-
AJP Reports Oct 2019Deciduosis is the presence of ectopic decidual tissue outside the uterus, pelvic, or abdominal organs usually associated with pregnancy. It usually presents as smaller...
Deciduosis is the presence of ectopic decidual tissue outside the uterus, pelvic, or abdominal organs usually associated with pregnancy. It usually presents as smaller lesions but can be larger vascular lesions. Typically, these masses are detected incidentally during operative procedures. Our patient was referred at 14 weeks for a large intrauterine mass detected on ultrasound examination that was initially thought to be an acardiac twin. The mass was highly vascularized. However, since the patient was asymptomatic, she strongly desired to continue the pregnancy. The pregnancy was followed closely from 14 to 39 weeks with serial ultrasound examinations. The vascularity was documented to diminish overtime and the mass appeared to convolute as well. Due to the decrease in vascularity of the mass, the patient was allowed spontaneous vaginal delivery at term. Following delivery of the fetus and the placenta, the mass was easily extracted manually without any complications.
PubMed: 31737406
DOI: 10.1055/s-0039-1697647 -
The Indian Medical Gazette Feb 1896
PubMed: 29002515
DOI: No ID Found -
Biology of Reproduction Aug 1982The role of mast cells in deciduoma formation in the uterus of mice was investigated by using genetically mast cell-deficient (WB x C57BL/6)F1-W/Wv (hereafter called...
The role of mast cells in deciduoma formation in the uterus of mice was investigated by using genetically mast cell-deficient (WB x C57BL/6)F1-W/Wv (hereafter called WBB6F1-W/Wv) mice. Deciduoma formation occurred in castrated WBB6F1-W/Wv mice after estradiol-progesterone injection and traumatization in spite of their deficiency of mast cells. Injection of diphenhydramine, which blocks histamine receptors, inhibited deciduoma formation in WBB6F1-W/Wv mice as well as in congenic +/+ mice. THe uterus of WBB6F1-W/Wv mice contained about 10% of the amount of histamine found in the uterus of +/+ mice. These results suggest that mast cells are not essential for formation of deciduomata and that histamine originating from sources other than mast cells may be important in deciduoma formation.
Topics: Animals; Castration; Decidua; Diphenhydramine; Estradiol; Female; Mast Cells; Mice; Mice, Inbred Strains; Organ Size; Pregnancy; Progesterone; Uterus
PubMed: 7115851
DOI: 10.1095/biolreprod27.1.25 -
Biology of Reproduction Dec 1978
Topics: Animals; Endometrial Hyperplasia; Endometrium; Estradiol; Estrus; Female; Guinea Pigs; Pregnancy; Progesterone; Uterus
PubMed: 570434
DOI: 10.1095/biolreprod19.5.1135 -
Biology of Reproduction Sep 1982Adult female rats which had been ovariectomized on Day 1, 5, 10 or 20 of age invariably formed deciduomata in response to uterine trauma or an intraluminal...
Adult female rats which had been ovariectomized on Day 1, 5, 10 or 20 of age invariably formed deciduomata in response to uterine trauma or an intraluminal oil-instillation given after injections of estradiol-17 beta for 3 days from Day 60 onward followed by daily injections of progesterone starting 2 days later. If the magnitude of the deciduomal response was estimated by the decidual cell reaction index, the responses were larger in these rats than in the animals ovariectomized as adults. Two groups of rats ovariectomized on Days 1 and 10 were transplanted subcutaneously with one ovary on Day 10. When subjected to deciduogenic stimuli, after removal of the grafts on the first day of estrus occurring after Day 60 followed by hormonal sensitization of the endometrium, the 2 groups of rats elicited deciduomal responses approximately the same in magnitude. These findings indicate that the neonatal ovary has little effect on the development and differentiation of the rat uterus.
Topics: Aging; Animals; Castration; Decidua; Endometrium; Estradiol; Female; Ovary; Progesterone; Rats; Uterus
PubMed: 7126730
DOI: 10.1095/biolreprod27.2.308 -
Endocrinology May 1950
Topics: Deciduoma; Embryo Implantation; Endometrium; Estrogens; Female; Humans; Pregnancy
PubMed: 15414823
DOI: 10.1210/endo-46-5-489 -
Endocrinology May 1988The ability of ovarian steroid hormones to modulate experimentally induced decidual tissue (DT) growth and the associated changes in uterine blood flow rates (UBF) was...
