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Journal of Dairy Science Sep 1971
Topics: Animals; Cattle; Cattle Diseases; Hypersensitivity, Delayed
PubMed: 5094707
DOI: No ID Found -
British Journal of Neurosurgery Jun 2024Modern neurosurgeons commonly rely on dural grafts to aid in obtaining watertight closures when the native dura itself cannot be approximated.
BACKGROUND
Modern neurosurgeons commonly rely on dural grafts to aid in obtaining watertight closures when the native dura itself cannot be approximated.
CASE PRESENTATION
We present a patient who developed a symptomatic, delayed hypersensitivity reaction to a cellulose-based synthetic dural graft, which resolved after reoperation and removal of the graft.
DISCUSSION
Dural grafts are a safe and common implant utilized in neurosurgery. Nevertheless, as with all implanted material, there is a chance for symptomatic immune reactions to occur.
CONCLUSION
This type of response is exceedingly uncommon, but recognition of this rare presentation may help other providers recognize it in the future.
Topics: Female; Humans; Middle Aged; Dura Mater; Hypersensitivity, Delayed; Neurosurgical Procedures; Postoperative Complications; Reoperation
PubMed: 34397313
DOI: 10.1080/02688697.2021.1967879 -
Clinical Allergy and Immunology 2000
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Annales de Dermatologie Et de... May 2012Heparin is widely used as an anticoagulant and is indicated in the prevention and treatment of thromboembolic disorders. Heparin-induced delayed-type hypersensitivity... (Review)
Review
Heparin is widely used as an anticoagulant and is indicated in the prevention and treatment of thromboembolic disorders. Heparin-induced delayed-type hypersensitivity presents as eczematous lesions, either at the injection site or generally, and affects 7.5% of patients on heparin. This poses diagnostic and therapeutic issues, since an alternative anticoagulant treatment is essential and the risk of cross-reactivity may be as high as 80%, depending on the type of heparin used. If delayed-type hypersensitivity is suspected, heparin-induced thrombocytopenia must first be ruled out, and heparin should be stopped. Fondaparinux is currently the first-line alternative, with a risk of cross-reactivity estimated at only 10%. The switch from a low-molecular-weight heparin (LMWH) to another LMWH is no longer recommended. The use of unfractionated heparin, danaparoid or hirudin may be warranted in the event of recurrence with fondaparinux, and an immuno-allergological work-up is needed to specify the exact profile of cross-allergies.
Topics: Anticoagulants; Decision Trees; Diagnosis, Differential; Heparin; Humans; Hypersensitivity, Delayed
PubMed: 22578340
DOI: 10.1016/j.annder.2012.01.017 -
British Medical Bulletin Jan 1967
Review
Topics: Hypersensitivity, Delayed; Macrophages
PubMed: 5342388
DOI: 10.1093/oxfordjournals.bmb.a070524 -
La Revue de Medecine Interne Nov 2017Allergy to beta-lactam antibiotics is a common condition and about 10% of patients report being allergic to penicillin. However, this diagnosis is largely overestimated.... (Review)
Review
Allergy to beta-lactam antibiotics is a common condition and about 10% of patients report being allergic to penicillin. However, this diagnosis is largely overestimated. Two types of allergy should be distinguished and include immediate hypersensitivity that can lead to anaphylactic shock and delayed hypersensitivity, ranging from the most common maculopapular exanthema to severe bullous toxidermia or life-threatening DRESS. Allergy challenge with oriented skin tests according to the clinical features, supplemented with oral challenge in the absence of contraindication, will confirm or invalidate the diagnosis of beta-lactam allergy and will help to identify if necessary safe alternatives to beta-lactams.
Topics: Anti-Bacterial Agents; Drug Hypersensitivity; Exanthema; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Skin Tests; beta-Lactams
PubMed: 28754229
DOI: 10.1016/j.revmed.2017.06.020 -
Contact Dermatitis Mar 2022
Topics: Adult; Anti-Ulcer Agents; Drug Eruptions; Humans; Hypersensitivity, Delayed; Male; Organometallic Compounds
PubMed: 34791673
DOI: 10.1111/cod.14009 -
Current Allergy and Asthma Reports Jan 2005Fluoroquinolone antibiotics cause immediate and delayed hypersensitivity reactions, and may also affect internal organs and circulating blood cells. The underlying... (Review)
Review
Fluoroquinolone antibiotics cause immediate and delayed hypersensitivity reactions, and may also affect internal organs and circulating blood cells. The underlying pathomechanisms are only partly understood. The extent of cross-reactivity among different quinolones depends on the type of clinical manifestation and its underlying mechanism. Despite recent advances, reliable diagnostic tests are still lacking. Recent studies have shown quinolone-specific IgE in vitro in more than 50% of patients with immediate-type reactions and a considerable cross-reactivity with related compounds. In maculopapular drug exanthems from ciprofloxacin, specific T-cell clones were identified, and cross-reactivity to related compounds was detected in approximately 50% of the clones. From re-exposure studies in patients with exanthems, cross-reactivity appears to be lower. Cellular tests such as lymphocyte transformation tests are currently not very useful. For prick and intradermal skin tests, widely divergent nonirritant test concentrations have been recommended. Desensitization may be possible in selected patients.
Topics: Adult; Aged; Aged, 80 and over; Desensitization, Immunologic; Drug Hypersensitivity; Female; Fluoroquinolones; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Immunity, Cellular; Incidence; Male; Middle Aged; Patch Tests; Prognosis; Risk Assessment; Sensitivity and Specificity
PubMed: 15659258
DOI: 10.1007/s11882-005-0049-1 -
Scientific Reports Sep 2017We demonstrate that conditioning of mammalian cells by electroporation with nanosecond pulsed electric field (nsPEF) facilitates their response to the next nsPEF...
We demonstrate that conditioning of mammalian cells by electroporation with nanosecond pulsed electric field (nsPEF) facilitates their response to the next nsPEF treatment. The experiments were designed to unambiguously separate the electroporation-induced sensitization and desensitization effects. Electroporation was achieved by bursts of 300-ns, 9 kV/cm pulses (50 Hz, n = 3-100) and quantified by propidium dye uptake within 11 min after the nsPEF exposure. We observed either sensitization to nsPEF or no change (when the conditioning was either too weak or too intense, or when the wait time after conditioning was too short). Within studied limits, conditioning never caused desensitization. With settings optimal for sensitization, the second nsPEF treatment became 2.5 times (25 °C) or even 6 times (37 °C) more effective than the same nsPEF treatment delivered without conditioning. The minimum wait time required for sensitization development was 30 s, with still longer delays increasing the effect. We show that the delayed hypersensitivity was not mediated by either cell swelling or oxidative effect of the conditioning treatment; biological mechanisms underlying the delayed electrosensitization remain to be elucidated. Optimizing nsPEF delivery protocols to induce sensitization can reduce the dose and adverse side effects of diverse medical treatments which require multiple pulse applications.
Topics: Cell Line, Tumor; Cell Membrane; Electroporation; Humans; Hypersensitivity, Delayed; Lipid Metabolism; Oxidation-Reduction; Temperature
PubMed: 28887559
DOI: 10.1038/s41598-017-10825-w -
Clinical and Experimental Allergy :... Sep 1998
Topics: Adult; Child; Drug Eruptions; Humans; Hypersensitivity, Delayed; Patch Tests; Penicillins; Radioallergosorbent Test; Skin Tests
PubMed: 9761027
DOI: No ID Found