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Military Medical Research Mar 2023
Topics: Humans; Tuberculin Test; Tuberculin; Hypersensitivity; Gene Expression; Hypersensitivity, Delayed
PubMed: 36922897
DOI: 10.1186/s40779-023-00450-2 -
Journal of Investigative Medicine High... 2022Many pediatric rheumatic diseases can be safely managed with biologic therapy. Severe allergic reactions to these medications are uncommon. We report the case of a...
Many pediatric rheumatic diseases can be safely managed with biologic therapy. Severe allergic reactions to these medications are uncommon. We report the case of a 2-year-old male with systemic-onset juvenile idiopathic arthritis and secondary macrophage activation syndrome (MAS), whose treatment was complicated by severe allergic reactions to biologics, including drug reaction with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity reaction (DIHR) likely due to anakinra, and anaphylactoid reaction to intravenous tocilizumab. These required transition to canakinumab, cyclosporine, and corticosteroids, with later development of interstitial lung disease and MAS flare needing transition from canakinumab to tofacitinib, which led to disease control. Whether lung disease is a manifestation of DRESS/DIHR to canakinumab remains unclear. High index of suspicion of hypersensitivity reactions for timely diagnosis and drug discontinuation is critical, especially in patients with active disease who might be at increased risk of these adverse events.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Biological Products; Child, Preschool; Humans; Hypersensitivity; Hypersensitivity, Delayed; Macrophage Activation Syndrome; Male
PubMed: 35225032
DOI: 10.1177/23247096221077836 -
Journal of Investigational Allergology... Jun 2023
Topics: Humans; Drug Hypersensitivity; Skin Tests; Alanine; Hypersensitivity, Delayed; Hypersensitivity, Immediate
PubMed: 35834314
DOI: 10.18176/jiaci.0844 -
Acta Dermatovenerologica Alpina,... Dec 2018Thiocolchicoside is a muscle relaxant, anti-inflammatory, and analgesic. Administered orally, intramuscularly, or topically, this drug is used in the symptomatic...
Thiocolchicoside is a muscle relaxant, anti-inflammatory, and analgesic. Administered orally, intramuscularly, or topically, this drug is used in the symptomatic treatment of muscular spasms and rheumatologic disorders. Despite its extensive use, thiocolchicoside is a very rare sensitizer. The case reported here is one of simultaneous contact urticaria and a delayed-type contact allergy to thiocolchicoside. The diagnosis was suggested by the patient's history and demonstrated by immediate and delayed positive skin test responses. The results of patch tests on intact skin (negative in immediate reading) and open tests (positive only on inflamed skin) may indicate that epicutaneously applied thiocolchicoside can induce an immediate reaction only when a damaged epidermal barrier is present. In contrast, skin integrity does not seem to prevent the appearance of a delayed-type reaction to this drug.
Topics: Adult; Colchicine; Dermatitis, Contact; Drug Hypersensitivity; Female; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate
PubMed: 30564833
DOI: No ID Found -
Orthopaedics & Traumatology, Surgery &... Sep 2015We report a case of allergic reaction after total cervical disc arthroplasty. A 52-year old woman was operated on for right C6 cervicobrachial neuralgia secondary to...
We report a case of allergic reaction after total cervical disc arthroplasty. A 52-year old woman was operated on for right C6 cervicobrachial neuralgia secondary to C5-C6 disc disease with foraminal stenosis. A cobalt-chromium-molybdenum total disc prosthesis had been implanted two years earlier. The patient was referred to our institution for recurrence of axial neck pain associated with abdominal patches of erythematous itching rash and swallowing disorder. Allergy tests confirmed type-4 allergic reaction to chromium. Symptoms decreased after removal of the prosthesis with secondary fusion. Delayed allergic reaction is uncommon in spine surgery, but should be considered in case of recurrence of initial symptomatology associated with non-spinal signs.
