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International Journal of Molecular... Sep 2016The past decade has witnessed drugs, herbs, and dietary supplements share the common feature of potential liver injury in a few susceptible individuals.[...].
The past decade has witnessed drugs, herbs, and dietary supplements share the common feature of potential liver injury in a few susceptible individuals.[...].
Topics: Animals; Chemical and Drug Induced Liver Injury; Dietary Supplements; Humans; Plant Extracts
PubMed: 27608014
DOI: 10.3390/ijms17091488 -
The Journal of Nutrition Jun 2020Many cancer patients initiate dietary supplement use after cancer diagnosis. How dietary supplement use contributes to the total nutrient intake among cancer survivors...
BACKGROUND
Many cancer patients initiate dietary supplement use after cancer diagnosis. How dietary supplement use contributes to the total nutrient intake among cancer survivors as compared with individuals without cancer needs to be determined.
OBJECTIVES
We aimed to evaluate nutrient intakes from dietary supplements among cancer survivors in relation to their total nutrient intake and compare those with individuals without cancer.
METHODS
We evaluated the prevalence, dose, and reason for using dietary supplements among 2772 adult cancer survivors and 31,310 individuals without cancer who participated in the NHANES 2003-2016.
RESULTS
Cancer survivors reported a higher prevalence of any (70.4% vs. 51.2%) and multivitamin/mineral (48.9% vs. 36.6%) supplement use and supplement use of 11 individual vitamins and 8 minerals than individuals without cancer. Overall, cancer survivors had significantly higher amounts of nutrient intake from supplements but lower nutrient intakes from foods for the majority of the nutrients. Compared with individuals without cancer, cancer survivors had a higher percentage of individuals with inadequate intake (total nutrient intake
dietary supplements. Nearly half (46.1%) used dietary supplements on their own without consulting health care providers. CONCLUSIONS
Cancer survivors reported a higher prevalence and dose of dietary supplement use but lower amounts of nutrient intake from foods than individuals without cancer. The inadequate nutrient intake from foods and the short-term and long-term health impact of dietary supplement use, especially at high doses, need to be further evaluated among cancer survivors.
Topics: Cancer Survivors; Dietary Supplements; Dose-Response Relationship, Drug; Female; Humans; Life Style; Male; Middle Aged; United States
PubMed: 32101612
DOI: 10.1093/jn/nxaa040 -
The Journal of Nutrition Jun 2003The 1994 passage of Public Law 103-417, the Dietary Supplement and Health Education Act, resulted in an exponential increase in the number and variety of dietary... (Review)
Review
The 1994 passage of Public Law 103-417, the Dietary Supplement and Health Education Act, resulted in an exponential increase in the number and variety of dietary supplements available for over-the-counter purchase. Surveys conducted on random samples of U.S. residents have shown that approximately half of all American women use dietary supplements regularly, but very little is known about the risks and benefits of long-term and widespread supplement use. To accurately evaluate the health effects of supplement use, it is important to characterize usage patterns, motivations and costs of supplement use. However, this is a considerable challenge because accurate supplement data are difficult to collect, product databases with consistent and reliable information are lacking and survey instruments or interview protocols currently in use may not capture information about product selection for specific health conditions, motivations for use, or out-of-pocket expenditures. Future research would benefit from collaborative efforts among governmental scientists, academic scientists and industry to improve dietary supplement data collection methods and develop appropriate tools for analysis.
Topics: Dietary Supplements; Drug Costs; Female; Humans; Motivation; Nutrition Surveys; United States
PubMed: 12771352
DOI: 10.1093/jn/133.6.1992S -
Southern Medical Journal Dec 2019To assess the present use of dietary supplements among the Parkinson disease (PD) population and to determine which dietary supplements are most commonly taken.
OBJECTIVES
To assess the present use of dietary supplements among the Parkinson disease (PD) population and to determine which dietary supplements are most commonly taken.
METHODS
This cross-sectional study used an online questionnaire that was administered to individuals with PD via support group Web sites. Dietary supplement users also were asked whether they spoke with a healthcare professional about their supplement use.
