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Investigative Radiology 1983To study the renal hemodynamic response to a large intravenous bolus of a radiocontrast agent, 8 ml/kg body weight of 60% diatrizoate meglumine (D-60) was infused over... (Comparative Study)
Comparative Study
To study the renal hemodynamic response to a large intravenous bolus of a radiocontrast agent, 8 ml/kg body weight of 60% diatrizoate meglumine (D-60) was infused over 30 seconds in both normal rats and rats with streptozotocin-induced diabetes. The effect of equiosmolar mannitol (1350 mOsm/kg) was compared with the D-60 response in normal rats to examine the potential role of hypertonicity in mediating a response. A similar two-phase response was seen in all three groups. The effect of D-60 in normal rats was similar to that of mannitol, but all responses were reduced in diabetic rats. During Phase I in normal rats in response to D-60 there was a transient three-minute reduction in blood pressure (BP), and renal blood flow (RBF) fell by 62 +/- 7%. During Phase II blood pressure did not change from normal baseline values, but RBF fell by 29 +/- 5%; GFR fell by 42 +/- 3%, and filtration fraction (FF) diminished. In diabetic rats baseline FF was lower than normal and was not further reduced after infusion of D-60. It is suggested that D-60 reduces RBF and GFR by a nonspecific osmotic effect, perhaps related to tubuloglomerular feedback or to an acute increase in intratubular pressure. Responses to these mechanisms may be reduced in diabetic rats with a chronic glycosuric osmotic diuresis.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Diabetes Mellitus, Experimental; Diatrizoate; Diatrizoate Meglumine; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Hemodynamics; Infusions, Parenteral; Male; Mannitol; Osmolar Concentration; Rats; Rats, Inbred Strains; Renal Circulation
PubMed: 6417044
DOI: 10.1097/00004424-198311000-00011 -
Akusherstvo I Ginekologiia 1988
Comparative Study
Topics: Diatrizoate Meglumine; Evaluation Studies as Topic; Female; Humans; Hysterosalpingography; Solutions
PubMed: 3369662
DOI: No ID Found -
West African Journal of Medicine 1992Two cases of hepato-biliary excretion of intravenous sodium and meglumine diatrizoate (Urograffin 76%) are presented. One of these patients showed specification of of...
Two cases of hepato-biliary excretion of intravenous sodium and meglumine diatrizoate (Urograffin 76%) are presented. One of these patients showed specification of of the gallbladder and colon while in the other case only the gallbladder was specified. In both cases there was marked deterioration of renal function. A brief review of the literature on hepatobiliary excretion of intravenous sodium and meglumine diatrizoate is given.
Topics: Adult; Cholecystography; Colon; Diatrizoate Meglumine; Female; Humans; Kidney Diseases; Male; Middle Aged; Urography
PubMed: 1304796
DOI: No ID Found -
Arquivos Brasileiros de Cirurgia... 2023Adhesive small bowel obstruction is one of the most common causes of surgical emergencies, representing about 15% of hospital admissions. Defining the need and timing of...
BACKGROUND
Adhesive small bowel obstruction is one of the most common causes of surgical emergencies, representing about 15% of hospital admissions. Defining the need and timing of surgical intervention still remains a challenge.
AIMS
To report the experience of using meglumine-based water-soluble contrast in a tertiary hospital in southern Brazil, comparing with the world literature.
METHODS
Patients suspected of having adhesive small bowel obstruction, according to their clinical conditions, underwent an established protocol, consisting of the administration of water-soluble contrast, followed by plain abdominal radiograph within 12 hours and by a new clinical evaluation. The protocol was initiated after starting conservative management, including fasting and placement of a nasogastric tube, as well as intravenous fluid reposition.
RESULTS
A total of 126 patients were submitted to the protocol. The water-soluble contrast test sensitivity and specificity after the first radiograph were 94.6 and 91.0%, respectively; after the second radiograph, these values were 92.3 and 100%. The general test values for sensitivity and specificity were 91.9 and 100%, respectively.
CONCLUSIONS
The measure parameters evaluated in this study were similar to those found in the literature, contributing to endorse the importance of this test in the evaluation of patients with adhesive small bowel obstruction. The particular relevance of this study was the similar results that were found using a different type of meglumine-based contrast, which is available in Brazil.
Topics: Humans; Diatrizoate Meglumine; Tissue Adhesions; Contrast Media; Intestinal Obstruction; Meglumine; Water
PubMed: 38088723
DOI: 10.1590/0102-672020230059e1777 -
Investigative Radiology Nov 1993To investigate the comparative safety profiles of nonionic and ionic contrast agents in body computed tomography (CT) studies. (Comparative Study)
Comparative Study Review
RATIONALE AND OBJECTIVES
To investigate the comparative safety profiles of nonionic and ionic contrast agents in body computed tomography (CT) studies.
