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Acta Radiologica: Diagnosis May 1977A mixture of 125I labeled meglumine diatrizoate and 131I labeled human serum albumin was injected into the femoral vein of 26 anesthetized male rats. Measurements of the...
A mixture of 125I labeled meglumine diatrizoate and 131I labeled human serum albumin was injected into the femoral vein of 26 anesthetized male rats. Measurements of the activities in cardiac blood and in different tissues of the lower extremity and in the testis were performed at time intervals ranging from 5 s to 5 min after injection. The determination of tissue uptake and distribution volumes of diatrizoate showed widely differing accumulation of contrast medium. Over 50 per cent of the intravenous bolus of diatrizoate was extravascular at 40 s.
Topics: Animals; Diatrizoate; Diatrizoate Meglumine; Femoral Vein; Injections, Intravenous; Male; Rats; Rats, Inbred Strains; Serum Albumin, Radio-Iodinated; Time Factors
PubMed: 899855
DOI: 10.1177/028418517701800304 -
Dysphagia Sep 2013
Topics: Contrast Media; Deglutition; Deglutition Disorders; Diatrizoate Meglumine; Fluoroscopy; Humans
PubMed: 23812237
DOI: 10.1007/s00455-013-9476-7 -
Extravascular distribution of intravascular meglumine diatrizoate: effect of concentration and dose.Annales de Radiologie 1978
Topics: Animals; Diatrizoate; Diatrizoate Meglumine; Injections, Intra-Arterial; Leg; Osmolar Concentration; Rats; Tissue Distribution
PubMed: 718086
DOI: No ID Found -
Canadian Association of Radiologists... Aug 1991Despite the widespread use and the assumed safety of Omnipaque (iohexol) and 3% Gastrografin (meglumine diatrizoate) as contrast media for esophagography and computed...
Despite the widespread use and the assumed safety of Omnipaque (iohexol) and 3% Gastrografin (meglumine diatrizoate) as contrast media for esophagography and computed tomography respectively, their effects on the lung if they are aspirated have never been studied. This information is important because such compounds may inadvertently enter the lungs during the diagnostic procedures. Twenty-four rats were injected intratracheally with 0.15 mL of one of three contrast agents (omnipaque, full-strength Gastrografin and 3% Gastrografin) or normal saline, which was used as a control. Radiographs were then obtained. Equal numbers from each experimental group were sacrificed after 5 minutes, 1 hour and 24 hours, and their lungs were examined pathologically. The rats injected with full-strength Gastrografin all died immediately of gross pulmonary edema. Neither Omnipaque nor 3% Gastrografin was fatal, but Omnipaque produced more edema and alveolar hemorrhage than either normal saline or 3% Gastrografin. Iohexol is, therefore, more irritating to the airways and the lung parenchyma than previously believed.
Topics: Animals; Contrast Media; Diatrizoate Meglumine; Disease Models, Animal; Extravasation of Diagnostic and Therapeutic Materials; Inhalation; Iohexol; Lung; Rats; Rats, Inbred Strains
PubMed: 1884257
DOI: No ID Found -
JAMA Jun 1977Eosinophilia, a component of the allergic response, may occur after the use of iodinated radiographic contrast media for intravenous urography. A benign transient...
Eosinophilia, a component of the allergic response, may occur after the use of iodinated radiographic contrast media for intravenous urography. A benign transient elevation in differential eosinophil count was seen in 21 of 101 patients following the injection of iodinated contrast agents for that purpose.
Topics: Diatrizoate; Diatrizoate Meglumine; Eosinophilia; Humans; Injections, Intravenous; Leukocyte Count; Urography
PubMed: 576988
DOI: No ID Found -
Archives of Disease in Childhood Nov 1986Twenty-five (37%) patients with cystic fibrosis attending our clinic have experienced acute meconium ileus equivalent. In one year 37 of 40 episodes were treated with...
Twenty-five (37%) patients with cystic fibrosis attending our clinic have experienced acute meconium ileus equivalent. In one year 37 of 40 episodes were treated with single dose oral Gastrografin with an 81% success rate, 75% being treated as outpatients. Patients found this treatment preferable to other recommended treatment.
