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Nihon Rinsho. Japanese Journal of... Mar 2008Anemia is often observed in digestive diseases such as gastroduodenal ulcers, esophageal varices, atrophic gastritis, malignant neoplasms, inflammatory bowel diseases,... (Review)
Review
Anemia is often observed in digestive diseases such as gastroduodenal ulcers, esophageal varices, atrophic gastritis, malignant neoplasms, inflammatory bowel diseases, gastrectomy, malabsorption syndrome, and liver diseases. Anemia in these digestive diseases is caused by bleeding, iron deficiency, vitamin B12 deficiency including pernicious anemia, chronic inflammation (anemia of chronic disorders), malnutrition, hypersplenism. Especially in case of gastrointestinal bleeding, double balloon enteroscopy has been recently introduced to contribute to the diagnosis and treatment as well as gastroendoscopy and colonoscopy. In the treatment of digestive disease with anemia, it is important to treat digestive diseases appropriately. In treatment of patients with anemia of unknown origin, examinations about digestive diseases should be considered.
Topics: Anemia; Digestive System Diseases; Endoscopy, Digestive System; Hemorrhage; Humans; Iron Metabolism Disorders; Vitamin B 12 Deficiency
PubMed: 18326321
DOI: No ID Found -
Amyloid : the International Journal of... 2019
Topics: Aged; Amyloidosis; Digestive System Diseases; Female; Humans; Male; Middle Aged
PubMed: 31343360
DOI: 10.1080/13506129.2019.1582492 -
Gastroenterology Nursing : the Official... 2002Digestive problems in women are common and sometimes debilitating. Twenty percent of women suffer from irritable bowel syndrome, 20% have constipation, and all American... (Review)
Review
Digestive problems in women are common and sometimes debilitating. Twenty percent of women suffer from irritable bowel syndrome, 20% have constipation, and all American women will need screening for colon cancer, the number two cause of cancer death in women. This article reviews management of these disorders as well as lower gastrointestinal symptoms associated with menses, hysterectomy, fecal incontinence, and rectal bleeding.
Topics: Colonic Diseases; Colonic Diseases, Functional; Colonic Neoplasms; Constipation; Digestive System Diseases; Fecal Incontinence; Female; Gastrointestinal Hemorrhage; Humans; Rectum; United States; Women's Health
PubMed: 11852829
DOI: 10.1097/00001610-200201000-00002 -
Digestive Endoscopy : Official Journal... May 2020
Topics: Capsule Endoscopy; Digestive System Diseases; Humans; Japan
PubMed: 32124490
DOI: 10.1111/den.13659 -
Journal of Physiology and Pharmacology... Dec 2003Chronic abdominal pain is the most distressing symptom in patients with functional digestive disorders (FDD). IBS is the most common gastrointestinal disorder seen in... (Review)
Review
Chronic abdominal pain is the most distressing symptom in patients with functional digestive disorders (FDD). IBS is the most common gastrointestinal disorder seen in primary care and gastroenterology practice. IBS is a functional bowel disorder in which abdominal pain is associated with defaecation or a change in bowel habit, with features of disordered defecation and with distension. The underlying pathophysiology of IBS is unknown but a chronic visceral hyperalgesia, in the absence of detectable organic disease, is implicated. The exact location of abnormality of visceral pain processing is not known. Theories of its etiology have range widely from the original view that the disease represents a primary disturbance of gut mucosa to emerging conception of the syndrome as emanating from a complex disordered interaction between the digestive and nervous systems. Several lines of evidence suggest a strong modulatory or etiologic role of the central nervous system in the pathophysiology of IBS. A major advance in the understanding of the central mechanisms of pain processing has evolved from application of functional imaging techniques, as represented by positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). In humans, multiple components are involved in somato-visceral pain processings, including sensory-discriminative components, affective components, and cognitive components. Silverman et al, using PET, were the first to explore neural correlates of abdominal pain induced by rectal distension. If healthy subjects activated the ACC, the IBS patients did not while they presented an activation of the left PFC. These findings were consistent with an IBS model that includes both the exaggerated activation of a vigilance network (dorsolateral PFC) and a failure in pain inhibition network anterior cingulate cortex (ACC). In contrast, Mertz et al., using fMRI, observed that pain led to a greater activation of the ACC than did non-painful stimuli thus arguing for an up-regulation of afferent sensitivity to pain. Using fMRI, we also characterized cerebral loci activated by a rectal distension in healthy volunteers. The activation patterns presented a strong similarity with the central processing of somatic pain. In contrast, in a women predominant population of IBS patients, we did not observed any neuronal activation in locations activated in healthy volunteers (ACC, dorsolateral PFC) while a significant deactivation was observed in the IC and in the amygdala, a limbic structure with a role to assign emotional significance to a current experience related to anxiety and fear. Brain imaging techniques thus appear as useful tools to characterize normal and abnormal brain processing of visceral pain in patients with FDD. Reversal effects of chemical compounds targeting these abnormalities either at a peripheral or a central level should be of interest.
