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Polski Merkuriusz Lekarski : Organ... May 2015Mental disorders accompanying digestive system diseases constitute interdisciplinary yet scarcely acknowledged both diagnostic and therapeutic problem. One of the mostly...
Mental disorders accompanying digestive system diseases constitute interdisciplinary yet scarcely acknowledged both diagnostic and therapeutic problem. One of the mostly recognized examples is coeliac disease where patients endure the large spectrum of psychopathological symptoms, starting with attention deficit all the way down to the intellectual disability in extreme cases. It has not been fully explained how the pathomechanism of digestive system diseases affects patient's mental health, however one of the hypothesis suggests that it is due to serotonergic or opioid neurotransmission imbalance caused by gluten and gluten metabolites effect on central nervous system. Behavioral changes can also be invoked by liver or pancreatic diseases, which causes life-threatening abnormalities within a brain. It occurs that these abnormalities reflexively exacerbate the symptoms of primary somatic disease and aggravate its course, which worsens prognosis. The dominant mental disease mentioned in this article is depression which because of its effect on a hypothalamuspituitary- adrenal axis and on an autonomic nervous system, not only aggravates the symptoms of inflammatory bowel diseases but may accelerate their onset in genetically predisposed patients. Depression is known to negatively affects patients' ability to function in a society and a quality of their lives. Moreover, as far as children are concerned, the occurrence of digestive system diseases accompanied by mental disorders, may adversely affect their further physical and psychological development, which merely results in worse school performance. All those aspects of mental disorders indicate the desirability of the psychological care for patients with recognized digestive system disease. The psychological assistance should be provided immediately after diagnosis of a primary disease and be continued throughout the whole course of treatment.
Topics: Celiac Disease; Depression; Depressive Disorder; Digestive System Diseases; Humans; Mental Disorders
PubMed: 26039016
DOI: No ID Found -
Pediatric and Developmental Pathology :... 2003Recent work is providing new insights into molecular mechanisms of digestive system development and their alteration in clinically significant disorders. An... (Review)
Review
Recent work is providing new insights into molecular mechanisms of digestive system development and their alteration in clinically significant disorders. An understanding of these mechanisms has largely been gained through the use of animal models, because many of the basic processes required in embryogenesis are functionally conserved among species. Such conserved factors include cell-cell signaling pathways and the regulation of gene expression. Disruption of these pathways have been implicated in several congenital disorders of the digestive system, including Hirschsprung disease, malrotation, altered sphincter development, Meckel diverticulum, biliary atresia, Alagille syndrome, pancreatic heterotopias, and pancreatic agenesis. In this review, we highlight recent studies in digestive system development, which elucidate mechanisms underlying congenital disorders of the human digestive system.
Topics: Digestive System; Digestive System Diseases; Embryonic and Fetal Development; Humans
PubMed: 14692642
DOI: 10.1007/s10024-002-2996-z -
Nature Reviews. Gastroenterology &... Jul 2009
Topics: Digestive System Diseases; Health Care Costs; Humans; United States
PubMed: 19575019
DOI: 10.1038/nrgastro.2009.104 -
La Revue de Medecine Interne May 1994
Topics: Adrenal Cortex Hormones; Digestive System Diseases; Humans; Risk Factors
PubMed: 8059169
DOI: 10.1016/s0248-8663(05)81451-1 -
Neuropsychopharmacologia Hungarica : a... Oct 2008
Topics: Adult; Ambulatory Care; Antipsychotic Agents; Comorbidity; Depression; Depressive Disorder, Major; Digestive System Diseases; Drug Prescriptions; Humans; Hungary; Length of Stay; Longevity; Mental Disorders; Middle Aged; Myocardial Ischemia; Neoplasms; Psychotropic Drugs; Retrospective Studies; Schizophrenia; Stroke
PubMed: 19213196
DOI: No ID Found -
Disease-a-month : DM Feb 2001
Review
Topics: Deficiency Diseases; Digestion; Digestive System Diseases; Exocrine Pancreatic Insufficiency; Gastrointestinal Hormones; Humans; Malabsorption Syndromes; Short Bowel Syndrome
PubMed: 11231382
DOI: 10.1067/mda.2000.da0470049 -
Revue Medicale de La Suisse Romande May 1989
Topics: Digestive System Diseases; Humans; Syndrome
PubMed: 2749088
DOI: No ID Found -
Gastroenterology Feb 2009
Review
Topics: Adolescent; Adult; Aged; Cost of Illness; Digestive System Diseases; Endoscopy; Female; Gastrointestinal Diseases; Health Care Costs; Humans; Male; Middle Aged; Prescriptions; United States
PubMed: 19124023
DOI: 10.1053/j.gastro.2008.12.015 -
Current Problems in Surgery Feb 2021
Topics: Biliary Tract Neoplasms; Biliary Tract Surgical Procedures; Digestive System Diseases; Humans
PubMed: 33531120
DOI: 10.1016/j.cpsurg.2020.100854 -
Fundamental & Clinical Pharmacology Jun 2019Childhood digestive disorders are a common occurrence and are sometimes unexplained. Maternal medication during the development of the foetus' digestive system may... (Observational Study)
Observational Study
Childhood digestive disorders are a common occurrence and are sometimes unexplained. Maternal medication during the development of the foetus' digestive system may contribute to the increase in childhood digestive disorders, especially with drugs acting on the cholinergic system. This study investigated the association between prenatal exposure to drugs with atropinic properties and the use of digestive disorder medications in childhood (0-3 years). Children from POMME (PrescriptiOn Médicaments Mères Enfants), a French database of reimbursed drugs for pregnant women and their children, were included (N = 8 372). Each drug prescribed during antenatal life was assigned an atropinic score (0 = null, 1 = low, 3 = strong). The prenatal atropinic burden was calculated as the sum of atropinic scores of drugs prescribed. More than 30% (N = 2 652) of the children were prenatally exposed to atropinic drugs. They used significantly more digestive disorder medications than unexposed children (RRa = 1.11 [1.06; 1.16]). The strength of the association increased with the prenatal atropinic burden. Our results suggest long-term digestive effects after prenatal exposure to atropinic drugs.
Topics: Adult; Atropine Derivatives; Child, Preschool; Cholinergic Antagonists; Cohort Studies; Databases, Factual; Female; France; Gastrointestinal Agents; Gastrointestinal Diseases; Humans; Infant; Infant, Newborn; Male; Pregnancy; Prenatal Exposure Delayed Effects; Young Adult
PubMed: 30365180
DOI: 10.1111/fcp.12428