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Medical Physics Jun 2023Beginning around 1972 with the introduction of CT, a steady transition from analog to digital imaging in radiology took place. Here, I offer a personal perspective of... (Review)
Review
Beginning around 1972 with the introduction of CT, a steady transition from analog to digital imaging in radiology took place. Here, I offer a personal perspective of the exciting multi-institutional and multidisciplinary team effort of developing digital mammography. That effort required the collaboration of visionary individuals in academic research labs, industry, and the clinical arena, catalyzed by a focused commitment from government (NCI and The Office of Women's Health). This collaboration greatly accelerated the timeline from laboratory prototypes to clinical systems and evaluation, resulting in a new imaging modality and, later, several spinoff applications (CAD, contrast-enhanced mammography, tomosynthesis) that provide improved earlier detection of breast cancer.
Topics: Female; Humans; Mammography; Breast Neoplasms
PubMed: 36709417
DOI: 10.1002/mp.16241 -
Radiology Feb 2005In digital mammography, the processes of image acquisition, display, and storage are separated, which allows optimization of each. Radiation transmitted through the... (Review)
Review
In digital mammography, the processes of image acquisition, display, and storage are separated, which allows optimization of each. Radiation transmitted through the breast is absorbed by an electronic detector, the response of which is faithful over a wide range of intensities. Once this information is recorded, it can be displayed by using computer image-processing techniques to allow arbitrary settings of image brightness and contrast, without the need for further exposure to the patient. In this article, the current state of the art in technology for digital mammography and data from clinical trials that support the use of the technology will be reviewed. In addition, several potentially useful applications that are being developed with digital mammography will be described.
Topics: Adult; Clinical Trials as Topic; Diagnosis, Computer-Assisted; Female; Humans; Image Processing, Computer-Assisted; Mammography; Radiographic Image Enhancement; Telecommunications; Tomography, X-Ray Computed
PubMed: 15670993
DOI: 10.1148/radiol.2342030897 -
Radiologic Clinics of North America May 2014Mammography is the only technology documented to reduce breast cancer mortality. Its sensitivity, however, is 75% to 80% at best and reduced to 30% to 50% in women with... (Review)
Review
Mammography is the only technology documented to reduce breast cancer mortality. Its sensitivity, however, is 75% to 80% at best and reduced to 30% to 50% in women with dense breasts. MR imaging is a sensitive modality for the detection of breast cancer but cannot be used in all patients. Its sensitivity is due in large part to its ability to detect enhancement of tumor vascularity so cancers can be detected before a mass is present. Contrast-enhanced dual-energy mammography uses the same capability of vascular enhancement and has been demonstrated to be more sensitive than routine mammography.
Topics: Biopsy; Breast Neoplasms; Contrast Media; Female; Humans; Mammography; Mass Screening; Sensitivity and Specificity; Subtraction Technique
PubMed: 24792660
DOI: 10.1016/j.rcl.2013.12.004 -
Radiologic Clinics of North America Sep 2004Despite its technical advantages, early clinical trials comparing digital mammography with film mammography for screening have been somewhat disappointing. Digital... (Review)
Review
Despite its technical advantages, early clinical trials comparing digital mammography with film mammography for screening have been somewhat disappointing. Digital mammography,however, is in its infancy and can be expected to improve more rapidly than film mammography. Some areas of improvement being observed now include the development of new detector technologies; more powerful and better-designed interpretation workstations; and novel advanced applications, such as tomosynthesis and contrast-enhanced mammography, which are not possible with standard film mammography.
Topics: Contrast Media; Female; Humans; Mammography; Radiographic Image Enhancement; Radiographic Image Interpretation, Computer-Assisted; X-Ray Film
PubMed: 15337422
DOI: 10.1016/j.rcl.2004.06.004 -
Radiologic Clinics of North America May 2017Synthesized mammography (SM) is a new imaging technique similar to digital mammography constructed from an acquired digital breast tomosynthesis (DBT) examination. SM... (Review)
Review
Synthesized mammography (SM) is a new imaging technique similar to digital mammography constructed from an acquired digital breast tomosynthesis (DBT) examination. SM allows for widespread screening using DBT, maintaining the benefits of DBT while decreasing the radiation of DBT by nearly half. This article reviews studies evaluating SM, most of which suggest that SM may be appropriate to use clinically to replace an actual acquired conventional 2-dimensional full-field digital mammogram (FFDM) when using DBT for breast cancer screening. These results should be interpreted with caution because there are inherent differences between SM and FFDM image quality and lesion visibility and larger, more robust studies still need to be performed.
