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Skin Pharmacology and Physiology 2008We report on a double-blind, vehicle-controlled, single-center confirmatory study with random assignment. The purpose of the study was to investigate the topical... (Comparative Study)
Comparative Study Randomized Controlled Trial
INTRODUCTION
We report on a double-blind, vehicle-controlled, single-center confirmatory study with random assignment. The purpose of the study was to investigate the topical bioavailability of different topical corticosteroid formulations in healthy human beings focussing on desoximetasone (DM).
MATERIALS AND METHODS
Two DM 0.25% formulations [ointment (DM-o) and fatty ointment (DM-fo, water-free); class III corticosteroids], the corresponding active ingredient-free vehicles and three comparators of different strength [clobetasol propionate 0.05% (CP 0.05%), fatty ointment, class IV; hydrocortisone (HC) 1%, fatty ointment, class I, and betamethasone (BM) 0.05%, fatty ointment, class III] were tested using the vasoconstriction assay. The degree of vasoconstriction (blanching) in the treatment field was compared to the one found in untreated control fields using chromametric measurements and clinical assessment.
RESULTS/CONCLUSION
DM-o 0.25%, DM-fo 0.25% and BM 0.05% showed similar vasoconstrictive potential, i.e., clear blanching. In fact, both DM preparations were proven to be noninferior to BM 0.05%, while CP 0.05% was found a little less active. HC 1.0% and the DM vehicles showed no clear-cut vasoconstrictive effect. No adverse events related to the study medications were observed. Good topical bioavailability of both DM formulations was detected by chromametric measurement and clinical assessment.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Betamethasone; Biological Availability; Clobetasol; Desoximetasone; Double-Blind Method; Female; Humans; Hydrocortisone; Male; Middle Aged; Pharmaceutical Vehicles; Skin; Skin Absorption; Vasoconstriction; Vasoconstrictor Agents
PubMed: 18523415
DOI: 10.1159/000131082 -
The Medical Letter on Drugs and... Oct 1977
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Dexamethasone; Glucocorticoids; Humans; Infant
PubMed: 909507
DOI: No ID Found -
The British Journal of Dermatology Jul 1981Twenty-two patients were treated with desoximetasone emollient cream 0.25% twice daily without occlusion for 6 months. Patients applied the medication to approximately... (Clinical Trial)
Clinical Trial
Twenty-two patients were treated with desoximetasone emollient cream 0.25% twice daily without occlusion for 6 months. Patients applied the medication to approximately one-third of their body over psoriatic lesions. Corticosteroid plasma cortisol values decreased to below normal limits in nine patients before the 6-month study was terminated. In four of these the plasma cortisol spontaneously returned to normal despite therapy; in four other patients, however, the plasma cortisol was still suppressed at the end of 5 months of continual therapy but returned to normal within 7 days of discontinuation of the medication. In one patient, lost to further follow-up at 5 1/2 months of therapy, the trend at the fourth month was an increase in plasma cortisol to within one unit of normal range. Betamethasone 17-valerate 0.1% cream applied twice daily did not suppress plasma cortisol in twenty-three patients similarly tested. The clinical response to desoximetasone emollient cream was significantly better than to betamethasone valerate cream. This study closely approximates the way in which many patients with steroid-responsive dermatoses use potent topical steroids, namely over a long time period and without occlusion.
Topics: Adolescent; Adult; Aged; Betamethasone; Betamethasone Valerate; Desoximetasone; Dexamethasone; Female; Humans; Hydrocortisone; Male; Middle Aged; Pituitary-Adrenal System; Psoriasis
PubMed: 7259982
DOI: 10.1111/j.1365-2133.1981.tb00888.x -
International Journal of Dermatology May 1975A comparative clinical evaluation of desoximetasone, a corticosterone derivative by a double blind study showed that desoximetasone has potent topical activity as... (Clinical Trial)
Clinical Trial Comparative Study Randomized Controlled Trial
A comparative clinical evaluation of desoximetasone, a corticosterone derivative by a double blind study showed that desoximetasone has potent topical activity as effective as betamethasone valerate and probably more effective than triamcinolone acetonide.
Topics: Adolescent; Adult; Aged; Betamethasone; Child; Clinical Trials as Topic; Corticosterone; Dexamethasone; Drug Evaluation; Female; Humans; Male; Middle Aged; Psoriasis; Skin Diseases; Triamcinolone Acetonide; Valerates
PubMed: 1093984
DOI: 10.1111/j.1365-4362.1975.tb00111.x -
Dermatitis : Contact, Atopic,... Sep 2006A 60-year-old man developed a bullous contact dermatitis after topical corticosteroid treatment of dermatitis on his lower leg. Subsequent patch testing showed...
A 60-year-old man developed a bullous contact dermatitis after topical corticosteroid treatment of dermatitis on his lower leg. Subsequent patch testing showed cross-reactions to numerous group B and group D corticosteroids as well as cross-reactions to group C desoximetasone and group D1 mometasone furoate. His patch-test result was negative for the group A corticosteroids hydrocortisone and tixocortol pivalate. We discuss the uncommon finding of cross-reactions to desoximetasone and mometasone furoate.