RESULTS
Of the 205 respondents, 83.4% reported taking at least 1 dietary supplement. Although 94 different types of dietary supplements were identified, >50% of participants taking dietary supplements took multivitamins, vitamin D, and vitamin B (52.6%, 74.3%, and 56.1%, respectively). Respondents reported taking coenzyme Q10, , folate, vitamin B, vitamin B, melatonin, and -acetylcysteine most commonly for PD. Among supplement users, 29.2% did not discuss their supplement use with a healthcare practitioner.
CONCLUSIONS
The results of this study demonstrate a high prevalence of dietary supplement use among individuals with PD, in addition to a wide variety of supplements being taken. This study's findings also indicate the need for better dialog between patients and healthcare practitioners regarding the use of dietary supplements.
Topics: Cross-Sectional Studies; Dietary Supplements; Female; Humans; Male; Middle Aged; Parkinson Disease; Self Medication; Surveys and Questionnaires; United States; Vitamins
PubMed: 31796973
DOI: 10.14423/SMJ.0000000000001041 -
The Journal of Nutrition Jan 2023Vitamins, minerals, and natural product (NP)-derived dietary supplements are commonly used among women with breast cancer, where interactions with treatments and the...
BACKGROUND
Vitamins, minerals, and natural product (NP)-derived dietary supplements are commonly used among women with breast cancer, where interactions with treatments and the disease are possible, emphasizing the importance for health care providers to be aware of supplement use.
OBJECTIVES
The study aimed to investigate current vitamin/mineral (VM) and NP supplement use among those diagnosed with breast cancer, including usage based on tumor type or concurrent breast cancer treatments and primary information sources for specific supplements.
METHODS
Social media recruiting to complete an online questionnaire self-reporting current VM and NP use and breast cancer diagnosis and treatment information primarily attracted US participants. Analyses, including multivariate logistic regression, were performed on 1271 women who self-reported breast cancer diagnosis and completed the survey.
RESULTS
Most participants reported current VM (89.5%) and NP (67.7%) use, with 46.5% (VM) and 26.7% (NP) using at least 3 products concurrently. Top-reported (>15% prevalence) products were vitamin D, calcium, multivitamin, and vitamin C for VM and probiotics, turmeric, fish oil/omega-3 fatty acids, melatonin, and cannabis for NP. Overall, VM or NP use was higher among those with hormone receptor-positive tumors. Although overall NP use did not differ according to current breast cancer treatments, VM use was significantly less common among those currently undergoing chemotherapy or radiation, but higher with current endocrine therapy. Among current chemotherapy users, specific VM and NP supplements with possible adverse effects were still used by 23% of respondents. Medical providers were the primary information source for VM, whereas NP information sources were more varied.
CONCLUSIONS
Because women diagnosed with breast cancer commonly reported concurrent use of multiple VM and NP supplements, including those with known or underexplored risks (or benefits) in breast cancer, it is important for health care providers to inquire about and facilitate discussions regarding supplement use in this population.
Topics: Dietary Supplements; Vitamins; Minerals; Surveys and Questionnaires; Logistic Models; Neoplasms
PubMed: 36913466
DOI: 10.1016/j.tjnut.2022.12.007 -
The Primary Care Companion For CNS... 2016
Topics: Dietary Supplements; Humans; Names
PubMed: 27486550
DOI: 10.4088/PCC.16l01940a -
Food and Chemical Toxicology : An... Aug 2018Due to the extensive use of botanical dietary supplements by consumers in the United States, there is a need for appropriate research and data to support safety... (Review)
Review
Due to the extensive use of botanical dietary supplements by consumers in the United States, there is a need for appropriate research and data to support safety assessments. Complexity and variability, both natural and introduced, of botanical dietary supplements make research on these products difficult. Botanical dietary supplements are regulated by the Food and Drug Administration (FDA) under the Federal Food, Drug, and Cosmetic Act (FD&C Act), as amended by the 1994 Dietary Supplement Health and Education Act (DSHEA). They are regulated as a category of food, which differs from the regulation of pharmaceutical products. Both manufacturers and the FDA are faced with the challenge of determining the best approaches for evaluating and monitoring the safety of botanical products. High quality botanicals research requires accurate identification and characterization of the material being studied. Inconsistent results in efficacy studies of botanical dietary supplements have led to efforts to improve the rigor and reproducibility of research in the field. Addressing the challenges associated with botanical dietary supplement safety is a global effort requiring coordination between numerous stakeholders, including researchers, suppliers, manufacturers, and regulators, all of whom play a role in ensuring that high quality products are available on the market.
