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Anaerobe Feb 2018Desulfovibrio spp. are sulfate-reducing, anaerobic bacteria that are ubiquitously found in the environment. These organisms infrequently cause human infections, and the... (Review)
Review
Desulfovibrio spp. are sulfate-reducing, anaerobic bacteria that are ubiquitously found in the environment. These organisms infrequently cause human infections, and the clinical characteristics of infection with Desulfovibrio spp. remain unclear. Here, we describe a case of Desulfovibrio desulfuricans bacteremia in an 88-year-old Japanese man with a past medical history of thoracic endovascular aortic repair (TEVAR). His chief complaint was hemoptysis for 2 weeks. A chest contrast-enhanced computed tomography demonstrated an enlarged thoracic aortic aneurysm surrounded by a ring-enhanced lesion, recognized as mediastinal abscess. Gram-negative spiral bacilli were detected in anaerobic blood culture. These bacteria could not be identified using conventional methods, but by analyzing a full base sequence of 16S rDNA, they were identified as D. desulfuricans subsp. desulfuricans. The patient underwent an emergent re-TEVAR, and the infection subsided after being treated with tazobactam/piperacillin and clindamycin, followed by metronidazole. A literature review of previous cases of D. desulfuricans bacteremia suggested that the pathogen was derived from bacterial translocation from the intestine in most cases. Desulfovibrio infection is presumably underestimated due to its infrequency, indolent growth, and difficulty in identification. Desulfovibrio spp. should be suspected when spiral rods are observed in anaerobic culture, and molecular analysis is required for accurate species-level differentiation of the pathogens. To better understand the pathogenicity of these fastidious organisms, further cases based on the exact bacterial identification should be investigated.
Topics: Aged; Aged, 80 and over; Bacteremia; Desulfovibrio desulfuricans; Desulfovibrionaceae Infections; Female; Humans; Male; Middle Aged
PubMed: 29305996
DOI: 10.1016/j.anaerobe.2017.12.013 -
EBioMedicine Apr 2024Chemoresistance is a critical factor contributing to poor prognosis in clinical patients with cancer undergoing postoperative adjuvant chemotherapy. The role of gut...
BACKGROUND
Chemoresistance is a critical factor contributing to poor prognosis in clinical patients with cancer undergoing postoperative adjuvant chemotherapy. The role of gut microbiota in mediating resistance to tumour chemotherapy remains to be investigated.
METHODS
Patients with CRC were categorised into clinical benefit responders (CBR) and no clinical benefit responders (NCB) based on chemotherapy efficacy. Differential bacterial analysis using 16S rRNA sequencing revealed Desulfovibrio as a distinct microbe between the two groups. Employing a syngeneic transplantation model, we assessed the effect of Desulfovibrio on chemotherapy by measuring tumour burden, weight, and Ki-67 expression. We further explored the mechanisms underlying the compromised chemotherapeutic efficacy of Desulfovibrio using metabolomics, western blotting, colony formation, and cell apoptosis assays.
FINDINGS
In comparison, Desulfovibrio was more abundant in the NCB group. In vivo experiments revealed that Desulfovibrio colonisation in the gut weakened the efficacy of FOLFOX. Treatment with Desulfovibrio desulfuricans elevates serum S-adenosylmethionine (SAM) levels. Interestingly, SAM reduced the sensitivity of CRC cells to FOLFOX, thereby promoting the growth of CRC tumours. These experiments suggest that SAM promotes the growth and metastasis of CRC by driving the expression of methyltransferase-like 3 (METTL3).
INTERPRETATION
A high abundance of Desulfovibrio in the intestines indicates poor therapeutic outcomes for postoperative neoadjuvant FOLFOX chemotherapy in CRC. Desulfovibrio drives the manifestation of METTL3 in CRC, promoting resistance to FOLFOX chemotherapy by increasing the concentration of SAM.
FUNDING
This study is supported by Wuxi City Social Development Science and Technology Demonstration Project (N20201005).
