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Journal of Nutritional Science and... 1993This paper reviewed the recent advance in the antioxidant therapy for digestive diseases. Many reports have supported that lipid peroxidation mediated by oxygen radicals... (Review)
Review
This paper reviewed the recent advance in the antioxidant therapy for digestive diseases. Many reports have supported that lipid peroxidation mediated by oxygen radicals is implicated in the pathogenesis of gastric mucosal injury, intestinal damage, acute pancreatitis, and liver injury, and several kinds of antioxidant, which are divided into the preventive antioxidant and chain-breaking antioxidant, are effective in the treatment of these diseases. A new therapeutic approach using synthesized antioxidants, such as zinc-carnosine chelate compound and ebselen, has been also proposed in these fields.
Topics: Animals; Antioxidants; Digestive System Diseases; Free Radical Scavengers; Humans; Lipid Peroxidation
PubMed: 8164065
DOI: 10.3177/jnsv.39.supplement_s35 -
World Journal of Gastroenterology Sep 2017Behavioral gastroenterology is a new interdisciplinary science that explores the influence of unhealthy lifestyles and psychological factors on the digestive system and... (Review)
Review
Behavioral gastroenterology is a new interdisciplinary science that explores the influence of unhealthy lifestyles and psychological factors on the digestive system and addresses the prevention, diagnosis, treatment, and rehabilitation of digestive diseases. Moreover, the concept of whole-course intervention with a focus on disease prevention and a new model of integrated therapy based on alterations of lifestyle and psychology are being gradually established. This paradigm may substantively impact the prevention and treatment of digestive diseases.
Topics: Diet; Diet Therapy; Digestive System Diseases; Exercise Therapy; Gastroenterology; Health Behavior; Humans; Interdisciplinary Communication; Life Style; Psychological Techniques; Risk Factors; Sedentary Behavior; Smoking; Smoking Prevention
PubMed: 28970721
DOI: 10.3748/wjg.v23.i33.6059 -
Zhongguo Fei Ai Za Zhi = Chinese... Oct 2019Immunotherapy for malignant tumors is a hot spot in current research and treatment of cancer. The activation of programmed cell death receptor-1 (PD-1) and cytotoxic T... (Review)
Review
Immunotherapy for malignant tumors is a hot spot in current research and treatment of cancer. The activation of programmed cell death receptor-1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA)-4 relevant signaling pathway can inhibit the activation of T lymphocytes. Tumor cells can achieve immune escape by activating this signaling pathway. By inhibiting this signaling pathway, immune-checkpoint inhibitors (ICIs) activate T lymphocytes to clear the tumor cells. Therefore, the adverse effects of ICIs are mainly immune-related adverse events (irAEs). The digestive system, including gastrointestinal tract and liver are vital organs of digestion and absorption, metabolism and detoxification, as well as important immune related organs, which are the commonly affected system of irAEs. This review separately explains the incidence, clinical features, diagnosis and treatment of liver and gastrointestinal adverse events in ICIs.
Topics: Animals; Digestive System Diseases; Humans; Immunotherapy
PubMed: 31650950
DOI: 10.3779/j.issn.1009-3419.2019.10.10 -
Gastroenterology Clinics of North... Sep 1998One of the most significant extraintestinal manifestations of gastrointestinal diseases is rheumatologic disorders. The gastrointestinal diseases with rheumatologic... (Review)
Review
One of the most significant extraintestinal manifestations of gastrointestinal diseases is rheumatologic disorders. The gastrointestinal diseases with rheumatologic manifestations can be divided into two major categories: intestinal disorders and disorders of the liver, biliary tree, and pancreas. The cause of diseases in each of these categories is different. Although intestinal permeability and immune responsiveness are frequently implicated in disorders of the intestine, diseases of the liver, biliary tree, and pancreas usually involve the production of autoantibodies, cytokines, or enzymes. Treatment of rheumatologic complications frequently involves therapy directed at the underlying gastrointestinal disease.
Topics: Arthritis; Autoimmune Diseases; Digestive System Diseases; Hepatitis, Viral, Human; Humans; Intestinal Diseases; Liver Diseases; Rheumatic Diseases
PubMed: 9891697
DOI: 10.1016/s0889-8553(05)70020-0 -
The Medical Clinics of North America Mar 1990Environmental factors are important mediators of many diseases of the digestive system, defined as the alimentary tract and the accessory organs of digestion, the liver... (Review)
Review
Environmental factors are important mediators of many diseases of the digestive system, defined as the alimentary tract and the accessory organs of digestion, the liver and pancreas. In this review, we principally focus on the action of chemical agents which are classified as (1) naturally occurring compounds, (2) occupational hazards, (3) therapeutic drugs, and (4) constituents of substances of abuse. In addition, the putative role of dietary habits in the pathogenesis of malignant diseases of the digestive system is discussed.
