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The Journal of Biological Chemistry Jul 1958
Topics: DNA; Escherichia coli
PubMed: 13563463
DOI: No ID Found -
Nature Jun 1962
Topics: DNA; Proteins; Ultraviolet Rays; Viola
PubMed: 13860354
DOI: 10.1038/194882a0 -
Proceedings of the National Academy of... Mar 1962
Topics: Biochemical Phenomena; Bromouracil; DNA; DNA Replication; Uracil
PubMed: 13922323
DOI: 10.1073/pnas.48.3.449 -
Journal of Virology Nov 1971Intermediates in the synthesis of adenovirus type 2 deoxyribonucleic acid (DNA) were studied in HeLa cells. Pieces of DNA smaller than the viral genome were demonstrated...
Intermediates in the synthesis of adenovirus type 2 deoxyribonucleic acid (DNA) were studied in HeLa cells. Pieces of DNA smaller than the viral genome were demonstrated after labeling with (3)H-thymidine for 10 to 240 sec. Intermediates as small as the Okazaki fragments (8 to 10S) do not predominate at any of the above times. No detectable addition of nucleotides to parental genome could be shown, nor was there any breakdown of recently synthesized viral DNA. The DNA intermediates were of viral origin for they hybridized to viral DNA and were made at a stage of the cell cycle (G(2)) when host DNA is not synthesized.
Topics: Adenoviridae; Carbon Isotopes; Centrifugation, Density Gradient; Cesium; Chlorides; DNA; DNA Replication; DNA, Viral; HeLa Cells; Humans; Nucleic Acid Hybridization; Nucleotides; Peptide Chain Elongation, Translational; Serotyping; Sucrose; Thymidine; Time Factors; Tritium
PubMed: 5132696
DOI: 10.1128/JVI.8.5.675-683.1971 -
Archives of Biochemistry and Biophysics Mar 1959
Topics: Berberine; Biological Products; DNA; Hydrastis; Light
PubMed: 13637970
DOI: 10.1016/0003-9861(59)90179-1 -
The Journal of Biological Chemistry Jun 1962
Topics: Bacteriophages; DNA; Escherichia coli; Transferases
PubMed: 14452558
DOI: No ID Found -
Proceedings of the National Academy of... Jun 1961
Topics: DNA
PubMed: 13712607
DOI: 10.1073/pnas.47.6.825 -
Nature Sep 1960
Topics: DNA; Dactinomycin
PubMed: 13751973
DOI: 10.1038/1871112a0 -
Proceedings of the National Academy of... Jul 1962
The role of deoxyribonucleic acid in ribonucleic acid synthesis. III. The inhibition of the enzymatic synthesis of ribonucleic acid and deoxyribonucleic acid by actinomycin D and proflavin.
Topics: Biochemical Phenomena; DNA; Dactinomycin; Flavins; Proflavine; RNA
PubMed: 14450185
DOI: 10.1073/pnas.48.7.1222 -
Molecular and Cellular Biology Aug 1981The genome of Abelson murine leukemia virus (A-MuLV) consists of sequences derived from both BALB/c mouse deoxyribonucleic acid and the genome of Moloney murine leukemia...
The genome of Abelson murine leukemia virus (A-MuLV) consists of sequences derived from both BALB/c mouse deoxyribonucleic acid and the genome of Moloney murine leukemia virus. Using deoxyribonucleic acid linear intermediates as a source of retroviral deoxyribonucleic acid, we isolated a recombinant plasmid which contained 1.9 kilobases of the 3.5-kilobase mouse-derived sequences found in A-MuLV (A-MuLV-specific sequences). We used this clone, designated pSA-17, as a probe restriction enzyme and Southern blot analyses to examine the arrangement of homologous sequences in BALB/c deoxyribonucleic acid (endogenous Abelson sequences). The endogenous Abelson sequences within the mouse genome were interrupted by noncoding regions, suggesting that a rearrangement of the cell sequences was required to produce the sequence found in the virus. Endogenous Abelson sequences were arranged similarly in mice that were susceptible to A-MuLV tumors and in mice that were resistant to A-MuLV tumors. An examination of three BALB/c plasmacytomas and a BALB/c early B-cell tumor likewise revealed no alteration in the arrangement of the endogenous Abelson sequences. Homology to pSA-17 was also observed in deoxyribonucleic acids prepared from rat, hamster, chicken, and human cells. An isolate of A-MuLV which encoded a 160,000-dalton transforming protein (P160) contained 700 more base pairs of mouse sequences than the standard A-MuLV isolate, which encoded a 120,000-dalton transforming protein (P120).
Topics: 3T3 Cells; Abelson murine leukemia virus; Animals; Chromosome Mapping; Cloning, Molecular; Cricetinae; DNA; DNA, Viral; Humans; Mice; Mice, Inbred Strains; Nucleic Acid Hybridization; Rats; Restriction Mapping; Sequence Homology, Nucleic Acid
PubMed: 9279386
DOI: 10.1128/mcb.1.8.731-742.1981