-
European Journal of Radiology Feb 1984Immediate morphological alterations in the vascular endothelium were studied in the common iliac artery and muscle capillaries of the rat after perfusions ranging from 3...
Immediate morphological alterations in the vascular endothelium were studied in the common iliac artery and muscle capillaries of the rat after perfusions ranging from 3 to 120 seconds. Isotonic meglumine diatrizoate and saline produced no perceptible changes. Hypertonic solutions produced cell shrinkage and deformation of the intercellular spaces of the iliac artery in all cases. Shrinkage of the endothelial cells was also accompanied by shrinkage of the neighbouring cells. Hypertonic solutions did not always produce alterations in the capillaries; the frequency of such alterations was greater with saline. It is suggested that meglumine diatrizoate causes circulatory disturbance which affects its distribution to the microvasculature.
Topics: Animals; Capillaries; Diatrizoate; Diatrizoate Meglumine; Endothelium; Iliac Artery; Male; Microscopy, Electron; Muscles; Rats; Rats, Inbred Strains
PubMed: 6723670
DOI: No ID Found -
Angiology Nov 1981Ultrastructural changes in vascular endothelium after an intra-aortic injection of 65% meglumine diatrizoate, 10 ml/kg, and equiosmolal hypertonic saline were observed...
Ultrastructural changes in vascular endothelium after an intra-aortic injection of 65% meglumine diatrizoate, 10 ml/kg, and equiosmolal hypertonic saline were observed using electron microscopy in the rat. Cell shrinkage and expansion of intercellular clefts were found in all specimens from a large artery at 5 and 20 minutes after injection. Some destroyed cells were seen at all times after contrast and hypertonic saline administration, but one-half of the specimens taken at 1 hour were otherwise nearly normal in appearance. In muscle capillaries, the changes were less severe than in the large artery. Despite the large dose, equiosmolal meglumine diatrizoate and saline solutions produced identical vascular lesions as detected with electron microscopy.
Topics: Animals; Capillaries; Contrast Media; Diatrizoate; Diatrizoate Meglumine; Endothelium; Hypertonic Solutions; Iliac Artery; Male; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Sodium Chloride
PubMed: 7325408
DOI: 10.1177/000331978103201101 -
Chest Aug 1992
Review
Topics: Diatrizoate Meglumine; Female; Humans; Injections, Intravenous; Lung; Middle Aged; Pulmonary Edema; Radiography; Time Factors
PubMed: 1643957
DOI: 10.1378/chest.102.2.620 -
ANZ Journal of Surgery Nov 2022
Topics: Humans; Diatrizoate Meglumine; Intestinal Obstruction; Intestine, Small
PubMed: 36398343
DOI: 10.1111/ans.17958 -
Southern Medical Journal Dec 1992A 43-year-old man with dysphagia and a tendency to aspirate was found to have squamous cell carcinoma of the esophagus. Curative surgery was planned and preoperative... (Review)
Review
A 43-year-old man with dysphagia and a tendency to aspirate was found to have squamous cell carcinoma of the esophagus. Curative surgery was planned and preoperative computed tomography of the chest and abdomen was ordered. A ward nurse administered Gastrografin according to a "standing" order, 4 hours before the CT was to be done. The patient aspirated about 50 mL of Gastrografin, and went into cardiorespiratory arrest caused by pulmonary edema. He sustained severe brain damage and died. This is a first report of lethal aspiration of Gastrografin, given in preparation for CT. We advise alerting nurses who administer Gastrografin, especially to patients with dysphagia or impaired consciousness about the grave consequences that can result if the contrast agent is aspirated by the patient. We further advise that responsibility for using contrast agents in radiologic procedures be assumed by the radiologist and not by medical house staff.
Topics: Adult; Diatrizoate Meglumine; Humans; Male; Pneumonia, Aspiration; Tomography, X-Ray Computed
PubMed: 1470976
DOI: 10.1097/00007611-199212000-00025 -
Journal of the Canadian Association of... Mar 1978
Topics: Bupivacaine; Diatrizoate; Diatrizoate Meglumine; Drug Labeling
PubMed: 641102
DOI: No ID Found -
Clinical Otolaryngology and Allied... Dec 1982The effect of diatrizoate meglumine (Hypaque) upon the perilymphatic oxygenation has been investigated using the polarographic method in cats submitted to various...
The effect of diatrizoate meglumine (Hypaque) upon the perilymphatic oxygenation has been investigated using the polarographic method in cats submitted to various conditions such as normoxia, apnea, hypercapnia and chronically reduced vascularization. The minimal changes of the perilymphatic PO2 recorded after the injection of Hypaque permit to conclude that this drug has no practical effect upon the oxygenation of the perilymph.
Topics: Animals; Cats; Diatrizoate; Diatrizoate Meglumine; Labyrinthine Fluids; Oxygen; Partial Pressure; Perilymph
PubMed: 7160097
DOI: 10.1111/j.1365-2273.1982.tb01403.x -
Journal of Neurology Sep 1996
Review
Topics: Adolescent; Blood-Brain Barrier; Catheterization; Cerebral Ventricles; Consciousness Disorders; Contrast Media; Diatrizoate Meglumine; Female; Fistula; Humans; Paresthesia; Postoperative Complications; Posture; Scoliosis; Seizures; Subarachnoid Space; Therapeutic Irrigation; Tomography, X-Ray Computed
PubMed: 8892075
DOI: 10.1007/BF00878670 -
Australasian Radiology May 1998Allergic reactions can occur with virtually all substances used in medicine. Recently there has been increasing recognition that iodinated oral contrast agents (oral... (Review)
Review
Allergic reactions can occur with virtually all substances used in medicine. Recently there has been increasing recognition that iodinated oral contrast agents (oral contrast) used in radiology are also capable of inducing an allergic response. Fortunately these are rarely life-threatening. This paper discusses three cases of mild reactions to oral iodinated contrast (all for computed tomography (CT) scans). The Australian experience of these agents is also reviewed.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Australia; Contrast Media; Diatrizoate Meglumine; Drug Hypersensitivity; Humans; Male; Middle Aged; Tomography, X-Ray Computed
PubMed: 9599824
DOI: 10.1111/j.1440-1673.1998.tb00585.x -
Radiology Feb 1978Rats were given enemas of Gastrografin in two strengths, Renografin--76, and Tween--80 in a 10% dilution. There were no deleterious effects on the colons with these...
Rats were given enemas of Gastrografin in two strengths, Renografin--76, and Tween--80 in a 10% dilution. There were no deleterious effects on the colons with these media used in volumes to fill the colon. Severe changes resulted from volumes which produced overdistention.
Topics: Animals; Colon; Contrast Media; Diatrizoate; Diatrizoate Meglumine; Enema; Rats
PubMed: 622494
DOI: 10.1148/126.2.441