Topics: Acute Disease; Adolescent; Adult; Child; Child, Preschool; Cystic Fibrosis; Diatrizoate Meglumine; Female; Humans; Infant; Intestinal Obstruction; Male
PubMed: 3789794
DOI: 10.1136/adc.61.11.1128 -
Journal of Pediatric Surgery Oct 2006The aim of the study was to evaluate potential benefits in the use of peroperative bowel lavage with Gastrograffin in neonates with gastroschisis.
AIMS
The aim of the study was to evaluate potential benefits in the use of peroperative bowel lavage with Gastrograffin in neonates with gastroschisis.
METHODS
A retrospective analysis of newborns with gastroschisis was performed over a 10-year period in 2 centers in the United Kingdom. Two groups were studied wherein one had peroperative bowel lavage with Gastrograffin and the other did not.
RESULTS
Data were collected on 116 patients of whom 93 were suitable for analysis. There were no statistically significant differences in primary closure rate, duration of ventilation, parenteral nutrition, or hospital stay. Intestinal obstruction occurred more frequently in the nonlavage group.
CONCLUSION
Gastrograffin lavage peroperatively in gastroschisis offers no potential advantage in reducing ventilatory requirements, parenteral nutrition, and hospital stay. It also does not achieve greater primary closure rates, but may reduce the incidence of intestinal obstruction.
Topics: Diatrizoate Meglumine; Digestive System Surgical Procedures; Female; Gastroschisis; Humans; Infant, Newborn; Intestines; Length of Stay; Male; Parenteral Nutrition; Preoperative Care; Respiration, Artificial; Retrospective Studies; Therapeutic Irrigation
PubMed: 17011269
DOI: 10.1016/j.jpedsurg.2006.05.040 -
Journal of Neuroimaging : Official... Oct 1996Life-threatening myoclonus developed in a patient following inadvertent intrathecal usage of 60% diatrizoate meglumine. Rhabdomyolysis and myoglobinuria occurred. The...
Life-threatening myoclonus developed in a patient following inadvertent intrathecal usage of 60% diatrizoate meglumine. Rhabdomyolysis and myoglobinuria occurred. The patient was successfully treated with midazolam and vecuronium and complete recovery occurred.
Topics: Aged; Contrast Media; Diatrizoate Meglumine; Humans; Hypnotics and Sedatives; Injections, Spinal; Male; Midazolam; Myoclonus; Myoglobinuria; Neuromuscular Nondepolarizing Agents; Rhabdomyolysis; Spinal Cord Diseases; Vecuronium Bromide
PubMed: 8903083
DOI: 10.1111/jon199664256 -
Fertility and Sterility 1961
Topics: Contrast Media; Diatrizoate; Diatrizoate Meglumine; Female; Humans; Hysterosalpingography; Iodipamide
PubMed: 13752164
DOI: 10.1016/s0015-0282(16)34265-0 -
Acta Radiologica (Stockholm, Sweden :... Nov 1992One hundred and eighty children undergoing CT examination were randomly allocated to receive meglumine diatrizoate, iohexol, or iopamidol as their i.v. contrast agent.... (Clinical Trial)
Clinical Trial Comparative Study Randomized Controlled Trial
One hundred and eighty children undergoing CT examination were randomly allocated to receive meglumine diatrizoate, iohexol, or iopamidol as their i.v. contrast agent. Minor side effects were detected in 85% of children receiving meglumine diatrizoate, in 18% of those receiving iohexol, and in 36% of those receiving iopamidol. Because many of these minor side effects cause patient motion or delay scanning after contrast medium injection, they potentially degrade image quality. These findings are an indication for the use of low osmolarity contrast agents for i.v. use in pediatric CT imaging.
Topics: Child; Child, Preschool; Contrast Media; Diatrizoate Meglumine; Female; Humans; Injections, Intravenous; Iohexol; Iopamidol; Male; Tomography, X-Ray Computed
PubMed: 1449887
DOI: No ID Found