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Nigerian Journal of Medicine : Journal... 2007To investigate the in-vivo effects of intravenous administration of sodium meglumine diatrizoate on some haematological parameters in a Nigerian population. (Comparative Study)
Comparative Study
BACKGROUND
To investigate the in-vivo effects of intravenous administration of sodium meglumine diatrizoate on some haematological parameters in a Nigerian population.
METHODS
Blood samples were collected before and one hour after intravenous injection of sodium-meglumine diatrizoate from 50 subjects undergoing intravenous urography examinations who had no history of and laboratory confirmed diseases that may affect haematological parameters. Standard laboratory methods were used to assay the haemoglobin concentration (Hb), packed cell volume (PCV), total white blood cell (WBC) count and differentials and blood film for any morphological changes in the red blood cells (RBC). Comparisons were made between the mean values of these haematological parameters before and one hour post injection using paired t-test for any statistically significant differences.
RESULTS
There were statistically significant reductions in the mean values of Hb concentration and the neutrophil count one hour post injection compared with their pretest values (p < 0.05). The lymphocytes were also significantly increased post injection compared to the pretest values whereas 70% of the erythrocytes were morphologically altered from their approximately 100% normocytic shape at pre-test.
CONCLUSION
Intravenous administration of sodium-meglumine diatrizoate causes in-vivo reduction in Hb concentration and neutrophil count in humans as well as poikilocytosis of the erythrocytes. Some of these effects have the potential of triggering or exacerbating crisis in a sickle cell anaemia subject which is endemic in our locality. Caution should therefore be exercised in the choice and administration of radiological contrast agents to sickle cell subjects. Preparations that are iso-osmolar with plasma and have less probability in precipitating crises should be preferred instead.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Contrast Media; Diatrizoate Meglumine; Erythrocytes; Female; Hemoglobins; Humans; Lymphocytes; Male; Middle Aged; Neutrophils; Pilot Projects
PubMed: 18080596
DOI: 10.4314/njm.v16i4.37338 -
Radiology Apr 1990The pressures generated by a barium suspension and various solutions of meglumine sodium diatrizoate in water were measured with a manometer. A pressure of 120 mm Hg was... (Comparative Study)
Comparative Study
The pressures generated by a barium suspension and various solutions of meglumine sodium diatrizoate in water were measured with a manometer. A pressure of 120 mm Hg was produced by a 3.5-foot (105-cm) column of 60% wt/vol barium and a 5-foot (150-cm) column of either a 1:3 or 1:4 solution of meglumine sodium diatrizoate and water. This is the pressure used to reduce an intussusception with air.
Topics: Barium; Child; Diatrizoate Meglumine; Humans; Hydrostatic Pressure; Intussusception; Pediatrics; Solutions; Suspensions; Water
PubMed: 2315470
DOI: 10.1148/radiology.175.1.2315470 -
Investigative Radiology 1978Selective renal angiography causes a biphasic change in renal blood flow and vascular resistance. In this study, 5 ml of meglumine/sodium diatrizoate (288 mg I/ml, 1455... (Comparative Study)
Comparative Study
Selective renal angiography causes a biphasic change in renal blood flow and vascular resistance. In this study, 5 ml of meglumine/sodium diatrizoate (288 mg I/ml, 1455 mosm/kg), metrizamide (290 mg I/ml, 593 mosm/kg), isontonic saline (287 mosm/kg) and hypertonic saline (1500 mosm/kg) were injected into the renal arteries of seven adult mongrel dogs to determine whether the minimum flow (or maximum resistance) was related to the osmolality of the injected agent. The maximum resistance response was significantly smaller for metrizamide (20 +/- 4%) and isotonic saline (19 +/- 2%) than for diatrizoate (36 +/- 6%) or hypertonic saline (50 +/- 7%). Hypertonic saline produced two distinct types of responses: the typical biphasic response or a severe immediate drop in flow. Thus the maximum resistance response was related to agent osmolality. The "injection artifact," or flow changes occurring during the injection, were different for the four agents, and these differences appeared correlated to agent viscosity. Although both contrast media caused relatively small changes in renal hemodynamics, metrizamide caused significantly smaller changes than meglumine/sodium diatrizoate.