The ability of ovarian steroid hormones to modulate experimentally induced decidual tissue (DT) growth and the associated changes in uterine blood flow rates (UBF) was examined in ovariectomized guinea pigs after uterine trauma (designated day 0 of the studies). Uteri that were exposed, but not manipulated, served as controls. Uterine and DT weights as well as UBF, rates, were subsequently recorded on either day 5 or 10 posttrauma. Oil treatment failed to induce an increase in either control or traumatized uterine weights between days 5 and 10, and trauma had no effect on UBF rates in either group. Daily progesterone (P; 2 mg) treatment induced a significant elevation in DT weight by day 10 and elevated UBF rates between days 5 and 10 relative to control values. Daily P treatment augmented by estradiol (E2; 1 microgram) therapy on days 0 and 1 induced a significant increase in DT weights and UBF rates between days 5 and 10 in both control and DT groups relative to those in oil-treated animals. Combined P and E2 (P/E2) treatment induced a moderate increase in DT weight by day 10 posttrauma and elevated UBF rates in both control and DT groups. Acute treatment (i.e. days -3 to 0) with these steroid regimens indicated that neither P nor P/E2 treatment maintained DT growth. However, day -3 to 0 treatment with P in combination with a single day 0 injection of E2 allowed for maximal DT growth by day 10 and maintained elevated UBF rates relative to control values. P/E2 treatment between days -3 and 0 also induced an increase in UBF rates in both control and DT uteri relative to those in oil-treated animals. These results indicate that E2 is essential for supporting the P-directed differentiation and proliferation of stimulated guinea pig endometrium into DT. The ability of decidualization to occur in the absence of chronic steroid support indicates that uterine sensitization for cellular differentiation in this species only requires that the endometrium be initially primed by ovarian steroid hormones, but that subsequent growth is autonomous.
Topics: Animals; Cell Differentiation; Decidua; Endometrium; Estradiol; Estrus; Female; Guinea Pigs; Organ Size; Ovariectomy; Pregnancy; Progesterone; Regional Blood Flow; Uterus
PubMed: 3359979
DOI: 10.1210/endo-122-5-2183 -
Biology of Reproduction Apr 1985The objective of this study was first, to identify the proteins associated with decidualization of the hamster uterus by comparing the protein maps of decidualized and...
The objective of this study was first, to identify the proteins associated with decidualization of the hamster uterus by comparing the protein maps of decidualized and nondecidualized endometrium in vivo, and second, to determine whether decidual cell cultures produced these characteristic proteins. Decidualization was induced in one uterine horn, and the contralateral horn was not stimulated (control tissue). Animals were ovariectomized and a subcutaneous progesterone implant was used to maintain decidualization. Uterine proteins from nuclear and cytosol fractions were analyzed by two-dimensional electrophoresis using a highly sensitive protein staining technique. Analysis of nuclear extract and cytosol from decidualized and nondecidualized endometrium from Days 6, 7, and 8 of pseudopregnancy demonstrated the presence of 11 nuclear and five cytosolic deciduoma-associated proteins. Serum and erythrocyte proteins were identified by two-dimensional electrophoresis, and none of the 16 deciduoma-associated proteins was a serum or erythrocyte contaminant. Forty-eight-hour cultures of decidual cells harvested from Day 5 of pseudopregnancy produced all 16 of the deciduoma-associated proteins found in whole tissue in situ. Culture conditions minimized serum and erthrocyte contamination, enhancing the detection of deciduomal cell proteins. Four nuclear and two cytosolic proteins were considered deciduoma specific, i.e., they were not associated with cellular proliferation, as evidenced by their absence from cultures of rapidly dividing fetal hamster fibroblasts. Thus, these studies show that the detection of deciduomal proteins may be a useful criterion for the assessment of decidualization in vitro and in vivo.
Topics: Animals; Cell Nucleus; Cells, Cultured; Cricetinae; Cytosol; Decidua; Electrophoresis; Female; Pregnancy; Proteins; Uterus
PubMed: 3995133
DOI: 10.1095/biolreprod32.3.631 -
Reproductive Toxicology (Elmsford, N.Y.) 2001Butadiene diepoxide (BDE), a reactive metabolite of 1,3-butadiene that is an important industrial chemical used in synthetic rubber production causes a dose-dependent...