Topics: Alcohol Drinking; Chemical and Drug Induced Liver Injury; Diet; Digestive System Diseases; Digestive System Neoplasms; Environmental Exposure; Esophageal Diseases; Gastrointestinal Diseases; Humans; Liver Diseases; Mouth Diseases; Smoking
PubMed: 2181212
DOI: 10.1016/s0025-7125(16)30570-3 -
Molecular and Cellular Biochemistry Dec 2018Liver kinase B1 (LKB1, also called STK11) encodes a serine/threonine kinase mutated in Peutz-Jeghers cancer syndrome characterized by gastrointestinal polyposis....
Liver kinase B1 (LKB1, also called STK11) encodes a serine/threonine kinase mutated in Peutz-Jeghers cancer syndrome characterized by gastrointestinal polyposis. Although LKB1 plays an important role in regulating energy homeostasis, cell growth, and metabolism via activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK), nothing is known about its molecular characteristics and possible involvement in non-specific digestive disorder (NSDD) of rabbits. In the present study, we first cloned the coding sequence (CDS) of rabbit LKB1, which consisted of 1317 bp encoding 438 amino acids (AAs) and contained a highly conserved S_TKc kinase domain. Its deduced AA sequence showed 87.93-91.10% similarities with that of other species. In order to determine its involvement in NSDD, a NSDD rabbit model was built by a dietary fiber deficiency. The polymorphic site of LKB1 was then investigated in both healthy and NSDD groups using directing sequencing. Our results suggested that a synonymous variant site (840 c. G > C, CCC→CCG) existed in its S_TKc domain, which was associated with susceptibility to NSDD. Furthermore, qPCR was utilized to examine the mRNA levels of LKB1 and its downstream targets (i.e., PRKAA2, mTOR and NF-kβ) in several intestinal-related tissues from both healthy and NSDD groups. Significant changes in their expression levels between two groups indicated that impaired LKB1 signaling contributed to the intestinal abnormality in NSDD rabbits. Taken together, it could be concluded that LKB1 might be a potential candidate gene affecting the occurrence of rabbit NSDD. This information may serve as a basis for further investigations on rabbit digestive diseases.
Topics: Animals; Cloning, Molecular; Digestive System Diseases; Gene Expression Regulation, Enzymologic; Polymorphism, Genetic; Protein Serine-Threonine Kinases; Rabbits
PubMed: 29637416
DOI: 10.1007/s11010-018-3349-1 -
Endoscopy Jan 2008
Review
Topics: Biliary Tract Diseases; Biopsy, Needle; Case-Control Studies; Digestive System Diseases; Endosonography; Female; Gastrointestinal Diseases; Humans; Male; Pancreatic Neoplasms; Sensitivity and Specificity
PubMed: 18161650
DOI: 10.1055/s-2007-967023 -
Gastroenterologie Clinique Et Biologique 1997
Review
Topics: Digestive System Diseases; Humans; Polyarteritis Nodosa; Prognosis
PubMed: 9295979
DOI: No ID Found -
Intensive Care Medicine May 2003
Topics: Anti-Bacterial Agents; Cross Infection; Decontamination; Digestive System Diseases; Drug Resistance; Humans; Intensive Care Units
PubMed: 12825560
DOI: 10.1007/s00134-003-1714-2 -
Current Problems in Diagnostic Radiology 2020Congenital cystic lesions of the bile ducts represent a spectrum of liver and biliary system lesions, resulting from abnormal embryologic development of the ductal... (Review)
Review
Congenital cystic lesions of the bile ducts represent a spectrum of liver and biliary system lesions, resulting from abnormal embryologic development of the ductal plate. These disorders include Caroli disease, choledochal cysts, autosomal dominant polycystic liver disease, congenital hepatic fibrosis, and biliary hamartomas. Each disorder carries a peculiar clinical presentation, prognosis, and risk of complications. Knowledge of radiological findings of fibropolycystic liver diseases is crucial for their appropriate detection and for differential diagnosis with other similar hepatic cystic lesions, in order to avoid relevant misdiagnosis. The aim of this review is to provide an illustrative summary of the most relevant imaging findings of these conditions as encountered on ultrasound, computed tomography, and magnetic resonance imaging, and provide pearls for imaging-based differential diagnosis.
Topics: Caroli Disease; Cysts; Diagnosis, Differential; Digestive System Diseases; Genetic Diseases, Inborn; Hamartoma; Humans; Liver Cirrhosis; Liver Diseases
PubMed: 31027922
DOI: 10.1067/j.cpradiol.2019.04.005