Topics: Cervical Vertebrae; Deglutition Disorders; Erythema; Female; Humans; Hypersensitivity, Delayed; Intervertebral Disc; Middle Aged; Neck Pain; Prostheses and Implants; Total Disc Replacement
PubMed: 26205565
DOI: 10.1016/j.otsr.2015.05.005 -
Allergy Proceedings : the Official... 1994Products containing natural rubber latex can cause both delayed and immediate hypersensitivity. Delayed reactions are induced by chemicals, primarily antidegradants and... (Review)
Review
Products containing natural rubber latex can cause both delayed and immediate hypersensitivity. Delayed reactions are induced by chemicals, primarily antidegradants and accelerators, integral to the manufacturing process. Immediate hypersensitivity is caused by protein antigen(s) that occur naturally in the latex. Different manufacturing stages can influence the concentration of these antigens, hence the allergenicity of the final product. The implications of manufacturing and regulatory issues for the diagnosis and treatment of natural rubber latex allergies are therefore discussed.
Topics: Cross Reactions; Humans; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Latex; Risk Factors; Skin Tests
PubMed: 8005451
DOI: 10.2500/108854194778816643 -
European Journal of Haematology Apr 2023Lenalidomide is considered a standard of care in multiple myeloma (MM) Some MM patients will develop delayed hypersensitivity to lenalidomide, which can lead to...
INTRODUCTION AND OBJECTIVES
Lenalidomide is considered a standard of care in multiple myeloma (MM) Some MM patients will develop delayed hypersensitivity to lenalidomide, which can lead to treatment discontinuation. Desensitization to lenalidomide can help these patients to complete treatment courses. Here, we aimed to review lenalidomide-treated MM patients who developed delayed hypersensitivity-induced rash and were treated with desensitization.
METHODS
A retrospective analysis of medical files of MM patients, who were desensitized to lenalidomide due to delayed hypersensitivity rash. Patients were treated between 2018 and 2022 at Hadassah Medical Center, Jerusalem, Israel.
RESULTS
Search of patients yielded 16 patients that underwent desensitization to lenalidomide within the study period. The desensitization protocol consisted of a slow, 3-week-long protocol with lenalidomide's target doses of 10, 15, and 25 mg/day. Of the 16 patients, 10 (62.5%) succeeded to complete the protocol and thus were able to complete lenalidomide treatment cycles. One patient with unsuccessful desensitization was subsequently treated with first-generation IMiD thalidomide, with no rash appearing. None of the patients that were treated with desensitization had severe immune-mediated or non-dermatological adverse reactions.
CONCLUSIONS
Desensitization to lenalidomide is safe and effective. Discontinuation of lenalidomide in MM patients with delayed hypersensitivity and no contraindication to desensitization should be discouraged. Collaboration between hematologists and allergists is needed.
Topics: Humans; Lenalidomide; Multiple Myeloma; Retrospective Studies; Exanthema; Hypersensitivity, Delayed
PubMed: 36565290
DOI: 10.1111/ejh.13918 -
Laboratory Investigation; a Journal of... Apr 1984
Review
Topics: Animals; Cell Division; Hypersensitivity, Delayed; Hypersensitivity, Immediate; Immunity, Cellular; Immunoglobulin E; Mast Cells; Mice; Mice, Mutant Strains; Passive Cutaneous Anaphylaxis; T-Lymphocytes
PubMed: 6368969
DOI: No ID Found -
European Journal of Dermatology : EJD Dec 2023
Topics: Animals; Humans; Insect Bites and Stings; Wasps; Hypersensitivity; Hypersensitivity, Delayed; Hypersensitivity, Immediate
PubMed: 38465560
DOI: 10.1684/ejd.2023.4630 -
British Medical Bulletin Jan 1967
Review
Topics: Antigen-Antibody Reactions; Hypersensitivity, Delayed; Immune Tolerance
PubMed: 5342374
DOI: 10.1093/oxfordjournals.bmb.a070510