Topics: Animals; Brain; Digestive System Diseases; Emotions; Gastrointestinal Tract; Humans; Viscera; Visceral Afferents
PubMed: 15075447
DOI: No ID Found -
The Thoracic and Cardiovascular Surgeon Jan 2021Organ systems do not exist in a vacuum. However, in an era of increasingly specialized medicine, the focus is often on the organ system alone. Many symptoms are... (Review)
Review
Organ systems do not exist in a vacuum. However, in an era of increasingly specialized medicine, the focus is often on the organ system alone. Many symptoms are associated with differential diagnoses from upper gastrointestinal (GI) and cardiovascular medical and surgical specialties. Furthermore, a large number of rare but deadly conditions cross paths between the upper GI tract and cardiovascular system; a significant proportion of these are iatrogenic injuries from a parallel specialty. These include unusual fistulae, herniae, and embolisms that transcend specialties. This review highlights these conditions and the shared anatomy and embryology of the two organ systems.
Topics: Cardiovascular Diseases; Cardiovascular System; Digestive System; Digestive System Diseases; Humans; Iatrogenic Disease; Morphogenesis; Prognosis; Risk Assessment; Risk Factors
PubMed: 31756748
DOI: 10.1055/s-0039-1700886 -
Der Internist Apr 1999
Review
Topics: Digestive System Diseases; Forecasting; Gastroenterology; Germany; Humans; Metabolic Diseases; Research
PubMed: 10354941
DOI: 10.1007/s001080050352 -
European Journal of Gastroenterology &... Mar 2015Data on the burden of gastrointestinal diseases are incomplete, particularly in Southern European countries. The aim of this study was to estimate the burden of... (Observational Study)
Observational Study
OBJECTIVE
Data on the burden of gastrointestinal diseases are incomplete, particularly in Southern European countries. The aim of this study was to estimate the burden of digestive diseases in Portugal.
PATIENTS AND METHODS
This was a retrospective observational study based on the national hospitalizations database that identified all consecutive episodes with a first diagnosis of a digestive disease between 2000 and 2010 using ICD-9-CM codes. Comparative analyses were carried out to assess hospitalization trends of major indicators over time and across regions.
RESULTS
More than 75,000 deaths attributable to digestive diseases were observed, representing 16% of the overall in-hospital mortality. Over half of these (59%) were premature deaths (in patients <75 years of age). Biliary tract disease was the most common digestive disorder leading to hospitalization (249,817 episodes, 5210 episodes of acute stone-related cholecystitis in 2010, with an 11% increase compared with 2000). Gastric cancer was responsible for the highest number of in-hospital deaths (10,278) and alcohol-related liver disorders accounted for the highest in-hospital premature deaths (7572). Both costs and the in-hospital mortality rate for major digestive diseases showed a significant positive relation with progression of time (β=0.195, P<0.001); however, when adjusted for age, this was not significant. Significant positive associations were found between age and in-hospital mortality (odds ratio=1.032, P<0.001) and between costs and in-hospital mortality (odds ratio=1.054, P<0.001).
CONCLUSION
In Portugal, digestive diseases represent a major burden, with evidence of an increasing trend. An ageing population contributes strongly towards this increase, placing further demands on healthcare organizations. Diseases such as gastric cancer, biliary tract disease and alcohol-related liver disorders may require particular attention.
Topics: Adult; Aged; Biliary Tract Diseases; Databases, Factual; Digestive System Diseases; Female; Health Care Costs; Hospital Mortality; Hospitalization; Humans; Liver Diseases, Alcoholic; Male; Middle Aged; Portugal; Retrospective Studies; Stomach Neoplasms
PubMed: 25629572
DOI: 10.1097/MEG.0000000000000266 -
Expert Review of Gastroenterology &... Aug 2017
Review
Topics: Animals; Digestive System Diseases; Humans; Mesentery; Models, Anatomic; Models, Biological; Prognosis
PubMed: 28482706
DOI: 10.1080/17474124.2017.1329010 -
Gastroenterology Aug 2020
Topics: Digestive System Diseases; Gastrointestinal Microbiome; Humans; Probiotics
PubMed: 32531290
DOI: 10.1053/j.gastro.2020.05.058