Topics: Humans; Apoptosis; Colorectal Neoplasms; Desulfovibrio desulfuricans; Fluorouracil; Methyltransferases; RNA, Ribosomal, 16S; Leucovorin; Organoplatinum Compounds; Antineoplastic Combined Chemotherapy Protocols
PubMed: 38484555
DOI: 10.1016/j.ebiom.2024.105041 -
Genes & Diseases Jan 2023It is increasingly aware that gut microbiota is closely associated with atherosclerosis. However, which and how specific gut bacteria regulate the progression of...
It is increasingly aware that gut microbiota is closely associated with atherosclerosis. However, which and how specific gut bacteria regulate the progression of atherosclerosis is still poorly understood. In this study, modified linear discriminant analysis was performed in comparing the gut microbiota structures of atherosclerotic and non-atherosclerotic mice, and () was found to be associated with atherosclerosis. treated mice showed significantly aggravated atherosclerosis. The proatherogenic effect of was attributed to its ability to increase intestinal permeability and subsequent raise in the transit of lipopolysaccharide (LPS) from the intestine to the bloodstream. Excessive LPS in the blood can elicit local and systemic inflammation and activate Toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) signaling of endothelial cells. TAK-242, a specific inhibitor of TLR4, can ameliorate the development of -induced atherosclerosis by blocking the LPS-induced activation of TLR4/NF-κB signaling.
PubMed: 37013030
DOI: 10.1016/j.gendis.2021.09.007 -
Medecine Et Maladies Infectieuses May 2014
Topics: Adenocarcinoma; Aged; Anaerobiosis; Anti-Bacterial Agents; Bacteremia; Bacteriological Techniques; Bacteroides Infections; Campylobacter Infections; Coinfection; Colonic Neoplasms; Desulfovibrio desulfuricans; Desulfovibrionaceae Infections; Drug Therapy, Combination; Humans; Intestinal Perforation; Intestine, Small; Male; Neoplasm Recurrence, Local; Peritonitis; Postoperative Complications; Systemic Inflammatory Response Syndrome
PubMed: 24768196
DOI: 10.1016/j.medmal.2014.03.002 -
Emerging Infectious Diseases Aug 2023An 84-year-old man in Japan who had undergone endovascular aortic repair 9 years earlier had an infected aneurysm develop. We detected Desulfovibrio desulfuricans MB at...
An 84-year-old man in Japan who had undergone endovascular aortic repair 9 years earlier had an infected aneurysm develop. We detected Desulfovibrio desulfuricans MB at the site. The patient recovered after surgical debridement, artificial vessel replacement, and appropriate antimicrobial therapy. Clinicians should suspect Desulfovibrio spp. infection in similar cases.
Topics: Male; Humans; Aged, 80 and over; Desulfovibrio desulfuricans; Aneurysm; Japan
PubMed: 37486321
DOI: 10.3201/eid2908.230403 -
Anaerobe Aug 2021Septic arthritis can occur by hematogenous seeding, direct joint inoculation, or extension of a bone infection into the joint. We report a case of septic arthritis of... (Review)
Review
Septic arthritis can occur by hematogenous seeding, direct joint inoculation, or extension of a bone infection into the joint. We report a case of septic arthritis of the hip caused by Desulfovibrio desulfuricans, an anaerobic sulfur-reducing bacteria. The patient underwent debridement followed by targeted antibiotic therapy with infection resolution.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Arthritis, Infectious; Desulfovibrio desulfuricans; Female; Humans; Male; Middle Aged
PubMed: 34153468
DOI: 10.1016/j.anaerobe.2021.102407 -
Microorganisms Dec 2021The sulphate-reducing bacteria (SRB) of genus are a group of prokaryotes associated with autism spectrum disorders (ASD). The connection between the elevated numbers of...
The sulphate-reducing bacteria (SRB) of genus are a group of prokaryotes associated with autism spectrum disorders (ASD). The connection between the elevated numbers of in the gut of children with ASD compared with healthy children remains unresolved. A conceivable consequence of SRB overgrowth in the gut is the conversion of bioavailable iron into low-soluble crystalline iron sulphides, causing iron deficiency in the organism. In this study, we report the draft genome sequence and physiological features of the first cultivable isolate from a patient with ASD, strain AY5.The capability of the strain to produce crystalline iron sulphides was studied under different pH conditions. The most notable greigite(FeS) and pyrite (FeS) formation was revealed at pH 6.0, which suggests that the iron loss due to insoluble sulphide formation may occur in the proximal part of the gastrointestinal tract. Strain AY5 was adapted to grow under nitrogen-limiting conditions by N fixation. The urease found in the strain's genome may play a role in resistance to acidic pH.