Topics: Animals; Blood Circulation; Diatrizoate; Diatrizoate Meglumine; Dogs; Female; Injections, Intra-Arterial; Kidney; Male; Metrizamide; Osmolar Concentration; Radiography; Renal Artery; Vascular Resistance
PubMed: 632051
DOI: 10.1097/00004424-197801000-00015 -
Neurology Sep 1985The neurotoxic effects in cerebral angiography of three iodinated ionic contrast media, nonionic iopamidol, 25% mannitol, and saline controls were compared in 25...
The neurotoxic effects in cerebral angiography of three iodinated ionic contrast media, nonionic iopamidol, 25% mannitol, and saline controls were compared in 25 rabbits. Diatrizoate sodium meglumine was the most toxic agent, followed by diatrizoate and meglumine, iothalamate meglumine, and mannitol in terms of blood-brain barrier (BBB) disruption and coupled perfusion decline. HIPDm distribution was more sensitive than trypan blue extravasation for monitoring brain dysfunction. Iopamidol and saline controls exhibited no visual BBB breakdown or alteration in regional uptake of I-125 HIPDm, confirming the safety of nonionic iopamidol as compared with presently used ionic contrast media.
Topics: Animals; Blood-Brain Barrier; Brain; Cerebral Angiography; Contrast Media; Diatrizoate Meglumine; Iopamidol; Iothalamate Meglumine; Iothalamic Acid; Mannitol; Neurotoxins; Rabbits; Respiratory System
PubMed: 3927186
DOI: 10.1212/wnl.35.9.1290 -
Israel Journal of Medical Sciences Mar 1980The effects of direct intracoronary injection of meglumine diatrizoate (RENOGRAFIN) on regional myocardial contractility were studied in 11 open-chested dogs. The left...
The effects of direct intracoronary injection of meglumine diatrizoate (RENOGRAFIN) on regional myocardial contractility were studied in 11 open-chested dogs. The left anterior descending or circumflex artery was cannulated selectively from the ascending aorta and the changes in myocardial contractile force and its first derivative were measured by an epicardial strain gauge sutured to the myocardium supplied by the cannulated artery. The myocardium perfused by the non-cannulated artery served as the control area. Direct intracoronary injection of meglumine diatrizoate, 1 ml, caused regional depression of myocardial function, with a significant decrease in contractile force and its first derivative in the study area; there was no change in the control area, nor were there changes in the first derivative of left ventricular pressure, heart rate or systemic blood pressure. There was no additive depressant effect after multiple injections. Local pretreatment with hydrocortisone (4 mg/kg, by slow intracoronary infusion) ameliorated the myocardial depressant effect of meglumine diatrizoate so that there was a smaller decrease in contractile force and its first derivative. The results may have clinical significance in patients undergoing coronary arteriography.
Topics: Animals; Blood Pressure; Diatrizoate; Diatrizoate Meglumine; Dogs; Electrocardiography; Hydrocortisone; Myocardial Contraction; Time Factors
PubMed: 7390758
DOI: No ID Found -
AJR. American Journal of Roentgenology Nov 1998
Topics: Administration, Oral; Adult; Contrast Media; Diatrizoate; Diatrizoate Meglumine; Humans; Male; Stevens-Johnson Syndrome
PubMed: 9798850
DOI: 10.2214/ajr.171.5.9798850 -
AJNR. American Journal of Neuroradiology 1984The effect of an intravenous bolus of 4.3 ml/kg of 60% meglumine diatrizoate on the blood-brain barrier (BBB) was studied in five adult unanesthetized dogs. Intravenous...