Butadiene diepoxide (BDE), a reactive metabolite of 1,3-butadiene that is an important industrial chemical used in synthetic rubber production causes a dose-dependent inhibition of deciduoma development in pseudopregnant Sprague-Dawley rats. This study used 4 daily i.p. BDE doses of 0.20, 0.25, 0.30, 0.35, or 0.40 to characterize mechanisms that may be responsible for the antideciduoma effect. Pseudopregnant rats were treated either before (pseudopregnancy [PPG] days 1-4) or after (PPG days 5-9) deciduoma induction by endometrial trauma with a blunt needle. Animals were killed on PPG day 9 and evaluated for serum progesterone and endometrial protein and DNA. RT-PCR was used to measure message for estrogen receptor (ER) alpha and pituitary adenylate cyclase-activating polypeptide (PACAP). Substrate zymography and Western blotting were used respectively to measure matrix metalloproteinase (MMP)-9 and inducible nitric oxide synthase. The antideciduoma effects of BDE were associated with decreases in endometrial weight, protein, and DNA, with decreases in serum progesterone, and with decreases in PACAP message and MMP-9. A reduction in NOS was identified at the highest dose of BDE. Message for estrogen receptor (ER) alpha was not affected at any dose. We conclude that the reduction in decidual proliferation was direct and appeared to be associated with either 1) a decrease in the effectiveness of the deciduogenic stimulation and/or a weakened endometrial sensitivity to the stimulus; or 2) an effect on deciduoma development. Molecular mechanisms that apparently contributed to BDE inhibition of decidual metabolism included the synthesis of protein and DNA involved in decidual growth, the synthesis and activation of a matrix metalloproteinase for degradation of the extracellular matrix that is essential for tissue remodeling during deciduoma development, and the nitric oxide/nitric oxide synthase and pituitary adenylate cyclase-activating peptide systems that are involved in promoting vasodilation and increased vascular permeability to enhance the availability of substrates for maximal deciduoma growth. The ovotoxicity of BDE, which has previously been established, may indirectly affect decidual proliferation by reducing progesterone, the preeminent endocrine regulator of deciduoma development. The findings also suggest that BDE may possess no estrogenic action since it was associated with endometrial weight loss and unaltered levels of the estrogen receptor alpha mRNA expression.
Topics: Animals; Butadienes; Cell Division; DNA; DNA Primers; Decidua; Dose-Response Relationship, Drug; Estrogen Receptor alpha; Female; Injections, Intraperitoneal; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neuropeptides; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Organ Size; Pituitary Adenylate Cyclase-Activating Polypeptide; Pregnancy; Progesterone; Proteins; Pseudopregnancy; RNA, Messenger; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction
PubMed: 11390169
DOI: 10.1016/s0890-6238(01)00121-6 -
Reproductive Toxicology (Elmsford, N.Y.) 1989Female rats of the T strain were given single daily injections of 100 micrograms and 200 micrograms of tamoxifen (Tx) and MER-25 (MER) for 5 days beginning on the day of...
Female rats of the T strain were given single daily injections of 100 micrograms and 200 micrograms of tamoxifen (Tx) and MER-25 (MER) for 5 days beginning on the day of birth (DAY 1). When sacrificed on Day 60, the Tx-treated rats (Tx rats) exhibited continued vaginal diestrus, whereas the females given MER or the vehicle alone showed regular estrous cycles. Ovaries from Tx rats were polyfollicular without corpora lutea, while those from MER rats, as well as from the controls given the vehicle alone, invariably contained both follicles and corpora lutea. In Tx rats, the uteri underwent atrophy, containing few uterine glands in an endometrium largely occupied by fibroblasts. Decidual response of the uterus to intraluminal oil instillation was markedly reduced in Tx rats given an appropriate regimen of progesterone and estradiol injections following ovariectomy on Day 60. By contrast, MER given neonatally had little effects on decidualization. Since ovariectomy on Day 10 brought about no amelioration of the decidualization in Tx rats, it is suggested that the lowered deciduogenic responsiveness to the instillation was caused by a direct action of Tx on the uterus of neonatal rats rather than by a Tx-induced alteration of hypothalamo-hypophyseal-ovarian system. Differences in effect on the female reproductive system between Tx and MER were discussed.
Topics: Animals; Animals, Newborn; Decidua; Endometrium; Estradiol; Estrogen Antagonists; Estrus; Ethamoxytriphetol; Female; Ovariectomy; Rats; Tamoxifen; Uterus
PubMed: 2520524
DOI: 10.1016/0890-6238(89)90009-9