Topics: Breast; Breast Neoplasms; Female; Humans; Mammography; Radiographic Image Enhancement; Radiographic Image Interpretation, Computer-Assisted
PubMed: 28411676
DOI: 10.1016/j.rcl.2016.12.005 -
AJR. American Journal of Roentgenology Nov 2020Contrast-enhanced digital mammography (CEDM) combines the high spatial resolution of mammography with the improved enhancement provided by contrast medium. In this... (Review)
Review
Contrast-enhanced digital mammography (CEDM) combines the high spatial resolution of mammography with the improved enhancement provided by contrast medium. In this article, CEDM technique-the current and potential clinical applications and current challenges-will be reviewed. CEDM is a promising technique in the supplemental evaluation of patients with mammographically inconclusive findings and potentially in the screening of women with mammographically dense breasts. CEDM is emerging as a cost-effective alternative to dynamic contrast-enhanced MRI to stage newly diagnosed breast cancer and evaluate response to neoadjuvant chemotherapy.
Topics: Breast Neoplasms; Contrast Media; Female; Humans; Mammography
PubMed: 32877247
DOI: 10.2214/AJR.19.22412 -
Journal of the National Cancer Institute Jun 2014
Topics: Breast Neoplasms; Female; Humans; Mammography; Medically Underserved Area; Sensitivity and Specificity
PubMed: 24872544
DOI: 10.1093/jnci/dju125 -
Southern Medical Journal Oct 2017Breast cancer screening with mammography reduces breast cancer mortality; however, diverging recommendations regarding screening have caused controversy. The emerging... (Review)
Review
Breast cancer screening with mammography reduces breast cancer mortality; however, diverging recommendations regarding screening have caused controversy. The emerging technology of digital breast tomosynthesis (DBT) may soon become the mainstay of breast cancer screening. We present recommendations for breast cancer screening based on guidelines. A PubMed literature review was performed and the results from five large clinical studies comparing the efficacy of digital mammography alone versus digital mammography with DBT are examined. We emphasize the importance of annual screening to reduce breast cancer mortality. Our review of the literature demonstrates that DBT increases cancer detection rates and reduces callbacks. Additional research is needed to determine whether the increased cancer detection rates are associated with a decrease in mortality.
Topics: Breast Neoplasms; Early Detection of Cancer; Female; Humans; Mammography; Practice Guidelines as Topic
PubMed: 28973699
DOI: 10.14423/SMJ.0000000000000708 -
Journal of the American College of... Sep 2005Digital mammography represents an exciting new technology for breast imaging and possibly breast screening. The decoupling of functional components in digital... (Review)
Review
Digital mammography represents an exciting new technology for breast imaging and possibly breast screening. The decoupling of functional components in digital mammography translates into potential operational efficiencies compared with screen-film mammography (SFM). Digital mammography is a platform for advanced applications not possible with traditional SFM. However, for digital mammography to replace SFM in daily clinical practice, operational and clinical hurdles will have to be overcome.
Topics: Breast Neoplasms; Cost-Benefit Analysis; Female; Humans; Mammography; Phantoms, Imaging; Radiographic Image Interpretation, Computer-Assisted; Sensitivity and Specificity; United States
PubMed: 17411924
DOI: 10.1016/j.jacr.2005.02.013 -
Clinical Obstetrics and Gynecology Dec 2016This article is an overview of the modalities available for breast cancer screening. The modalities discussed include digital mammography, digital breast tomosynthesis,... (Review)
Review
This article is an overview of the modalities available for breast cancer screening. The modalities discussed include digital mammography, digital breast tomosynthesis, breast ultrasonography, magnetic resonance imaging, and clinical breast examination. There is a review of pertinent randomized controlled trials, studies and meta-analyses which contributed to the evolution of screening guidelines. Ultimately, 5 major medical organizations formulated the current screening guidelines in the United States. The lack of consensus in these guidelines represents an ongoing controversy about the optimal timing and method for breast cancer screening in women. For mammography screening, the Breast Imaging Reporting and Data System lexicon is explained which corresponds with recommended clinical management. The presentation and discussion of the data in this article are designed to help the clinician individualize breast cancer screening for each patient.
Topics: Adult; Age Factors; Biopsy; Breast; Breast Neoplasms; Early Detection of Cancer; Female; Humans; Magnetic Resonance Imaging; Mammography; Mass Screening; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Risk; Sensitivity and Specificity; Ultrasonography, Mammary; United States
PubMed: 27741212
DOI: 10.1097/GRF.0000000000000246