The effect of an intravenous bolus of 4.3 ml/kg of 60% meglumine diatrizoate on the blood-brain barrier (BBB) was studied in five adult unanesthetized dogs. Intravenous 3% Evans blue dye (4 ml/kg) was used as an indicator of BBB disruption. The animals were observed for signs of neurotoxicity for 1 hr after contrast-medium injection and then sacrificed. Their brains were removed and sectioned. None of the dogs displayed clinical evidence of neurotoxicity, and none of the brain specimens showed evidence of BBB disruption. The authors concluded that there is a statistically significant lack of correlation between the intravenous administration of 4.3 ml/kg of 60% meglumine diatrizoate and BBB disruption (p less than 0.05 with a probability of 90%). A previous publication reported focal BBB disruption in anesthetized dogs with dosages of 4 ml/kg and 6 ml/kg of 60% intravenous contrast agent given as an initial bolus followed by a drip infusion. The present study duplicated this prior experiment using the 6 ml/kg dose followed by infusion in three additional unanesthetized dogs and failed to substantiate the previous findings. This discrepancy leads to the assumption that the BBB damage noted in the previous experiment was somehow related to a factor(s) other than the intravenous contrast-medium injection. The BBB cannot be disrupted in the unanesthetized dog with intravenous doses of 60% contrast media of even 6 ml/kg.
Topics: Animals; Blood-Brain Barrier; Brain; Consciousness; Diatrizoate; Diatrizoate Meglumine; Dogs; Evans Blue; Injections, Intravenous; Permeability; Staining and Labeling; Time Factors
PubMed: 6205572
DOI: No ID Found -
Pediatrics and Neonatology Aug 2014
Topics: Contrast Media; Diatrizoate Meglumine; Enema; Humans; Infant; Infant, Newborn; Intestinal Diseases; Radiography; Renal Elimination
PubMed: 24861535
DOI: 10.1016/j.pedneo.2014.04.004 -
Neuroradiology 1990A case of inadvertent intrathecal injection of diatrizoate meglumine is presented. After myelography with 10 ml i.e. 6.5 g Angiografin, a 76-year-old man rapidly...
A case of inadvertent intrathecal injection of diatrizoate meglumine is presented. After myelography with 10 ml i.e. 6.5 g Angiografin, a 76-year-old man rapidly developed myoclonus, drowsiness and excessive metabolic acidosis. He died only a few hours later. Postmortem showed non-specific brain edema. RP-HPL-Chromatography confirmed high concentration of the contrast medium in CSF (6 mg/ml) which must have induced refractory central nervous dysregulation. The lethal effects of the misapplication of this agent on the nervous system are discussed.
Topics: Aged; Diatrizoate Meglumine; Humans; Injections, Spinal; Male; Myelography; Nervous System Diseases; Spinal Osteophytosis
PubMed: 2333138
DOI: 10.1007/BF00593948 -
RoFo : Fortschritte Auf Dem Gebiete Der... Jul 1977The dose and concentration of an intra-arterially injected contrast medium, when increased approximately fivefold from a slightly hypotonic solution, produced lower...
The dose and concentration of an intra-arterially injected contrast medium, when increased approximately fivefold from a slightly hypotonic solution, produced lower tissue distribution volumes and lower extravascular diatrizoate fractions in the rat. A further fivefold increase in dose (to 1 ml/kg) with little change in concentration produced even lower early distribution volumes. Increases of concentration and dose caused a higher percentage of the contrast medium to remain within the vasculature, presumably as a result of extraction of tissue water by the hypertonic medium. Changes in the concentration of the contrast medium affected its distribution volume for a longer time than corresponding changes in the actual dose. The use of the more concentrated contrast media at higher doses should be expected to give better radiologic detail on angiograms.
Topics: Adipose Tissue; Animals; Bone Marrow; Bone and Bones; Contrast Media; Diatrizoate; Diatrizoate Meglumine; Injections, Intra-Arterial; Male; Muscles; Rats; Skin; Testis
PubMed: 142737
DOI: 10.1055/s-0029-1230658