic Acid Denaturation; Structure-Activity Relationship; Transcription, Genetic
PubMed: 6380596
DOI: 10.1016/0300-9084(84)90018-x