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Recenti Progressi in Medicina Apr 2002We report an unusual digitalis poisoning case, with a positive result, caused by the swallowing of digitalis purpurea leaves. They were taken for borage leaves, usually...
We report an unusual digitalis poisoning case, with a positive result, caused by the swallowing of digitalis purpurea leaves. They were taken for borage leaves, usually used to prepare "risotto". Be careful not to eat vegetables you don't usually eat, because some of them may have different toxicity levels.
Topics: Cooking; Digitalis; Female; Foodborne Diseases; Humans; Middle Aged; Oryza
PubMed: 11989129
DOI: No ID Found -
Federation Proceedings 1947
Topics: Aminophylline; Blood Pressure; Blood Pressure Determination; Digitalis; Digitalis Glycosides; Humans; Pressure; Vasomotor System
PubMed: 20342869
DOI: No ID Found -
The Practitioner Feb 1949
Topics: Digitalis; Digitalis Glycosides
PubMed: 18108149
DOI: No ID Found -
Polski Tygodnik Lekarski Nov 1955
Topics: Acetyldigitoxins; Digitalis; Digitalis Glycosides; Plant Extracts
PubMed: 13289458
DOI: No ID Found -
The Journal of the Egyptian Medical... 1957
Topics: Biological Assay; Digitalis; Digitalis Glycosides; Plant Extracts
PubMed: 13463204
DOI: No ID Found -
Jornada Medica Dec 1949
Topics: Digitalis; Digitalis Glycosides; Plant Extracts
PubMed: 24536826
DOI: No ID Found -
Planta Jul 1998A three-step chromatographic procedure was developed for purification of cardenolide 16'-O-glucohydrolase (CGH) from Digitalis lanata Ehrh. leaves, including...
A three-step chromatographic procedure was developed for purification of cardenolide 16'-O-glucohydrolase (CGH) from Digitalis lanata Ehrh. leaves, including Phenyl-Sepharose hydrophobic interaction chromatography followed by SP-Sepharose cation exchange and Q-Sepharose anion-exchange chromatography. Starting with acetone dry powder the purification resulted in an 760-fold enrichment of CGH. Molecular weight, substrate specificity, pH optimum and temperature stability of CGH were determined. Antibodies against CGH were prepared in rabbits. The SDS gel electrophoresis of protein extracts from leaves of D. lanata and other D. species showed bands at 70 kDa and 36 kDa reacting with the antibodies. The 70-kDa protein is the main protein stained with CGH antibodies in freshly prepared extracts of D. lanata. It may represent undegraded CGH. The 36-kDa protein is enriched in aged CGH preparations. It is probably a degradation product. Proteins related to 70-kDa and 36-kDa bands also occur in crude protein preparations from leaves of D. heywoodii P. et M. Silva, D. mariana Boiss., D. purpurea L., and D. thapsi L. indicating that CGH is also present in these species. Purified CGH was digested with proteases V8 and Lys-C and the resulting fragments obtained were sequenced. One fragment had the typical amino-acid sequence of the catalytic center of family-1 glycosyl hydrolases (EC 3.2.1.x). Cardenolide 16'-O-glucohydrolase, like the other members of this enzyme family, appeared to have a glutamic acid residue directly involved in glycosidic bond cleavage as a nucleophile.
Topics: Amino Acid Sequence; Animals; Carbohydrate Sequence; Cardenolides; Digitalis; Glucosidases; Molecular Sequence Data; Molecular Weight; Plant Proteins; Plants, Medicinal; Plants, Toxic; Rabbits; Sequence Analysis
PubMed: 9640670
DOI: 10.1007/s004250050346 -
Medical Times Jun 1949
Topics: Choice Behavior; Digitalis; Digitalis Glycosides; Plant Extracts
PubMed: 18132623
DOI: No ID Found -
Journal of Vascular Surgery Feb 1987To characterize any digitalis-induced differences in intestinal blood flow autoregulation, we studied the circulatory responses of the rat intestine in control (n = 7)...
To characterize any digitalis-induced differences in intestinal blood flow autoregulation, we studied the circulatory responses of the rat intestine in control (n = 7) and chronically digitalized (n = 7) animals. Data were generated from denervated isoperfused small intestinal preparations. Arterial pressure, venous pressure, and oxygen consumption were continuously monitored. Determinations of intestinal blood flow allowed calculation of mesenteric vascular resistance and oxygen consumption. Animals underwent stepwise reductions in arterial pressure and acute venous hypertension (10 to 15 mm Hg). There were no differences in baseline hemodynamic or metabolic parameters in control (C) or digitalized (D) animals. Blood flow and oxygen consumption were autoregulated in both C and D rats until perfusion pressure decreased below 50 mm Hg. The response to acute venous hypertension was different. In D rats, venous hypertension resulted in increased vascular resistance (millimeters of mercury per milliliter per minute per 100 gm) [0.89 +/- 0.05 to 0.97 +/- 0.07; p less than 0.05], whereas C rats demonstrated no change [0.92 +/- 0.08 to 0.95 +/- 0.09]. The decrease in oxygen consumption in D rats (-14%) was slightly but significantly greater than that observed in C rats (-9%). Digitalized rats demonstrated a heightened myogenic response to acute venous hypertension with deleterious effects on vascular resistance and oxygen consumption. This reaction was intrinsic to the mesenteric circulation and not mediated by sympathetic nerves or central reflexes. Nonocclusive mesenteric ischemia in digitalized patients may reflect a similar abnormal response to the acute increases in portal pressure accompanying cardiac failure.
Topics: Animals; Blood Pressure; Digitalis; Digoxin; Homeostasis; Humans; Intestine, Small; Ischemia; Male; Mesenteric Arteries; Mesenteric Veins; Oxygen Consumption; Plants, Medicinal; Plants, Toxic; Rats; Rats, Inbred Strains; Splanchnic Circulation; Time Factors; Vascular Resistance
PubMed: 3820409
DOI: 10.1067/mva.1987.avs0050382