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Biology of Reproduction Aug 1974
Topics: Animals; Antigen-Antibody Reactions; Cross Reactions; Decidua; Epitopes; Female; Immune Sera; Immunodiffusion; Immunoelectrophoresis; Mice; Pregnancy; Rats; Uterine Neoplasms; Uterus
PubMed: 4141902
DOI: 10.1095/biolreprod11.1.50 -
The Journal of Veterinary Medical... Apr 1999Canine deciduoma could be induced in the diestrous uterus by an intrauterine inoculation of a culture suspension of E. coli originally isolated from naturally occurring...
Canine deciduoma could be induced in the diestrous uterus by an intrauterine inoculation of a culture suspension of E. coli originally isolated from naturally occurring canine pyometra. These deciduomas had the same histological findings as those of naturally occurring canine pyometra with so called "Swiss cheese endometrium". This suggests a possibility that the canine pyometra is a kind of naturally occurring decidual reaction (deciduoma) induced by one of several triggers such as bacterial infection.
Topics: Animals; Decidua; Dog Diseases; Dogs; Endometritis; Escherichia coli Infections; Female; Pregnancy
PubMed: 10342298
DOI: 10.1292/jvms.61.433 -
Journal of Reproduction and Fertility Jul 1986The intraluminal injection of oil produced deciduoma formation in ovariectomized, mast cell-normal (+/+) and mast cell-deficient (W/Wv) mice that were treated with...
The intraluminal injection of oil produced deciduoma formation in ovariectomized, mast cell-normal (+/+) and mast cell-deficient (W/Wv) mice that were treated with exogenous steroids. Oil injection and trauma (e.g. sutures) also produced a deciduoma in ovariectomized +/+ and W/Wv mice that had received a single control (+/+) ovary transplanted under the kidney capsule. After transfers of donor blastocysts, implantation and live births were obtained in +/+ and W/Wv mice containing a single ovary transplant. Our results demonstrate that uterine mast cells are not required for the production of a decidual cell response, implantation, gestation or the birth of live offspring in mice.
Topics: Animals; Decidua; Embryo Implantation; Embryo Transfer; Female; Mast Cells; Mice; Mice, Inbred Strains; Ovariectomy; Ovary; Pregnancy; Pseudopregnancy
PubMed: 3735243
DOI: 10.1530/jrf.0.0770471 -
The Journal of Veterinary Medical... Mar 1997The effect of ovariectomy in the early first half of the diestrus was examined on the induction or maintenance of suture-induced canine deciduoma. Ovariectomy...
The effect of ovariectomy in the early first half of the diestrus was examined on the induction or maintenance of suture-induced canine deciduoma. Ovariectomy immediately, or some days, after the insertion of suture had no effect on the induction or maintenance of deciduoma. Even when ovariectomy was performed within 4 days before insertion, deciduoma could be induced in spite of there being no ovary. However, when ovariectomy was done 4 or more days before suture insertion, the rate of deciduoma was decreased or no deciduoma was induced. These results indicate that the influence of the ovary on the endometrium may persist for at least 4 days after ovariectomy. Ovariectomy after the suture insertion had few effects. It is suggested that canine uterine glands in the early first half of the diestrus maintain a certain degree of self-proliferative ability even after ovariectomy, and thus canine deciduoma is not as dependent on the ovary that of the rodentia.
Topics: Animals; Body Weight; Cell Division; Decidua; Diestrus; Dogs; Female; Laparotomy; Ovariectomy; Ovary; Suture Techniques; Uterus
PubMed: 9101486
DOI: 10.1292/jvms.59.227 -
The Journal of Veterinary Medical... Mar 1997Bitches were examined to see whether canine deciduoma could be induced at some reproductive stages with the different conditions of corpora lutea by inserting a silk...
Bitches were examined to see whether canine deciduoma could be induced at some reproductive stages with the different conditions of corpora lutea by inserting a silk suture into the uterine lumen. The bitches stimulated in the early and middle stages of diestrus or in unilateral pregnancy corresponding to these diestrous stages formed deciduoma at a high induction rate, however, no difference in the strength of decidual reaction between the pregnant and diestrous stages was recognized. On the other hand, no reaction could be seen in bitches in late diestrus, the late stage of unilateral pregnancy or the post partum repair phase in which stromal decidual cells similar to those of the rodentia can be seen. In already implanted uteri, however, no deciduoma was formed in the interplacental areas. Even though the corpora lutea were functional, new additional stimulations were not accepted at the interplacental area in which the uterine horn had already been influenced by fertilized ova. From these results, it was suggested that in the dog as well as the rodentia, the endometrium has to be under the influence of functional corpora lutea in order to form deciduoma.