Topics: Dietary Supplements; Food Safety; Humans; Phytotherapy; Plant Extracts
PubMed: 29626579
DOI: 10.1016/j.fct.2018.04.007 -
MMWR. Morbidity and Mortality Weekly... Oct 2020Dietary supplement use is common among children and adolescents. During 2013-2014, approximately one third of children and adolescents (persons aged ≤19 years) in the...
Dietary supplement use is common among children and adolescents. During 2013-2014, approximately one third of children and adolescents (persons aged ≤19 years) in the United States were reported to use a dietary supplement in the past 30 days, and use varied by demographic characteristics (1,2). Dietary supplements can contribute substantially to overall nutrient intake, having the potential to both mitigate nutrient shortfalls as well as to lead to nutrient intake above recommended upper limits (3). However, because nutritional needs should generally be met through food consumption according to the 2015-2020 Dietary Guidelines for Americans, only a few dietary supplements are specifically recommended for use among children and adolescents and only under particular conditions (4). The most recently released data from the National Health and Nutrition Examination Survey (NHANES) during 2017-2018 were used to estimate the prevalence of use among U.S. children and adolescents of any dietary supplement, two or more dietary supplements, and specific dietary supplement product types. Trends were calculated for dietary supplement use from 2009-2010 to 2017-2018. During 2017-2018, 34.0% of children and adolescents used any dietary supplement in the past 30 days, with no significant change since 2009-2010. Use of two or more dietary supplements increased from 4.3% during 2009-2010 to 7.1% during 2017-2018. Multivitamin-mineral products were used by 23.8% of children and adolescents, making these the products most commonly used. Because dietary supplement use is common, surveillance of dietary supplement use, combined with nutrient intake from diet, will remain an important component of monitoring nutritional intake in children and adolescents to inform clinical practice and dietary recommendations.
Topics: Adolescent; Child; Child, Preschool; Dietary Supplements; Female; Humans; Infant; Male; Nutrition Surveys; United States; Young Adult
PubMed: 33119556
DOI: 10.15585/mmwr.mm6943a1 -
The American Journal of Nursing Dec 2022According to this study: The labeling on dietary supplements marketed to support or boost the immune system is often inaccurate and inconsistent with Food and Drug...
According to this study: The labeling on dietary supplements marketed to support or boost the immune system is often inaccurate and inconsistent with Food and Drug Administration requirements.Quality control measures appear to be insufficient for most of these products.
Topics: United States; Humans; Dietary Supplements; United States Food and Drug Administration
PubMed: 36384797
DOI: 10.1097/01.NAJ.0000904100.46205.b5 -
Journal of Nutritional Science 2022Dietary supplements can be used to compensate for an inadequate diet. However, some studies indicate that supplement users consume healthier diets than non-users,...
Dietary supplements can be used to compensate for an inadequate diet. However, some studies indicate that supplement users consume healthier diets than non-users, although such data are lacking in Japanese children. The aim of the present study was to investigate the food and nutrient intake of dietary supplement users among school-aged children in Japan. A nationwide school dietary survey was conducted at fourteen elementary schools and thirteen junior high schools in twelve prefectures in Japan. Three-day non-consecutive semi-weighed dietary records were obtained on two weekdays and one weekend day. Analysis of covariance was performed to investigate differences in food and nutrient intake from meals consumed at school and outside of school between dietary supplement users and non-users, adjusted for socio-demographic and health-related characteristics. Of the 910 children included in this analysis, 80 (8⋅8 %) reported supplement use. Based on 3-d dietary records, dietary supplement users consumed higher mean amounts of oils and lower amounts of fruits and vegetables than non-users. In school lunches, users consumed significantly higher amounts of oils and lower amounts of protein than non-users. In meals consumed outside of school, dietary supplement users consumed significantly higher amounts of confectioneries and lower amounts of fruits and vegetables, folate, vitamin C and dietary fibre than non-users. Collectively, our findings indicate that dietary supplement users consumed less healthy diets than non-users. Additional studies are warranted to confirm these results and identify factors contributing to poorer dietary habits in supplement users.
Topics: Child; Dietary Supplements; Eating; Humans; Japan; Oils; Schools; Vegetables
PubMed: 35573463
DOI: 10.1017/jns.2021.96