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Immunology and Allergy Clinics of North... May 2013Nonsteroidal anti-inflammatory drugs (NSAIDs) are cyclooxygenase inhibitors with analgesic, anti-inflammatory, antipyretic, and antithrombotic effects. NSAIDs have been... (Review)
Review
Nonsteroidal anti-inflammatory drugs (NSAIDs) are cyclooxygenase inhibitors with analgesic, anti-inflammatory, antipyretic, and antithrombotic effects. NSAIDs have been implicated in a variety of drug-induced reactions that are proved as or suspected of being mediated through a host immune response. Single-drug-induced reactions are the hallmark of these types of reactions. The types of single-drug-induced reactions are the confluence of 2 variables, the structure of the drug and the specific types of immune responses. This article identifies reactions patterns and the NSAIDs most likely to elicit each immune response.
Topics: Anaphylaxis; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Humans; Hypersensitivity, Delayed; Urticaria
PubMed: 23639711
DOI: 10.1016/j.iac.2012.12.002 -
British Medical Bulletin Jan 1967
Review
Topics: Adjuvants, Immunologic; Animals; Autoimmune Diseases; Guinea Pigs; Humans; Hypersensitivity, Delayed
PubMed: 5342377
DOI: 10.1093/oxfordjournals.bmb.a070514 -
Molecular Medicine Reports Jul 2016Ultraviolet (UV) radiation-induced immunosuppression leading to skin cancer has received increased attention in previous years. The present study aimed to investigate...
Ultraviolet (UV) radiation-induced immunosuppression leading to skin cancer has received increased attention in previous years. The present study aimed to investigate the immunoprotection offered by Anthelios sunscreen in a mouse model of Candida albicans‑induced delayed‑type hypersensitivity. Anthelios sunscreen was applied to the skin on the dorsal skin of BALB/c mice treated with a sub‑erythema dose of solar‑simulated radiation. Delayed‑type hypersensitivity was induced by immunization with Candida albicans. Changes in the skin thickness of the foot pads were measured, and immunosuppression rates were also evaluated. The expression levels of CD207, CD80 and CD86 in the Langerhans cells were semi‑quantitatively detected using Western blotting and immunohistochemical assays. The delayed‑type hypersensitivity mouse model was successfully established. The minimal erythema doses of UVA and UVB exposure to the mice were 2,000 and 145 mJ/cm2, respectively. The immunosuppression rates in the sunscreen group and non‑sunscreen group were 24.39 and 65.85%, respectively (P<0.01). The results of the Western blotting and immunohistochemistry showed that the expression levels of CD207 (P<0.01), CD80 (P<0.05) and CD86 (P<0.01) were higher in the sunscreen group, compared with those in the non‑sunscreen group. UV exposure reduced Candida albicans antigen‑induced delayed‑type hypersensitivity. Anthelios sunscreen was found to protect the skin from immunosuppression through the activation of epidermal Langerhans cells.
Topics: Animals; Antigens, CD; Biomarkers; Biopsy; Candida albicans; Disease Models, Animal; Dose-Response Relationship, Radiation; Hypersensitivity, Delayed; Immunization; Immunohistochemistry; Immunosuppression Therapy; Mice; Sunscreening Agents; Ultraviolet Rays
PubMed: 27175551
DOI: 10.3892/mmr.2016.5284 -
Journal of Medical and Veterinary... 1995The aim of this investigation was to study epidemiological aspects of paracoccidioidomycosis, the main endemic systemic mycosis in Brazil. This study was carried out...
The aim of this investigation was to study epidemiological aspects of paracoccidioidomycosis, the main endemic systemic mycosis in Brazil. This study was carried out using the paracoccidioidin delayed hypersensitivity test in 96 Latin American wild mammals, including 49 arboreal animals (primates): 33 Cebus apella (weeping-capuchin), 16 Callithrix jacchus (marmoset); and 47 terrestrial animals (carnivora): 37 Nasua nasua (coatimundi), and 10 Felidae [Panthera onca (jaguar), Felis paradalis (ocelot), Felis wiedii (margay), Felis tigrina (wild cat) and Felis geoffroyi (wild cat)], taking their behaviour and habitat into consideration. When the levels of paracoccidiodin positive reactions were examined, terrestrial animals showed significantly higher rates (82.98%) while arboreal animals showed lower reactivity (22.45%) (P < 0.01). The data are relevant because there are quite a few papers regarding domestic and wild animals and this study may help the understanding of some aspects of the parasite ecology. These results point to the soil as the most probable reservoir of Paracoccidioides brasiliensis, and this is possibly the ecological niche of the saprophytic phase in nature.
Topics: Animals; Carnivora; Female; Fungal Proteins; Hypersensitivity, Delayed; Latin America; Male; Paracoccidioidomycosis; Primates; Skin Tests
PubMed: 7650577
DOI: 10.1080/02681219580000081 -
Pediatric Annals Nov 1998
Review
Topics: Adolescent; Child; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Latex Hypersensitivity; Risk Factors
PubMed: 9826879
DOI: 10.3928/0090-4481-19981101-09 -
The Journal of Allergy and Clinical... 2015
Topics: Adult; Brain Injuries; Female; Humans; Hypersensitivity, Delayed; Intracranial Aneurysm; Nervous System Diseases; Nickel; Surgical Instruments
PubMed: 25783162
DOI: 10.1016/j.jaip.2015.02.004 -
Medical Microbiology and Immunology 1989Antigen A60 has been purified from the cytoplasm of Mycobacterium bovis BCG, and its composition has been determined: it has proved to be able to elicit immune reactions...