Topics: Administration, Cutaneous; Anti-Inflammatory Agents; Asthma; Cross Reactions; Dermatitis, Allergic Contact; Desoximetasone; Diagnosis, Differential; Humans; Leg; Male; Middle Aged; Mometasone Furoate; Patch Tests; Pregnadienediols; Rhinitis, Allergic, Seasonal
PubMed: 16956468
DOI: 10.2310/6620.2006.05053 -
South African Medical Journal =... Aug 1978Desoximetasone (Topisolon; Hoechst), a new topical steroid, and betamethasone 17-valerate were compared with respect to their effects on hypothalamic-pituitary-adrenal... (Clinical Trial)
Clinical Trial Comparative Study Randomized Controlled Trial
Desoximetasone (Topisolon; Hoechst), a new topical steroid, and betamethasone 17-valerate were compared with respect to their effects on hypothalamic-pituitary-adrenal function as evidenced by plasma cortisol concentrations. Three grams of each test preparation were applied daily for 21 days to intact skin of the ventral aspects of alternate forearms of 15 normal volunteers. Five received betamethasone 17-valerate 0.1%, 5 desoximetasone 0.05%, and 5 desoximetasone 0.25%. Plasma cortisol levels were determined before and after the initial applications on days 1, 3, 10, 17, 22, 24 and 28. These values were compared with the mean control values by analysis of covariance. There was no significant difference in plasma cortisol levels. The value of performing similar studies on larger skin areas and with larger doses is discussed.
Topics: Administration, Topical; Adult; Betamethasone; Betamethasone Valerate; Clinical Trials as Topic; Depression, Chemical; Desoximetasone; Dexamethasone; Female; Humans; Hydrocortisone; Male; Skin
PubMed: 362568
DOI: No ID Found -
Archives of Dermatology Oct 2000
Clinical Trial Randomized Controlled Trial
Topics: Adolescent; Adult; Alopecia; Desoximetasone; Double-Blind Method; Humans; Middle Aged; Ointments; Placebos
PubMed: 11030789
DOI: 10.1001/archderm.136.10.1276 -
Journal of Pharmaceutical and... Jun 1996The proposed method is based on coloured hydrazone formation with 1,4-dihydrazinophthalazine as a reagent. Heating at 85 degrees C for 2 h was found necessary to ensure...
The proposed method is based on coloured hydrazone formation with 1,4-dihydrazinophthalazine as a reagent. Heating at 85 degrees C for 2 h was found necessary to ensure optimal hydrazone formation in the presence of hydrochloric acid. The yellow hydrazone product has an absorption maximum at 380 nm. A linear relationship between absorbance and concentration was established in the concentration range 3.19 x 10(-6) -3.19 x 10(-5) mol l-1 (the regression equation was y = 0.013 167 3 + 0.019 025 9x; correlation coefficient r = 0.9991; n = 6). The detection limit was 1.2 micrograms ml-1 (molar absorptivity found was 1.97 x 10(4) l mol-1 cm-1). The reliability of the proposed method was checked at three different concentrations; the relative standard deviation (RSD) varied from 1.03 to 2.01%. The described method applied to the determination of desoximetasone in ointment gave precise and reproducible results; the recovery was 98.55% with RSD = 2.40% (n = 10).
Topics: Desoximetasone; Dihydralazine; Ointments; Spectrophotometry, Ultraviolet
PubMed: 8817999
DOI: 10.1016/0731-7085(95)01681-3 -
European Journal of Clinical... May 1980The effect of topical use of desoximetasone (Topisolon ointment) and triamcinolone acetonide (Volon A cream) for 3 to 4 days on circadian plasma cortisol levels was... (Comparative Study)
Comparative Study
The effect of topical use of desoximetasone (Topisolon ointment) and triamcinolone acetonide (Volon A cream) for 3 to 4 days on circadian plasma cortisol levels was studied in 22 hospitalized patients (mean age 61 years) for Topisolon, and in ten patients (mean age 59 years) for Volon A. The differences in cortisol levels (RIA) were examined by the frequency distribution analysis of Daeves and Beckel (1958). The need to analyze the features of the distribution curves was clearly demonstrated in preference to simple averaging statistics which rely upon the arithmetic mean as the main parameter. The results suggest two distinct groups of morning plasma cortisol levels - one at a low level of 5.6 X 1.85 +/- 1 and one at a high level of 15.4 X 1.56 +/- 1 microgram/100 ml. The evening level was uniform 6.5 X 2.13 +/- 1 microgram/100 ml. Topisolon depressed the plasma cortisol levels in all groups. Volon A seemed to reduce only the morning high level group to lower values. In addition, Topisolon altered the proportions of patients with high and low plasma cortisol levels, while Volon A had little effect. The different responses of the plasma cortisol levels may imply different kinetics of cutaneous penetration and cutaneous metabolism of the two synthetic corticosteroids.
Topics: Administration, Topical; Adult; Circadian Rhythm; Desoximetasone; Dexamethasone; Female; Humans; Hydrocortisone; Male; Middle Aged; Skin; Triamcinolone; Triamcinolone Acetonide
PubMed: 6893435
DOI: 10.1007/BF00558449 -
Indian Journal of Dermatology Oct 1974
Clinical Trial Comparative Study
Topics: Adolescent; Adult; Aged; Betamethasone; Clinical Trials as Topic; Dexamethasone; Female; Humans; Male; Middle Aged; Skin Diseases; Triamcinolone Acetonide
PubMed: 4615062
DOI: No ID Found