Topics: Animals; Cell Division; Corpus Luteum; Decidua; Dogs; Estrus; Female; Ovary; Pregnancy; Reproduction; Uterus
PubMed: 9101477
DOI: 10.1292/jvms.59.185 -
European Journal of Gynaecological... 1996
Topics: Colon; Decidua; Fallopian Tubes; Female; Humans; Middle Aged; Ovary; Parity; Pregnancy
PubMed: 8654471
DOI: No ID Found -
The American Journal of Pathology Dec 1988Two different hormonal regimens to induce pseudopregnancy resulted in a pronounced increase in the susceptibility of the murine uterus to intraluminal injections of...
Two different hormonal regimens to induce pseudopregnancy resulted in a pronounced increase in the susceptibility of the murine uterus to intraluminal injections of Listeria monocytogenes. Preimmunization, which profoundly augments systemic listeria resistance, had no effect on this increased uterine susceptibility. Anti-listerial responses in other organs were unaffected by pseudopregnancy. Animals manifesting increased susceptibility formed distinct uterine swellings in response to the combination of hormones and uterine listeria. These swellings correspond to previously described deciduoma and closely mimic the decidualized endometrium of pregnancy. The nature of the defective response to listeria was investigated by immunocytochemistry. Increased bacterial titers were correlated with an inability of macrophages and T lymphocytes to reach tissue listeria in discrete regions of deciduoma-bearing uteri. Control uteri showed a normal granulomatous pattern of inflammation. These findings closely parallel previous findings in the murine decidua basalis and suggest that properties of decidualized endometrial stromal cells regulate local immune responsiveness.
Topics: Animals; Decidua; Female; Immunoenzyme Techniques; Immunohistochemistry; Listeria monocytogenes; Listeriosis; Macrophages; Mice; Pseudopregnancy; T-Lymphocytes
PubMed: 3144175
DOI: No ID Found -
Indian Journal of Physiology and... Jan 2003An understanding of the cellular and molecular basis of blastocyst implantation in the human remains as yet a black box, however, a few experimental models using human... (Review)
Review
An understanding of the cellular and molecular basis of blastocyst implantation in the human remains as yet a black box, however, a few experimental models using human and non-human primate species have addressed this issue. This review attempts to highlight, based on experimental evidence, the paradigm shifts in our understanding of the endocrine basis of embryo implantation, and the nature of dialogue between a growing, viable conceptus and maternal endometrial cells in the establishment of 'receptivity' for blastocyst implantation. It is being proposed that an existing inflammation paradigm of blastocyst implantation could be tested using an experimental model to compare tissue behaviour of conceptus associated endometrial cells with that occurring after induction of deciduoma in hormone-primed uterus. We anticipate that an in vitro model of blastocyst implantation using the experimental models of homotypic and heterotypic cultures of uterine epithelial and stromal fibroblast cells expressing structural and functional phenotypic responses as observed in situ may provide us with necessary clues about the temporal and spatial nature of cellular and molecular functions involving various endocrine and paracrine factors at implantation.
Topics: Animals; Blastocyst; Embryo Implantation; Embryo, Mammalian; Endometrium; Female; Humans; Models, Biological
PubMed: 12708120
DOI: No ID Found -
Biology of Reproduction Aug 1983
Topics: Androgens; Animals; Castration; Decidua; Estrus; Female; Indomethacin; Organ Size; Pregnancy; Prostaglandins; Rats
PubMed: 6684487
DOI: 10.1095/biolreprod29.1.93 -
Endocrinologia Japonica Feb 1975When rats ovariectomized at 3 days of age and given a single injection of 1.25 mg testosterone propionate on the next day became 60 days old, they were given 3 daily...
When rats ovariectomized at 3 days of age and given a single injection of 1.25 mg testosterone propionate on the next day became 60 days old, they were given 3 daily injections of 0.2 mug estradiol-17 beta followed by 7 daily combined injections of 2 mg progesterone and 0.2 mug estradiol. Incidence of deciduomata in reaction to uterine trauma applied on the 4th day of the progesterone-estradiol injections was almost as high as that in neonatally ovariectomized, non-androgenized rats, but the response was significantly smaller in size in androgenized rats than in non-androgenized animals. If females similarly operated on were given injections of 0.1 mug estradiol for 30 days prior to 7 daily injections of progesterone-estradiol, deciduoma formation in androgenized rats was markedly reduced in both incidence and size of the response. In non-androgenized group, deciduoma formation was not significantly affected by chronic administration of estradiol.Accordingly, it is likely that, although androgen injected during neonatal life is responsible for the reduction of uterine responsiveness in androgen-sterilized rats (Takewaki and Ohta, 1974) continued exposure of the uterus to estrogen may play a co-operative role in the event.
Topics: Animals; Castration; Decidua; Estradiol; Female; Progesterone; Rats; Testosterone; Uterine Diseases; Vagina
PubMed: 1126325
DOI: 10.1507/endocrj1954.22.79