PubMed: 34946159
DOI: 10.3390/microorganisms9122558 -
Journal of Clinical Microbiology Jun 2003One case of primary Desulfovibrio desulfuricans bacteremia in an immunocompetent man is presented, and 15 other reported cases are reviewed. While most isolates have not... (Review)
Review
One case of primary Desulfovibrio desulfuricans bacteremia in an immunocompetent man is presented, and 15 other reported cases are reviewed. While most isolates have not been identified to the species level, Desulfovibrio fairfieldensis and D. desulfuricans have been associated with incidents of bacteremia and D. vulgaris has been associated with intra-abdominal infections. In vitro studies suggest that empirical therapy with either imipenem or metronidazole should be considered.
Topics: Bacteremia; Desulfovibrio; Gram-Negative Bacterial Infections; Humans; Immunocompetence; Male; Middle Aged
PubMed: 12791922
DOI: 10.1128/JCM.41.6.2752-2754.2003 -
Journal of Infection and Chemotherapy :... May 2018A 73-year-old woman was admitted with consciousness disturbance following a fever. Abdominal computed tomography revealed a large liver abscess with which the presence... (Review)
Review
A 73-year-old woman was admitted with consciousness disturbance following a fever. Abdominal computed tomography revealed a large liver abscess with which the presence of Desulfovibrio desulfuricans and Escherichia coli was confirmed by thorough blood and abscess content culture. Empiric meropenem treatment was switched to cefoperazone/sulbactam, followed by ampicillin/sulbactam based on susceptibility testing. Desulfovibrio desulfuricans is a common bacterium that rarely causes liver abscess and may be overlooked during co-infection due to overgrowth of the accompanying bacteria. Clinicians should bear Desulfovibrio desulfuricans in mind and select the appropriate antibiotics according to susceptibility testing when anaerobic bacteria are detected in a liver abscess.
Topics: Aged; Ampicillin; Cefoperazone; Coinfection; Desulfovibrio desulfuricans; Desulfovibrionaceae Infections; Drug Therapy, Combination; Escherichia coli; Escherichia coli Infections; Female; Humans; Liver Abscess; Meropenem; Thienamycins
PubMed: 29249641
DOI: 10.1016/j.jiac.2017.11.006 -
Environmental Research Nov 2023Uranium pollution in groundwater environment has become an important issue of global concern. In this study, a strain of Desulfovibrio desulfuricans was isolated from...
Uranium pollution in groundwater environment has become an important issue of global concern. In this study, a strain of Desulfovibrio desulfuricans was isolated from the tailings of acid heap leaching, and was shown to be able to remove uranium from water via biosorption, bio-reduction, passive biomineralization under uranium stress, and active metabolically dependent bioaccumulation. This research explored the effects of nutrients, pH, initial uranium and sulfate concentration on the functional groups, uranium valence, and crystal size and morphology of uranium immobilization products. Results showed that tetravalent and hexavalent phosphorus-containing uranium minerals was both formed. In sulfate-containing water where Desulfovibrio desulfuricans A3-21ZLL can grow, the sequestration of uranium by bio-reduction was significantly enhanced compared to that with no sulfate loading or no growth. Ungrown Desulfovibrio desulfuricans A3-21ZLL or dead ones released inorganic phosphate group in response to the stress of uranium, which associated with soluble uranyl ion to form insoluble uranium-containing precipitates. This study revealed the influence of hydrochemical conditions on the mineralogy characteristics and spatial distribution of microbial uranium immobilization products. This study is conducive to the long-term and stable bioremediation of groundwater in decommissioned uranium mining area.
PubMed: 37660876
DOI: 10.1016/j.envres.2023.116950