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European Journal of Clinical... 1983The antihypertensive effect of the peripheral vasodilator diazoxide in 13 patients and the alpha-beta adrenoceptor blocking agent labetalol in 12 patients were compared... (Clinical Trial)
Clinical Trial Comparative Study Randomized Controlled Trial
The antihypertensive effect of the peripheral vasodilator diazoxide in 13 patients and the alpha-beta adrenoceptor blocking agent labetalol in 12 patients were compared in 46 severe acute hypertensive episodes during haemodialysis. A single dose of diazoxide 150 mg or labetalol 50 mg was effective in 74% and 70% of the hypertensive episodes, respectively. In the diazoxide-treated patients blood pressure fell from 192 +/- 3/115 +/- 4 mmHg to 141 +/- 8/85 +/- 4 mmHg 2 h after injection. In 7 hypertensive episodes a second dose of diazoxide 150 mg was given 60 +/- 11 min after the first injection. The reduction in mean arterial blood pressure at the end of haemodialysis was 21.5 +/- 2.6% in patients treated with a single dose and 24.8 +/- 3.5% in patients treated with the repeated dose of diazoxide. In the labetalol-treated patients blood pressure in 17 instances fell from 198 +/- 5/104 +/- 4 mmHg to 143 +/- 7/89 +/- 5 mmHg 180 min following injection of labetalol 50 mg. In 6 episodes a second dose labetalol 50 mg was given 41 +/- 9 min after the first injection. At the end of haemodialysis the decrease in mean arterial blood pressure was 17.2% in patients treated with a single dose and 18 +/- 5% in patients given the repeated dose of labetalol. The reduction in blood pressure caused by diazoxide was slightly greater than that due to labetalol. At the end of haemodialysis the percentage reduction in mean arterial blood pressure was 23 +/- 2% in the diazoxide-treated group and 17 +/- 2% after labetalol.(ABSTRACT TRUNCATED AT 250 WORDS)
Topics: Adult; Aged; Blood Pressure; Diazoxide; Ethanolamines; Female; Humans; Hypertension; Labetalol; Male; Middle Aged; Pulse; Renal Dialysis
PubMed: 6653648
DOI: 10.1007/BF00542122 -
British Medical Journal Sep 1976
Topics: Diazoxide; Female; Humans; Hypertension, Malignant
PubMed: 963445
DOI: 10.1136/bmj.2.6035.584-a -
Archives of Disease in Childhood Jun 1968
Topics: Animals; Blood Glucose; Carbohydrate Metabolism, Inborn Errors; Child; Diazoxide; Dogs; Galactose; Glucose; Glucose Tolerance Test; Glycogen Storage Disease; Glycogen Storage Disease Type I; Hirsutism; Humans; Infant; Liver Glycogen; Male; Rats
PubMed: 5240134
DOI: 10.1136/adc.43.229.358 -
Annals of the New York Academy of... Apr 1968
Topics: Adrenal Medulla; Adult; Benzothiadiazines; Blood Glucose; Child, Preschool; Diazoxide; Epinephrine; Female; Humans; Hypoglycemia; Infant; Insulin; Male; Middle Aged; Pancreas
PubMed: 5243882
DOI: 10.1111/j.1749-6632.1968.tb19068.x -
Journal of Pharmaceutical Sciences Jul 1967
Topics: Adult; Chromatography, Thin Layer; Diazoxide; Humans; Male; Spectrophotometry; Ultraviolet Rays
PubMed: 6034840
DOI: 10.1002/jps.2600560730 -
Diabetic Medicine : a Journal of the... Nov 1991
Topics: Diazoxide; Gastrectomy; Humans; Hypoglycemia
PubMed: 1837518
DOI: 10.1111/j.1464-5491.1991.tb02130.x -
Lancet (London, England) Sep 1973
Topics: Administration, Oral; Antihypertensive Agents; Chronic Disease; Diazoxide; Drug Combinations; Drug Resistance; Humans; Hydralazine; Hyperglycemia; Hypertension; Hypoglycemic Agents; Injections, Intravenous; Kidney Failure, Chronic; Minoxidil; Vasodilator Agents
PubMed: 4125000
DOI: No ID Found -
The Journal of Pediatrics Nov 1971
Topics: Adolescent; Blood Pressure; Child; Child, Preschool; Diazoxide; Female; Glomerulonephritis; Humans; Hyperglycemia; Hypertension, Renal; Hypertrichosis; Infant; Infant, Newborn; Injections, Intravenous; Male; Nephritis; Nephrotic Syndrome; Time Factors; Uremia
PubMed: 5116710
DOI: 10.1016/s0022-3476(71)80402-x -
The Journal of Pediatrics Mar 2021
Topics: Child; Diazoxide; Humans; Hyperglycemic Hyperosmolar Nonketotic Coma; Hyperinsulinism
PubMed: 33632397
DOI: 10.1016/j.jpeds.2020.10.046 -
American Heart Journal Jun 1974
Topics: Blood Glucose; Blood Pressure; Cardiac Output; Diazoxide; Furosemide; Humans; Hypertension; Injections, Intravenous; Vasodilator Agents
PubMed: 4828816
DOI: 10.1016/0002-8703(74)90428-1