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Gazette Medicale de France Jan 1960
Topics: Digitalis; Digitalis Glycosides; Glycosides; Plant Extracts
PubMed: 14431927
DOI: No ID Found -
Circulation Dec 1986The Cardiovascular Pharmacology II panel met during the AHA National Conference on Standards and Guidelines for CPR and emergency cardiac care to consider the use of... (Review)
Review
The Cardiovascular Pharmacology II panel met during the AHA National Conference on Standards and Guidelines for CPR and emergency cardiac care to consider the use of catecholamines, pressor agents, digitalis, and corticosteroids during advanced cardiac life support. During cardiac arrest, catecholamines and pressor agents have been shown to improve the rate of success of resuscitation. The useful properties of these drugs are mediated by strong alpha-adrenergic stimulation resulting in improved coronary perfusion. beta-Adrenergic stimulation during cardiac arrest is unimportant for resuscitation and potentially harmful. Studies have not demonstrated a difference between mixed agonists and alpha-agonists with respect to overall outcome. Consequently, the panel recommended that epinephrine continue to be the primary vasopressor for use during cardiac arrest. For cardiovascular support in the hemodynamically unstable patient, the panel recommended that drugs be chosen for specific pharmacologic actions that will allow the needed physiologic manipulation guided by objective hemodynamic measurements. The panel found that digitalis preparations and corticosteroids have very limited use in emergency cardiac care.
Topics: Adrenal Cortex Hormones; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Digitalis; Dogs; Humans; Plants, Medicinal; Plants, Toxic; Resuscitation
PubMed: 2877753
DOI: No ID Found -
Archivos Del Instituto de Cardiologia... Apr 1951
Topics: Blood Coagulation; Digitalis; Digitalis Glycosides; Humans; Plant Extracts
PubMed: 14858108
DOI: No ID Found -
Federation Proceedings 1946
Topics: Biological Assay; Digitalis; Digitalis Glycosides; Plant Extracts; Reference Standards
PubMed: 20981931
DOI: No ID Found -
The New Orleans Medical and Surgical... Jul 1946
Topics: Digitalis; Digitalis Glycosides; Humans; Lanatosides; Plant Extracts
PubMed: 20991535
DOI: No ID Found -
Heart (British Cardiac Society) Feb 2008In heart failure, digitalis increases exercise capacity and reduces morbidity, but has no effect on survival. This raises the suspicion that the inotropic benefits of... (Comparative Study)
Comparative Study Randomized Controlled Trial
OBJECTIVE
In heart failure, digitalis increases exercise capacity and reduces morbidity, but has no effect on survival. This raises the suspicion that the inotropic benefits of digitalis may be counteracted by serious adverse effects. Patients with atrial fibrillation (AF) were studied to clarify this.
DESIGN
In the Stroke Prevention using an ORal Thrombin Inhibitor in atrial Fibrillation (SPORTIF) III and V studies, 7329 patients with AF at moderate-to-high risk were randomised to preventive treatment of thromboembolism, either with warfarin or the oral direct thrombin inhibitor ximelagatran. The survival of users and non-users of digitalis was investigated.
RESULTS
At baseline, 53.4% of the study population used digitalis, and these patients had a higher mortality than non-users (255/3911 (6.5%) vs 141/3418 (4.1%), p<0.001; hazard ratio (HR) = 1.58 (95% CI 1.29 to 1.94)). Digitalis users also had more baseline risk factors. After multivariate risk factor adjustment, the increased mortality persisted (p<0.001; HR = 1.53 (95% CI 1.22 to 1.92 vs 1.23 to 1.92)).
CONCLUSIONS
The results suggest that digitalis, like other inotropic drugs, may increase mortality. This may be concealed in heart failure, but be revealed in patients with AF, who need the rate-reducing effect of digitalis, but do not benefit much from an increased inotropy. Cautious interpretation of the data is mandatory since the patients were not randomised with respect to digitalis use.
Topics: Aged; Anticoagulants; Atrial Fibrillation; Azetidines; Benzylamines; Cardiotonic Agents; Digitalis; Digitalis Glycosides; Double-Blind Method; Female; Humans; Kaplan-Meier Estimate; Male; Phytotherapy; Plant Preparations; Stroke; Thromboembolism; Warfarin
PubMed: 17483128
DOI: 10.1136/hrt.2006.108399 -
Klinische Medizin; Osterreichische... Mar 1949
Topics: Digitalis; Digitalis Glycosides; Plant Extracts
PubMed: 18120931
DOI: No ID Found -
Clinical Pharmacokinetics 1977
Review
Topics: Amphetamine; Antacids; Anti-Infective Agents; Anti-Inflammatory Agents; Anticoagulants; Carbenoxolone; Chlordiazepoxide; Chlorpromazine; Cimetidine; Digitalis; Drug Interactions; Ephedrine; Glucocorticoids; Humans; Levodopa; Minerals; Parasympatholytics; Pentobarbital; Pharmaceutical Preparations; Phenytoin; Plants, Medicinal; Plants, Toxic; Quinidine; Quinine; Vitamins
PubMed: 332427
DOI: 10.2165/00003088-197702040-00003 -
Journal of Food Science and Technology May 2019In this work, the nano composites of carrageenan/AgNPs/Laponite were prepared and coated on the oxygen plasma surface modified polypropylene film to enhance the barrier...
In this work, the nano composites of carrageenan/AgNPs/Laponite were prepared and coated on the oxygen plasma surface modified polypropylene film to enhance the barrier and adhesion properties. The mechanical, barrier, adhesion and antimicrobial properties were also studied to use for food packaging applications. The polypropylene film was surface modified with oxygen plasma treatment for 60 s. The AgNPs are prepared by green synthesis method from the plant. Then the carrageenan based nanocomposites were coated by roller coating method with the thickness of 24 μm. By using scanning electron microscopy, the morphology of the coating was investigated. The Laponite and AgNPs dispersion was analyzed by X-ray diffraction analysis. The tensile and adhesion strength of the coated film was increased and the OTR and WVTR were decreased after the incorporation of Laponite and AgNPs. It exhibited the strong antimicrobial activity against the and
PubMed: 31168136
DOI: 10.1007/s13197-019-03735-4 -
Revue Medicale de Liege Jul 1948
Topics: Digitalis; Digitalis Glycosides; Humans
PubMed: 18874111
DOI: No ID Found