Antigen A60 has been purified from the cytoplasm of Mycobacterium bovis BCG, and its composition has been determined: it has proved to be able to elicit immune reactions of both humoral and cellular type. Inoculation of A60 into the footpad of mice previously sensitized with the same antigen, or with whole mycobacterial cells produced a footpad swelling showing a peak at 24 h. Similar delayed hypersensitivity reactions were induced in sensitized guinea-pigs by subcutaneous injection of an A60 dose of 0.01 micrograms (minimal revealing dose). A quantity thousandfold higher (15 micrograms A60) was unable to induce in unsensitized guinea pigs the mounting of a cellular immunisation against A60, as shown by negative cutaneous testings 1 month later. Our results show that A60 preparations satisfied the requirements of the European Pharmacopoeia Commission and met the WHO recommendations for new tuberculins. Handicaps of old tuberculin and PPD (heterogeneous mixtures titrated biologically and unstable in solution) can be overcome by A60 preparations (a single antigen spectrophoretically measurable and stable).
Topics: Animals; Antigens, Bacterial; Female; Hypersensitivity, Delayed; Injections, Subcutaneous; Mice; Skin Tests; Tuberculin; Tuberculosis
PubMed: 2733632
DOI: 10.1007/BF00203306 -
Frontiers in Immunology 2019Arthroplasty ranks among the greatest achievements of surgical medicine, with total hip replacement termed "the operation of the century." Despite its wide success,... (Review)
Review
Arthroplasty ranks among the greatest achievements of surgical medicine, with total hip replacement termed "the operation of the century." Despite its wide success, arthroplasty bears risks, such as local reactions to implant derived wear and corrosion products. Prevalence of allergies across Western society increases and along the number of reported hypersensitivity reactions to orthopedic implant materials. In this context the main focus is on delayed hypersensitivity (DTH). This mechanism is mainly attributed to T cells and an overreaction of the adaptive immune system. Arthroplasty implant materials are in direct contact with bone marrow (BM), which is discussed as a secondary lymphoid organ. However, the mechanisms of sensitization toward implant wear remain elusive. Nickel and cobalt ions can form haptens with native peptides to activate immune cell receptors and are therefore common T helper allergens in cutaneous DTH. The rising prevalence of metal-related allergy in the general population and evidence for the immune-modulating function of BM allow for the assumption hypersensitivity reactions could occur in peri-implant BM. There is evidence that pro-inflammatory factors released during DTH reactions enhance osteoclast activity and inhibit osteoblast function, an imbalance characteristic for osteolysis. Even though some mechanisms are understood, hypersensitivity has remained a diagnosis of exclusion. This review aims to summarize current views on the pathomechanism of DTH in arthroplasty with emphasis on BM and discusses recent advances and future directions for basic research and clinical diagnostics.
Topics: Animals; Arthroplasty; Bone Marrow; Humans; Hypersensitivity, Delayed; Metals; Prostheses and Implants
PubMed: 31620137
DOI: 10.3389/fimmu.2019.02232 -
Veterinary Immunology and... Nov 1982A technique to evaluate the cell mediated immune response in cats by the induction of delayed-type hypersensitivity to the strong contact sensitizer, 1-chloro, 2-4...
A technique to evaluate the cell mediated immune response in cats by the induction of delayed-type hypersensitivity to the strong contact sensitizer, 1-chloro, 2-4 dinitrobenzene is described. Following topical sensitization with this agent, challenge was done on the cats ear. Ear thickness measurements, the kinetics of the response and histopathologic examination of the tissue were used to assess this delayed-type hypersensitivity reaction. Based on the results it is shown that allergic contact dermatitis can be experimentally induced in the cat.
Topics: Animals; Cat Diseases; Cats; Dermatitis, Contact; Dinitrochlorobenzene; Ear; Female; Hypersensitivity, Delayed; Immunity, Cellular; Male; Nitrobenzenes; Skin
PubMed: 7179722
DOI: 10.1016/0165-2427(82)90041-1 -
Contact Dermatitis Jan 1996We report a case of delayed hypersensitivity to a low-molecular-weight heparin. The patient presented with eczema at the site of subcutaneous injections and allergy...
We report a case of delayed hypersensitivity to a low-molecular-weight heparin. The patient presented with eczema at the site of subcutaneous injections and allergy tests confirmed the clinical diagnosis. There were positive tests with 3 low-molecular-weight heparins and unfractionated subcutaneous calcium heparin but negative with intravenous sodium heparin. Although delayed hypersensitivity to low-molecular-weight heparins is rare, the possibility of cross-allergy to unfractionated heparin could be a therapeutic problem for some patients.
Topics: Eczema; Female; Heparin, Low-Molecular-Weight; Humans; Hypersensitivity, Delayed; Injections, Subcutaneous; Middle Aged; Patch Tests
PubMed: 8789222
DOI: 10.1111/j.1600-0536.1996.tb02108.x