METHODS
A literature search was conducted to examine the following variables: image quality, repeat or aborted studies, and the cost of nonionic agents versus benefits. Data are presented that address the following questions: Does administering nonionic agents save time? Are nonionic agents more likely to provide an adequate study? Does an adequate study necessarily ensure an improved detection rate?
RESULTS
The administration of nonionic contrast does not save time during the body CT studies. There is little significant difference between the sensitivity for making a diagnosis when using an ionic or nonionic agent.
CONCLUSION
The lack of difference in diagnostic sensitivity or time to perform a study between ionic and nonionic agents does not warrant the conversion to nonionic agents in body CT.
Topics: Contrast Media; Diatrizoate Meglumine; Humans; Iohexol; Safety; Sensitivity and Specificity; Tomography, X-Ray Computed
PubMed: 8282506
DOI: 10.1097/00004424-199311001-00021 -
Acta Radiologica: Diagnosis Jul 1977A mixture of 125I labeled meglumine diatrizoate and 131I labeled human serum albumin was injected into the lower abdominal aorta of 30 anesthetized, laparotomized male...
A mixture of 125I labeled meglumine diatrizoate and 131I labeled human serum albumin was injected into the lower abdominal aorta of 30 anesthetized, laparotomized male rats. Measurements of the activities in cardiac blood and in different tissues of the hindlimbs and tests were perfomed at six time intervals ranging from 5 seconds to 2 minutes after injection, the determine early uptake and distribution volumes of diatrizoate. Concentrations and distribution volumes were initially much greater than values obtained after intravenous injection, but these differences had considerably decreased or disappeared by 2 minutes.
Topics: Animals; Diatrizoate; Diatrizoate Meglumine; Injections, Intra-Arterial; Injections, Intravenous; Male; Rats; Serum Albumin, Radio-Iodinated; Tissue Distribution
PubMed: 920233
DOI: 10.1177/028418517701800408 -
Comparison of hepatic damage from direct injections of iodinated contrast agents and carbon dioxide.Journal of Vascular and Interventional... Oct 1999This study guides the choice of contrast agent for localization of portal veins during transjugular intrahepatic portosystemic shunt (TIPS) placement or use in... (Comparative Study)
Comparative Study
PURPOSE
This study guides the choice of contrast agent for localization of portal veins during transjugular intrahepatic portosystemic shunt (TIPS) placement or use in percutaneous transhepatic cholangiography (PTC) by providing gross anatomic and histologic comparison of effects from parenchymal injections of iodinated contrast agents and carbon dioxide.
MATERIALS AND METHODS
Eighteen New Zealand White rabbits received direct injections of 2-5 mL of either the nonionic contrast agent iohexol 300 mgI or the ionic contrast agent diatrizoate meglumine 60% into one lobe of the liver and the same volume of CO2 into the other lobe. The rabbits were killed at 2-7 days for gross and histologic evaluation of the livers.
RESULTS
At the time of injection, the diatrizoate and iohexol sites showed persistent dark discoloration, whereas CO2 sites showed minimal visible changes. On gross examination at death, all diatrizoate sites showed severe scarring and also commonly showed areas of necrosis. CO2 and iohexol sites showed only minimal discoloration and needle-puncture scars (P < .0001). The histologic grade for diatrizoate sites was significantly more severe than paired CO2 sites (P < .016). Iohexol sites showed mild histologic changes similar to paired CO2 sites (P = .375).
CONCLUSION
Iohexol and CO2 produce less severe hepatic damage and are preferred to meglumine diatrizoate for hepatic injection.
Topics: Animals; Carbon Dioxide; Cholangiography; Contrast Media; Diatrizoate Meglumine; Female; Iohexol; Liver; Male; Portasystemic Shunt, Transjugular Intrahepatic; Rabbits
PubMed: 10527206
DOI: 10.1016/s1051-0443(99)70229-0 -
Clinical Chemistry Mar 1986
Topics: Amino Acids; Diatrizoate; Diatrizoate Meglumine; Humans
PubMed: 3948406
DOI: No ID Found -
Archives of Neurology Jan 1981
Topics: Brain; Diatrizoate; Diatrizoate Meglumine; Female; Humans; Middle Aged; Multiple Sclerosis; Tomography, X-Ray Computed
PubMed: 7458731
DOI: 10.1001/archneur.1981.00510010093029 -
Emergency Radiology Apr 2007Arthrography is considered a safe procedure with rare reactions to intra-articular contrast administration. Although the use of intra-articular contrast carries a small...
Arthrography is considered a safe procedure with rare reactions to intra-articular contrast administration. Although the use of intra-articular contrast carries a small risk of reaction, no prior serious complications had been encountered in our experience with arthrography. We report a patient's prolonged reaction to contrast media after an arthrogram of the hip. Literature review demonstrated no prior report of contrast media reactions to hip arthrography. Therefore, we decided to review the literature and report our case.
Topics: Arthrography; Contrast Media; Diatrizoate Meglumine; Hip Joint; Humans; Injections, Intra-Articular; Male
PubMed: 17226017
DOI: 10.1007/s10140-006-0567-8